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Philadelphia, PA – October 4, 2012—Diabetes mellitus is a chronic disease in which individuals exhibit high levels of sugar in the blood, either due to insufficient production of insulin—the hormone that allows glucose to be absorbed by body cells—or the body’s lack of response to insulin.
In a paper published today in the SIAM Journal on Applied Mathematics, authors Mingzhan Huang, Jiaxu Li, Xinyu Song, and Hongjian Guo propose novel mathematical models for injection of insulin in type 1 and type 2 diabetes. Management of diabetes by insulin pumps usually follows an open-loop approach in which blood glucose can be periodically monitored by an individual using a glucose meter, and then adjusted by either eating a carbohydrate in cases of low blood glucose or administering a dose of insulin in cases of high blood sugar.
Research is now focused on a closed-loop approach, where a medical device will provide automatic glucose-responsive insulin administration. This type of system will greatly improve the lifestyles of diabetes patients, obviating the need for manual injections, and making diet control slightly less stringent.
In this paper, differential equation models are used to simulate injections of insulin in both open and closed-loop systems. The open loop model incorporates uniform injection of insulin at periodic intervals, where the frequency and dose of injection are chosen based on set parameters. The closed-loop model proposes injection of insulin when blood glucose level passes a certain threshold value using automatic feedback from a glucose monitoring system. The paper thus demonstrates that insulin delivery can be modeled based on both periodic (open loop) and state-dependent (closed loop) impulses. Future work involves achieving greater sensitivity by factoring specific aspects of body physiology into the artificial pancreas software, and using patient statistics to fine-tune parameters used in its algorithm.
Mingzhan Huang, Hongjian Guo and Professor Xinyu Song are researchers at the College of Mathematics and Information Science, Xinyang Normal University in Henan, China.
This work is partly supported by NIH Grant R01-DE019243, P30ES01443, and DOE Grant DE-EM0000197.
The Society for Industrial and Applied Mathematics (SIAM), headquartered in Philadelphia, Pennsylvania, is an international society of over 14,000 individual members, including applied and computational mathematicians and computer scientists, as well as other scientists and engineers.
It is a major, independent risk factor for cardiovascular disease (CVD, and the chief risk factor for stroke (accounted for about 62% of strokes). It’s often called “the silent killer” because it can be asymptomatic for many years, and people suffering of this problem can have a sudden fatal heart attack.
Elevated blood pressure levels are a common and important risk factor also for kidney failure.
Above-optimal blood pressure levels, not yet in the hypertensive range or prehypertensive, also confer excess cardiovascular disease risk, as it is shown by the fact that almost a third of blood pressure-related deaths from coronary heart disease are estimated to occur in no hypertensive individuals with systolic blood pressure levels of 120 to 139 mm Hg or diastolic blood pressure levels of 80 to 89 mm Hg (approximately 31% of the general population have blood pressure in the no hypertensive, yet above optimal blood pressure range). More than half of American adult population is included, considering hypertensive together with prehypertensive. Note: on average, blacks have higher blood pressure levels than non-blacks and an increased risk of blood pressure-related complications, particularly stroke and kidney failure.
The prevalence of the disease rises with increasing age: over half the adult population older than 60 years has hypertension. The age-related risk of high blood pressure is a function of life-style variables rather than just aging. Studies on vegetarians living in industrialized countries have shown that such dietary habits are associated with a markedly lower blood pressure levels compared with non-vegetarians; furthermore there is a lower age-related rise in blood pressure. According to a study by a team research of Johns Hopkins University (USA), prevention of hypertension begins in childhood.
A meta-analyses conducted on studies from diverse population, examining the tracking of blood pressure levels from childhood to adulthood published between January 1970 and July 2006, have shown that childhood blood pressure is associated with blood pressure in later life and elevated childhood blood pressure is likely to help predict adult hypertension (note: recent studies show that increased blood pressure levels among children is related to the growing obesity epidemic). In the last two decades a downward trend of blood pressure has been documented in the USA; the adoption of healthier lifestyle have contributed to this trend and it has given diet a prominent role Moreover, between 1980 and 2000 also the rate of death from coronary heart disease was halved and approximately half the decrease was attributable to changes in major risk factors including reductions in total cholesterol, systolic blood pressure levels (20%), smoking and physical inactivity). These changes need not be made one at a time: the best results are achieved when they are together as shown by two trials in which multicomponent interventions substantially lowered blood pressure levels in hypertensive and nonhypertensive participants. Oats, green tea, newer varieties of breakfast cereals, herbal powders and medicines are some of these that are tried and tested not just by the ones suffering the medical conditions but also by people who want to take the road to good health. One of the biggest challenges in managing diabetes type 2 – (the condition in which the body is unable to use insulin hormone to digest glucose from the sugar) is, always having to watch what we eat in order to manage the condition.
Bad: There are certain high-carbohydrate vegetables too, which need to be taken in moderation. Bad: Refined flour which processed foods such as white breads, cookies, pastries etc are rich in, should be avoided.
Good: Naturally occurring fats, such as monounsaturated fats found in almonds, avocados or polyunsaturated fats found in sunflower seeds are good for the health of the heart. Bad: Refined oils that most of the junk foods are cooked in, cheese, and butter contain saturated fats are high calorie foods which are best avoided. Good: Fresh fruits taken in moderation are good for the health as they are a rich source of dietary fiber and can also curb your craving for sugar. Bad: Stay away from canned fruits which are preserved with tons of sugar or even fruit juices that are prepared using lot of sugar and do not have the nutrients of the whole fruit. Let’s first look at what brown rice is and how it is different from the regular, more popular version of white rice. Helps to reduce weight: As brown rice is produced by merely removing the husk, the additional layers that white rice lacks, contributes to high fiber.
Cuts risk of colon cancer: Brown rice is a rich source of selenium, a trace mineral that has several benefits to the body.


Protects from free radicals: Brown rice is a rich source of manganese, yet another trace mineral, which protects cells from the effects of free radicals that are produced during energy release. Reduces the effects of cardiovascular conditions: For people, especially women in the post menopausal phase of life, consumption of brown rice often is highly beneficial, as it slows down the deposit of plaque that narrows the blood vessels. Reduces cholesterol: Brown rice contains natural oil that lowers the bad cholesterol or the LDL cholesterol.
Protection against heart disease: Brown rice consists of a phyto-nutrient known as plant lignan. Source of magnesium: Magnesium is a wonder mineral that has several positive functions in the body.
Prevents gall stones: Some studies have shown that consumption of brown rice can help avoid the development of gall stones. It is wonderful to take note that brown rice provides so many benefits and helps us lay a healthy foundation for a good life. To understand how brown rice helps manage diabetes type 2 better, it is important to understand a little bit of the digestion process.
Now, in the case of brown rice, the grain is more fibrous as it has the two outer layers of bran and germ intact. Brown rice is indeed a wonderful food for diabetics to keep their blood glucose levels under check.
As brown rice contains more fiber, it takes little bit more effort in cooking this form of rice.
It is never too late to switch to healthier forms of the foods that we are presently having. Lifestyle changes can help cure PCOS (like regular exercise, changes in diet, and weight control, blood sugar regulation, nutritional supplementation).  For more information about holistic approaches to balancing PCOS which address underlying causes and interactions between various hormones in the body, click here.
This woman is taking the drugs Metformin (which is for diabetics and can restore menstrual cycles and fertility) and Clomid (a fertility drug used to induce ovulation in women who don’t ovulate).
Type 1 diabetes occurs due to loss or dysfunction of ?-cells of the pancreas, the organ that produces insulin. The models simulate injections of insulin in the manner of insulin pumps, which deliver periodic impulses in diabetes patients.
While this is important to ensure that diabetes patients have sufficient insulin, it carries the risk of hypoglycemia, which is caused by excess insulin leading to excessive glucose absorption, resulting in low blood sugar.
Closed-loop systems achieve this by real-time feedback between glucose levels and insulin delivery, approximating the endocrine functionality of a healthy pancreas, hence, also called the artificial pancreas. The key factor here is the control algorithm, which manages insulin delivery based on glucose levels while accounting for measurement errors and kinetic delays. Algorithms are carefully designed to determine the time and dose of injections based on physiology and metabolism of insulin secretion, designed to prevent episodes of hyper and hypoglycemia. Members from 85 countries are researchers, educators, students, and practitioners in industry, government, laboratories, and academia.
Prehypertensive people have a high risk (90%) of eventually developing hypertension but this transition is not inevitable.
On the other hands, they achieve greater blood pressure reduction than non-blacks from several non-pharmacological therapies (see below). Weight gain, low physical activity, excess in salt, fats and saturated fats, cholesterol and alcohol intakes and low intakes of fresh seasonal fruit and vegetable are responsible for much of the rise in blood pressure levels seen with age. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER Clinical Trial.
True to this adage, the clutches that modern lifestyle conditions such as diabetes have over us have paved ground for the mushrooming of several health and food-related businesses. Our ancestors or even family members belonging to the older generation however did not allow these conditions to take control of their lives. There is a stark increase in the blood sugar level upon eating even a small quantity of food.
In general, it is important to watch out for foods that have a high level of carbohydrates as they are easily broken down to glucose, which is difficult for the insulin-resistant body to convert to energy. There are however different forms of this wonder grain each created through variety of processes and each differing in its effects on our health. White rice is produced by removing further two layers, the bran and the germ, leaving behind the endosperm.
Additionally, manganese also provides the body energy by helping in carbohydrate and protein digestion. It is in fact a key nutrient that our body requires to moderate the action of calcium and keeping our nerves and muscles regulated. When we consume food, the acids, enzymes and the other processes break down the food into simple elements that can be absorbed by the intestines.
It in fact comes as a surprise that rice was at one point in time consumed in its healthy whole format. Learning new varieties of recipes with such healthier alternatives makes our culinary experiments interesting. They have tried all kinds of different birth controls to try to get my hormones under control, and finally I decided to try to fix it naturally.


In addition, this approach requires diabetics to follow stringent regimens with regard to diet and insulin injections. However, development of an artificial pancreas is impeded due to lack of reliable predictive models and methods for accurate glucose monitoring, in addition to inefficient control algorithms.
The models are then qualitatively and numerically assessed by injections of insulin analogues in the environment of both type 1 and type 2 diabetes. This is helpful in cases where patients may retain some ability to secrete small amounts of insulin; excessive insulin delivery would be prevented here as signaled by low glucose levels. The Society, which also includes nearly 500 academic and corporate institutional members, serves and advances the disciplines of applied mathematics and computational science by publishing a variety of books and prestigious peer-reviewed research journals, by conducting conferences, and by hosting activity groups in various areas of mathematics. Dietary approaches to prevent and treat HTN: a scientific statement from the American Heart Association. A chat with our grandmother would help us make the revelation that there are indeed several forgotten recipes and foods that were not only a treat to our taste buds but were also full of goodness and health. While there is no cure for this condition, regular physical activity and controlled eating patterns can help in management of the condition.
It is shown that selenium inhibits proliferation of cancer cells and also repairs of DNA of damaged cells.  In addition to this selenium works together with Vitamin E and helps prevent heart disease, decreasing symptoms of asthma, and controlling the effects of rheumatoid arthritis. These lignans are found to be having functions of reducing the risk of breast, other hormone-dependent cancers and other heart diseases. This further has effects in lowering high blood pressure, reducing effects of asthma and also reducing the risk of stroke and heart attack. When white rice is consumed, it is easily broken down to the elemental form of the carbohydrate – glucose. Experts suggest that brown rice went out of fashion as it doesn’t look good or taste as good as white rice.
Some of the common recipes include brown rice salad, fried brown rice, brown rice pie and so on. Please no link dropping, no keywords or domains as names; do not spam, and do not advertise! I got pregnant with him very easily but then shortly after he was born I was diagnosed with PCOS (doctor said it is probably because of the tremendous weight gain.) I gained 45 pounds when pregnant and have had trouble with losing the weight. I have heard that the Chaste tree berry or Vitex herb helps to get rid of or lower cysts and cyst pain and helps to regulate periods!!!
The most common control for diabetes is by subcutaneous injection of insulin analogues through insulin pumps. SIAM provides many opportunities for students including regional sections and student chapters. People suffering from these conditions are willing to give almost all of these a try and end up getting disappointed when they don’t see the desired results in their health or well-being. Comfort and convenience have driven us to choose processed foods, which have short and long term effects on the body and health.
Processing of rice to enhance its taste has led to health problems taking control over our lives. Brown rice requires a little lesser amount of water than what is used for cooking white rice.
I also had a friend who didn’t have periods for two years and tried red raspberry leaf and started her period a few weeks later.
This combined with sedentary lifestyle and lack of exercise invites lifestyle conditions to become an integral part of our lives. Apart from being fibrous, the magnesium in brown rice is responsible for acting as a co-factor for over 300 enzymes.
It is indeed high time we start including this brown, nutty, chewy and more superior form of rice to our diet and take the road to good health.
A wonderful aspect about eating brown rice is that, it gives us the satiety in just small quantities.
When I started the gym about a month ago, I had about a week long period (seemingly normal but hard to tell) and now it is about time to start again but I don’t know if I should expect it or not.
By eating just a small portion, we feel full and get the satisfaction of having had a wholesome meal.
I will gladly help anyone of you get these oils, as I know the personal struggle of PCOS, weight gain, infertility, facial hair, irregular bleeding, etc.
It is heartening to see that brown rice is starting to move from the shelves of organic food stores to supermarkets, thereby increasing our access to it.
Thanks and keep your fingers crossed for me I will be taking another pregnancy test on March 17th if I don’t start a period before then.



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Comments

  1. sakira

    Change within the insulin levels or blood glucose ranges affects how.

    31.10.2014

  2. f_a_r_i_d

    The most common form ultimately her insulin spike up and then are inadequate carbs.

    31.10.2014

  3. VERSACE

    This diet is important for energy & health.

    31.10.2014

  4. ALEX

    Insulin, and if you lack enough soda, cookies, candy, and sugary.

    31.10.2014

  5. LEDI

    May also reduce the asking what kind of motorbike hypertension, without diabetes, in a randomized, controlled, three-interval, crossover.

    31.10.2014