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Leg ulcers in diabetics are the result of nerve damage and arterial blockage, which reduces sensitivity of leg dermis towards heat, pressure and injury, causing continued damage and subsequently neuropathic ulceration. The positioning of ulcers with associated clinical characterization like callus, edema or decreased pulses, will determine the predominant cause of the leg ulcer. For any lower extremity ulceration, the best treatment remains prevention of ulcer development. In active patients, compression stockings need to be used to manage the edema and treat the venous ulcer of the leg. For patients with venous ulcers and arterial occlusive disease, compression therapy can be a hazardous procedure. Diabetic patients with arterial leg ulcer should consult a vascular surgeon to determine the probability for a peripheral revascularization therapy. The arterial ulcers will only recover with sufficient tissue oxygenation that may require a need for partial amputation of the leg.
Intensive blood glucose management is must to slow the onset or progression of peripheral neuropathy for diabetic patients. Wound debridement is a process of removing nonviable tissue that if left, within the wound might lead to infection.
In case of presence of osteomyelitis along with leg ulceration, the antibiotic therapy with surgical debridement is performed, to remove the infected bone.
For diabetic leg ulcers, wound need to be kept moist and clean to prevent infection and promote granulation. Being a non-smoker is important because smoking causes blood vessels to constrict, decreasing the nutrients the nerves receive from the blood, causing further damage.
For example, if you have diabetes, you must maintain your blood glucose level within normal range through diet and the use of medications such as insulin because fluctuating glucose levels increase nerve damage. Diabetic Corneal Neuropathy is a rare medical condition that damages the eye-related nerves in the extreme cases of diabetes.
The symptoms of this chronic medical condition can go unrecognized unless it reaches its advanced stages.
As one of the first symptoms of diabetic corneal neuropathy, you can experience a decline in the peripheral vision. Headache, often considered a mild condition, people usually ignore it attributing them to different reasons like stress and lack of sleep. Unfortunately, headache can be one of the most important symptoms of diabetic corneal neuropathy. Unlike different symptoms, headaches can be the most severe during the early stages of diabetic corneal neuropathy. With the gradual decline of the eye-related nerves, people with diabetic corneal neuropathy tend to experience an increasing loss of vision. Though eyes can be strained because of a number of reasons, but if you are diabetic and suffer from constant strained eyes, then you must not ignore this condition and check with an eye specialist for it can be a symptom of diabetic corneal neuropathy. With the increase of the chronic medical condition, diabetic corneal neuropathy, you may experience blurring of the vision. Peripheral neuropathy is a debilitating disease that causes a severe impact on the quality of life of its sufferers.  Neuropathy refers to a disease of the nerves, and about one third of peripheral neuropathy cases are caused by the uncontrolled blood sugar levels of diabetes mellitus. My personal experience with tingling, burning, prickling, and numbness in the hands and fingers.

The initial symptoms are a tingling or burning sensation in the extremities, usually the feet but in a lesser percentage of people it begins in the hands or fingers.
When I went to the doctor, they were initially unsuspecting of neuropathy because of my age and relatively normal weight, plus my lack of a history with diabetes and uncontrolled blood sugar levels.  They suspected that the pain was caused by over-exertion or strain of some kind although I intuitively knew that that was not the case. It took several more weeks of persistent pain and trips to the hospital with the accompanying lab tests before it was determined that I had a blood sugar level that, while not extreme, fell in the diabetic range and was most likely causing the numbness and tingling in my hands. I knew that I desperately did not want to live with this horrible pain, but the doctors were unable to assure me that it would ever go away.  Talk about a nerve-racking diagnosis that had me worried that my quality of life would never be the same. I formed a new found dedication to proper nutrition and exercise, and was determined that if it was possible to reverse the symptoms of peripheral neuropathy in my hands, that I would do it.  I exercised almost every day and ate no sugar and only whole, unprocessed foods. I tell you this story to give you hope and a personal testament to the fact that peripheral neuropathy symptoms can in fact be healed in some cases. I urge you to heed your symptoms with the utmost seriousness and make lifestyle choices to undo the damage that has been done to your nerves.  If not, the symptoms will progress and become more painful and can lead to abscesses on the hands and fingers as well as loss of proper motor function.
Leg ulcers are the result of venous insufficiency, peripheral arterial occlusive disease or peripheral neuropathy.
Infection of a leg ulcer further increases the risk of severe damages that need to be controlled, through systemic therapy.
Edema need to be well managed with help of mechanical therapy, for treating venous insufficiency.
Compression stocking increases the healing rate of ulcers and lowers the chances of its recurrence, by reducing venous hypertension, increasing fibrinolysis and improving the microcirculation of the skin.
For those, pharmacological therapy is performed, wherein drugs of enteric coated aspirin and pentoxifylline are administered that are known to significantly reduce the leg ulceration. The therapy may involve less or more invasive vascular procedures that help to elevate the peripheral blood flow. Hence, a vascular surgeon must be consulted for arterial ulcers, to determine the right level of amputation, whenever necessary. Once ulceration initiates, treatment focuses on debridement (removal of dead or infected tissue), pressure relief and treating the core infection. Platelets get accumulated in the debrided wound, thereby promoting the inflammatory stage of wound healing. Topical growth factors, silver impregnated dressings, negative pressure wound therapy and living skin equivalents are amongst the various adjunctive therapies available at the specialist end that can be employed to treat wound, during leg ulcer care. A regular program of exercise, such as walking, is especially important because exercise maintains muscle strength and increases circulation to the legs. Whether caused by trauma (slipped or fractured disk), osteoporosis (weakening of bone) or tumors, pressure over time can cause severe and permanent nerve damage, so treatment to relieve pressure is critical. It is important to know different symptoms of diabetic corneal neuropathy to help diagnose it at its early stage and initiate a suitable treatment.
It begins to affect gradually, but when the nerves weaken due to the corneal neuropathy, it accelerates the reduction of peripheral vision. So, if you are suffering from diabetes and you experience constant headaches, it is imperative that you should not ignore and check with your doctor immediately. Early diagnosis of this critical medical condition can help start the right medication that could offer some relief to the painful headaches.

Sometimes, in its advanced stage, people may lose the vision completely and become blind forever.
In the early stages of corneal neuropathy, you may experience that your eyes are getting strained even in a short period of time. During the early stages, blurry vision may trouble you occasionally, which when ignored can lead to a constant problem.
In my personal experience with diabetic peripheral neuropathy, the symptoms first manifested themselves in my hands and not in my feet. The ABPI is calculated by dividing the systolic blood pressure in the ankle by the higher of the two systolic blood pressures in the arms.
One may also make use of multilayer of compression bandages to effectively reduce the edema.
If you have paralysis, you should have passive exercises to move your leg through a range of motion.
With some diseases, such as Guillain-Barre, you may have your blood cleansed of factors causing damage to your nerves through plasmapheresis, in which blood is removed, filtered and returned to your body.
In some cases, you may need surgical repair of a slipped disk or decompression of a nerve to relieve the pressure.
Diabetic corneal neuropathy is the decline in the functioning of nerve fibers with the rise of diabetes in the body. As soon as you observe that you are facing some difficulties with the peripheral vision, it is important that you consult your doctor without any delay, for it may be a symptom of diabetic corneal neuropathy. To avoid such a situation, it is recommended to observe the symptom for some time and check with an eye specialist along with your doctor to find an appropriate treatment. In addition, diabetic corneal neuropathy can lead to ulcers in the eyes causing blurring of the vision. If you may observe any problems with your eyes, mostly vision related, you must be alert and check with your doctor because many times diabetes can reduce the eye sight, if it is not treated on time. Obesity can add pressure on nerves, increasing nerve damage, so losing weight and establishing healthy eating habits can reduce the symptoms of neuropathy. If pressure is caused by a tumor affecting the spine, you may need surgery to remove the tumor or radiation therapy to decrease its size. An ABPI value greater than 1.3 is also considered abnormal, and suggests calcification of the walls of the arteries and noncompressible vessels, reflecting severe peripheral vascular disease. Alcohol should be avoided because it is particularly damaging to the nervous system, both directly and because of associated vitamin deficiencies. If you have nerve compression originating lower in your leg, such as from a knee or ankle injury, sometimes braces or orthopedic supports can reduce nerve pressure and relieve symptoms.
Chronic pain often does not respond well to conventional pain medications, but pain control, which may include anti-epileptic drugs, tricyclic antidepressants and local anesthetics, is very important to allow you to carry out lifestyle changes.

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