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Intarcia Therapeutics and French pharmaceutical research company Servier have established a $1 billion strategic partnership for the development of ITCA 650 outside the United States and Japan. The two companies will now join forces to enhance the development of the therapeutic, which is administered through a small, matchstick sized mini-pump placed sub-dermally, making it a major advancement in the treatment of type 2 diabetes if it successfully passes the remaining phase 3 trials. The partnership agreement stipulates that Intarcia will receive more than $1 billion in an upfront payment, regulatory and sales milestone payments, and tiered sales-related payments from worldwide revenues, excluding the U.S. The phase 3 clinical trial program for the technology, called FREEDOM, is expected to result in the filing of global submissions in the first half of 2016, and will continue to be conducted by Intarcia. The purpose of the investigational therapy is to offer continuous and consistent drug treatment through the ongoing subcutaneous delivery of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist currently recommended globally for diabetes in the form of self-injection twice a day or once a week, depending on the prescription. Intarcia has recently presented the primary endpoint of two of its four phase 3 trials to assess the medication, which have revealed positive outcomes. Leonor is an emerging, young journalist who writes daily for BioNews Texas, covering business, science, and health news.
Boehringer Ingelheim’s and Eli Lilly and Company’s joint product, Synjardy (empagliflozin and metformin hydrochloride,) has received U.S. It is generally assumed, in health-related research, that males and females of a given species respond to a specific drug in much the same way. Disclaimer:Diabetes News Journal is strictly a news and information website about the disease. A big credit to rising life expectancy trends goes to pharmaceutical companies for improved treatments options to many of these diseases and disorders. Harris, on behalf of the MetLife Foundation, conducted its survey in September 2010 by asking 1,007 U.S. Diabetes is often brushed aside as a nuisance rather than a serious disease, but prolonged exposure to high blood sugar can cause heart attack, stroke, and kidney failure. Just last week, actor Tom Hanks admitted that he has been dealing with symptoms of type 2 diabetes for the past two decades. To put heart disease's mortality into scope, the fourth through 10th leading causes of death in 2010 don't combine to account for the number of deaths caused by heart disease.
An exciting new treatment to watch here would be Pfizer and Merck's Liptruzet, which is targeted as an LDL-cholesterol lowering drug (the bad type of cholesterol).
Perhaps the biggest reason Alzheimer's jumps up the list is because it's one of the most misunderstood and relatively untreatable diseases still out there. The disease itself is incredibly tricky to treat because of the blood-brain barrier, which makes getting medication from the blood into the brain difficult. When it comes to treating Alzheimer's, I would suggest keeping your eye on Eli Lilly despite its late-stage disappointment with solanezumab. Two more cancer-focused biotechs that could change the gameThe best way to play the biotech space is to find companies that shun the status quo and instead discover revolutionary, groundbreaking technologies.
Fool contributor Sean Williams has no material interest in any companies mentioned in this article. Intensive lifestyle intervention prevented T2DM in participants, independent of the level of genetic burden. Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, 50 Staniford Street, 9th floor, Boston, MA 02114, USA. Section of General Internal Medicine, VA Boston Healthcare System, Harvard Medical School, 50 Staniford Street, 9th floor, Boston, MA 02114, USA.
General Medicine Division, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, 9th floor, Boston, MA 02114, USA.
All authors researched the data for the article and provided a substantial contribution to discussions of the content. Marie-France HivertMarie-France Hivert, MD, MMSc, is an Assistant Professor and faculty member in the Department of Population Medicine at Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, USA. The UK is seeing an explosion of diabetes linked to growing obesity rates, experts are warning.
And by 2005, more than 4% of the population was classed as having diabetes - nearly double the rate of 10 years earlier.
The bulk of cases are type 2 diabetes -which is linked to being overweight or obese - the Journal of Epidemiology and Community Health reports. The findings suggest that rates of diabetes are increasing at a faster rate in the UK than they are in the US, where prevalence of the disease is already one of the highest in the world.
Of more than 42,642 people who were newly diagnosed with the disease between 1996 and 2005, just over 1,250 had the "insulin-dependent" type 1 diabetes, and more than 41,000 had later-onset type 2 disease, which is linked to lifestyle. While the numbers of new cases of type 1 diabetes remained fairly constant over the decade, the numbers of new cases of type 2 diabetes did not. The researchers from Spain and Sweden who analysed the data from almost five million medical records say the trends are not due to increased screening or the UK's ageing population, but from rising obesity rates. Over the course of the study, the proportion of patients newly diagnosed with type 2 diabetes who were obese increased by a fifth. Douglas Smallwood, chief executive of Diabetes UK, said: "This research is a sad indictment of the current state of the UK's health. Professor Alan Maryon-Davis, president of the UK Faculty of Public Health, said: "Early detection and treatment are crucial. There are currently over 2.5 million people with diabetes in the UK and there are more than half a million people with diabetes who have the condition and don't know it.


Type 2 diabetes usually appears in people over the age of 40, however, recently, more children are being diagnosed with the condition, some as young as seven. According to Diabetes UK, statistics show that over 80% of people diagnosed with type 2 diabetes are overweight. The NHS is spending ?1m an hour - 10% of its yearly budget - treating diabetes and its complications, according to the charity. A Department of Health spokesperson said the rise in recorded diabetes cases was partly due to improvements in diagnosis, along with rising rates of obesity and an ageing population.
As a result, more people were getting the support, advice and treatment required to prevent or delay complications. For carrying out section 301 and title IV of the PHS Act with respect to arthritis and musculoskeletal and skin diseases, [$520,053,000] $520,189,000. NIAMS will support 299 pre- and postdoctoral trainees in full-time training positions, a flat level from the number funded in FY 2014. Authorizing Legislation: Section 301 and title IV of the Public Health Service Act, as amended.
As the primary Federal agency for supporting medical research on diseases of the bones, joints, muscles, and skin, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) touches the lives of nearly every American. Over the years, NIAMS-supported research teams have made significant progress in uncovering the causes of and improving the treatments for many disorders of the bones, joints, muscles, and skin.
As researchers learn more about the cellular pathways that control development, growth, and repair, they are discovering many shared processes among the cells of the bones, joints, muscles, and skin. Recent musculoskeletal research advances also have contributed to the recognition that bone, cartilage, connective tissue, and muscle communicate with one another through signaling molecules in health and disease.
Over the past decade, the genome-wide association approach to identify genetic regions related to disease risk has matured from an intriguing concept to a widely used scientific tool. Many of the genetic variants identified in genome-wide association studies occur in segments of DNA that were previously considered to be of little importance because they do not code for functional proteins.
The NIH recently launched the Accelerating Medicines Partnership (AMP), which is a collaboration between the NIH, the Foundation for the National Institutes of Health, 10 pharmaceutical companies, and several health advocacy organizations. NIAMS also supports clinical studies that help patients and their healthcare providers make better-informed decisions.
NIAMS is committed to ensuring that a sufficient number of well-trained basic scientists and clinical researchers are prepared to conduct cutting-edge studies related to musculoskeletal, skin, and rheumatic diseases.
NIAMS is also supporting opportunities for interdisciplinary research to help inform and address Institute mission areas.
Arthritis and Rheumatic Diseases: This program advances high-quality basic, translational, and clinical biomedical and biopsychosocial research to treat, cure, and prevent arthritis and other rheumatic diseases. The drug is Intarcia’s phase 3 investigational therapy for the treatment of type 2 diabetes, and is expected to become the first injection-free GLP-1 agonist in the world, to be administrated only once or twice a year.
ITCA 650 can be inserted into a patient by a qualified physician, nurse, or physician’s assistant in a simple, fast procedure. The company believes that, in addition to the reduction of medication regularity, using the osmotic pump may improve the treatment by maintaining therapeutic protein and peptide stability at normal body temperatures for a sustained period of time. She holds a bachelor’s degree in Communication and post-graduate degree in Multiplatform Journalism. Food and Drug Administration (FDA) approved Adlyxin (lixisenatide) as a new treatment for type 2 diabetes this week. According to the World Health Organization's International Classification of Disease, version 10, there are 12,420 different types of diseases in the world.
Certain diagnoses have a way of inspiring fear in Americans unlike others, which is why, in 2011, Harris Interactive set out to discover exactly what those were. Rather, they develop diabetes through some mixture of genetics and lifestyle habits such as poor food choices or lack of physical exercise (type 2 diabetes). It's my personal hope that having a high-profile role model in place will give this disease the acclaim it needs to get high-risk people to eat healthier and exercise more. The reason SGLT2 inhibitors are so exciting is that they work in the kidneys to block glucose absorption, as opposed to previous generations of diabetes drugs that worked out of the pancreas and kidneys. 4: Stroke (8%) Stroke was the fourth-leading cause of death in 2010, but you'd hardly know it with just 8% of Americans saying they fear it the most. Other factors that increased your chance of a stroke included hereditary factors like ethnicity and age, as well as existing medical conditions like high blood pressure, high cholesterol, and of course, diabetes. This revolutionary blood thinner was approved by the Food and Drug Administration in late December to prevent stroke in patients with atrial fibrillation. Liptruzet -- which is an oral medication comprised of Pfizer's generic Lipitor and Merck's cholesterol absorption inhibitor Zetia -- demonstrated an LDL reduction of 53%-61% in trials compared to just 37%-54% for Lipitor alone and 20% for Zetia as a monotherapy.
2: Alzheimer's disease (31%) Please note the monstrously large jump between heart disease at No.
Harris Interactive's poll notes that 62% of those polled admitted to knowing "nothing" or only "very little" about Alzheimer's. In 2012, international scientists chose solanezumab -- which attaches to amyloid floating free in the brain before it attaches and become plague -- and LY2886721 -- which blocks a specific enzyme used to make amyloid -- (as well as a drug from Roche) for a long-term (three-year) Alzheimer's study out of 15 possible drugs.
2 leading cause of death behind heart disease likely tops the rankings because of how quickly the disease can strike and the suffering it can cause. This experimental therapy has received the breakthrough therapy designation from the FDA and was recently submitted as a new drug applicant based on some incredible mid-stage study results.


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The graph shows the T2DM incidence rate in each arm of the study by quartile of a 34-locus GRS. She is an endocrinologist and clinical scientist with expertise in physiology and the genetic epidemiology of type 2 diabetes mellitus, prediabetes (including gestational diabetes mellitus) and glycaemic traits.
Sadly, the statistics are not surprising as we know that the soaring rates of type 2 diabetes, are strongly linked to the country's expanding waistline.
AMP investigators will identify and validate promising biological pathways and targets in three disease areas, including Alzheimer’s disease, diabetes, and the autoimmune disorders, rheumatoid arthritis and lupus. Department of Health and Human Services, Agency for Healthcare Research and Quality, Medical Expenditures Panel Survey, 1996 – 2006. Both of the companies will contribute to future global investments associated with the development of the life cycle management of the ITCA 650, which includes new head-to-head superiority research to evaluate it against leading diabetes medications and planned novel combination regimens.
Servier will be in charge of seeking regulatory approvals in other countries, as the company believes that “this disruptive injection-free GLP1 could reshape the treatment of type 2 diabetes in the very near future and corresponds to our objectives for patient care in metabolic diseases,” according to Isabelle Tupinon-Mathieu, head of the Metabolism Innovative Center at Servier. She is particularly interested in politics and current affairs, and is currently studying for a masters degree in economics and public policies.
This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Approximately 90% of the aforementioned diabetes cases in this country are of the type 2 designation. This relatively low percentage could have a lot to do with the risk factors for stroke being pretty well-defined. This doesn't make the prospect of having a stroke less scary, but it does help narrow down a person's risk potential dramatically. When pitted side-by-side against Warfarin, which has been a blood-thinning mainstay for two decades, it outperformed in numerous categories. With a whopping 35.7% of this country considered obese -- and obesity coming with a higher risk of high blood pressure, high cholesterol, and diabetes -- the deck is stacked against a good percentage of the population. Furthermore, Liptruzet also boosted the production of HDL cholesterol, the good type of cholesterol. Furthermore, the poll indicates that even though 44% of respondents noted knowing a family member or friend with Alzheimer’s, only 18% of people have developed a plan should they get Alzheimer's, with regard to long-term care options and financial planning. It's far too early to guess whether these compounds will be successful, but you have to like Eli Lilly’s chances with two of its experimental drugs being chosen out of 15 hopefuls. This isn't to say that the aforementioned diseases aren't debilitating, but treatment for many cancer types can involve painful surgeries, radiation and chemotherapy that can lead to unpleasant side effects, and very low success and survival rates depending on the cancer type.
Ibrutinib is designed to treat mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), the most common form of leukemia in adults.
We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The results suggest that individuals at high genetic risk of T2DM benefit from intensive lifestyle intervention as much (or even more) than individuals at low genetic risk. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
In addition, previous type 2 diabetes medications either caused weight gain or were weight neutral as in the case of DPP-4 inhibitors, but Invokana was actually shown to induce weight loss in patients!
It's hard not to be concerned with heart disease because there are so many variables that act as risk factors, including high blood pressure, high cholesterol, obesity, diabetes, poor diet, your gender, and family history.
Some of the more common cancer types like lung cancer and pancreatic cancer carry with them five-year survival rates of just 17% and 6%, respectively.
In MCL trials, ibrutinib delivered an overall response rate (ORR) of 68% with a median response duration of 17.5 months while offering an ORR of 71% in treating CLL. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
I'll also add some investing flair by noting an existing or upcoming drug worth keeping an eye on within each disease type that could have an opportunity to significantly change things for the better. Vassy, MD, MPH, SM, is an Instructor in Medicine at Harvard Medical School and a clinician-investigator in the Section of General Internal Medicine of the VA Boston Healthcare System and in the Division of General Medicine and Primary Care at Brigham and Women's Hospital, all in Boston, MA, USA. MPH, is Associate Professor of Medicine at Harvard Medical School and the General Medicine Division, Department of Medicine at Massachusetts General Hospital, Boston, MA, USA. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. His group studies the causes and prevention of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), using the biochemical and genetic epidemiology of insulin resistance, T2DM and CVD. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.



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