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High blood glucose (hyperglycemia) eventually damages critical organs and systems like the liver, kidneys, nerves, circulatory system, and the reproductive system.
Diabetes Care, a monthly online magazine published by the American Diabetes Association, reported the results of a study on the global incidence of diabetes in people over the age of 20. There are several risk factors like age, ethnicity, family history, and weight, which increase a person’s chances of developing type 2 diabetes. In 1997, five time Olympic gold medalist and world rowing champion Sir Steve Redgrave discovered he had type 2 diabetes. Due to its inability to metabolize glucose properly, the body turns to other energy sources like fat stores and muscles. Due to hyperglycemia, fluid is drawn out from the lens of the eyes, which impairs a diabetic’s ability to focus.
Another symptom of type 2 diabetes is the formation of dark patches in areas like the neck and armpits. Although there are many symptoms of type 2 diabetes, they are usually inconspicuous in the initial stages. This gradual progression makes symptoms less noticeable as people slowly get used to them over time and don’t realize anything is wrong.
As the condition can often remain hidden, it is also important to periodically check for diabetes.
If you hit your thumb with a hammer, the resulting swelling and inflammation is obvious, painful, and short lived.
Inflammation is the life-saving component of your immune system that helps fend off bacteria, viruses, fungi, and other microbial invaders. Medical schools don’t teach much about the inflammatory effects of food, toxic chemicals, orEMF so the medical profession has been slow to appreciate the extent of the problem. Their work has stimulated research into microbes as possible reasons for other chronic inflammatory conditions, such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis and atherosclerosis, the Nobel assembly said in its citation.
Chronic inflammation has a damaging effect on arteries, which can lead to high cholesterol, heart attacks and strokes. Chronic inflammation depresses the immune system and helps promote the formation of cancerous tumors. Consider what our great-grandmother had to eat; she lived in a time when chronic inflammation and chronic diseases were not rampant. Transition away from inflammatory foods like sugar, refined carbs (pasta, chips, crackers, cookies), and store-bought milk. Deregulation of epigenetic profiles has been described in several human pathologies, including complex diseases (such as cancer, cardiovascular and neurological diseases), metabolic pathologies (type 2 diabetes and obesity) and imprinting disorders.
However, in recent years we have accumulated some evidence about the role of germline mutations of epigenetic modifiers and their contribution to the development of human diseases.
Evidence is mounting of the involvement of genetic mutations of genes related to DNA methylation, such as Rett syndrome (due to mutations in the methyl-binding domain protein MeCP2) and Immunodeficiency Centromeric instability Facial syndrome 1 (ICF1) (due to mutations in the DNA methyltransferase DNMT3). Until now, we had identified genetic mutations that could change the epigenetic patterns; but we still do not understand which are the altered putative downstream genes (epigenetically regulated) that result in specific clinical phenotypes.
New Delhi: According to Defence Ministry official, an Indian Air Force aircraft AN-32 went missing today with 29 people on board. An IAF official said that the aircraft was “courier flight with service personnel on board. The IAF along with Indian Navy has started major hunt and rescue operation of the aircraft in the Bay of Bengal.
The Indian Navy official has said that they have rolled out one P-8I surveillance aircraft, one Dornier and four ships have been deployed in the search and rescue operation.
Overweight or obese people are at a substantially higher risk for high blood pressure, high cholesterol, type 2 diabetes, heart disease, stroke, gallbladder disease, arthritis, problems breathing, sleep apnea, and certain cancers.
It secretes inflammatory adipokines such as interleukin (IL)-6, macrophage chemoattractant protein-1 (MCP-1), and resistin. Having excess visceral fat greatly increases one's chance of having diabetes and heart disease. Visceral Fat causes impairments in blood sugar metabolism and causes insulin resistance, which can lead to Type 2 Diabetes. Visceral Fat is broken down by the liver to create low-density lipoproteins (LDL), which circulates throughout the blood stream. There is a direct correlation between a person's waist circumference and their chance of having diabetes and heart disease. A Waist Circumference of 32 inches for a woman and 37 inches for a man indicates a significantly raised risk of developing heart disease or diabetes.
Visceral Fat is consumed more quickly by the body than subcutaneous fat when undergoing regular exercise due to the fact that it is more metabolically active. In 1995, the total costs attributable to obesity in the nation, both in losses of productivity and in medical expense, are estimated to be $99 billion.


It is a serious condition that cripples the body’s ability to process glucose, its primary energy source. The problem is easily detected and treated, but many people suffering from it are unaware of their condition.
These days, due to sedentary lifestyles, overeating, and excess weight, even children and teenagers are not immune to it, and the condition is increasingly common in people in their late twenties.
This can be due to insufficient insulin production, the body’s inability to make use of the available insulin (insulin resistance), or a combination of both.
Their body either goes through a starvation mode due to very low blood glucose levels or excess glucose creates complications. In fact, people with diabetes have twice the normal risk of getting a heart attack or stroke. A study published in the journal of the American Medical Association concludes the chances of developing the disease increases with age, and a large percentage of the population will eventually develop the condition.
It is now a well-known fact that obesity and lack of exercise are the chief lifestyle related factors that put young people at risk.
He was just 35 and other than a family history of the condition, he had no other risk factors. This can be due to low blood glucose levels or the inability of the body to move glucose into the cells due to a lack of insulin. Despite eating frequently and without any extra physical activity, many diabetics experience unexplained weight loss. If you experience one or more of the above symptoms, see your doctor or get a blood test done without delay. If you’re currently in the prediabetic stage or if your condition is mild to moderate, simple lifestyle and dietary changes like those outlined in Diabetes Destroyer and the Defeating Diabetes Kit may be sufficient to control and even reverse it.
Your immune system sends white blood cells and other hormone-like substances to help start the healing process. Without inflammation we would be sitting ducks in a very hostile world, with no way to repair the damage constantly inflicted on us.
The stimulus might come from an army of free radicals launched every day when we eat foods made with processed vegetable oils – French fries, fried food, non-fat dried milk, powdered coffee creamer, most salad dressings, crackers, cookies, chips, and a plethora of other processed and convenience foods. Now you can see why suppressing cholesterol production is not a good way to address the problem.
A substantial body of evidence supports the conclusion that chronic inflammation can predispose an individual to cancer as demonstrated by the association between chronic inflammatory bowel diseases and the increased risk of colon carcinoma. The inflammation in a joint can eat away at cartilage and you’ve got a serious case of arthritis. One anti-inflammatory compound in food that has been studied extensively is curcumin, the yellow pigment in the curry spice turmeric.
If you snack on wild blueberries and goji berries, you are snacking on foods high in antioxidants. Commercial dairy cows are fed an unnatural diet of grain that produces excessive omega-6 fats.
In the 1940′s, researchers thought they found a strong correlation between cancer and the consumption of fat, and fat became demonized. Deleterious epigenetic profiles could be a consequence of mutations in the “writers” “erasers” and  “readers”, that is to say, dysfunctional enzymes that are responsible for putting in and out the epigenetic marks and for their cellular interpretation. Most of these disorders are included under the term “rare diseases” – any disease that affects a small percentage of the population (although there is no general consensus about what “small percentage” exactly means). In contrast to the limited number of mutations affecting DNA methylation, the huge number of rare disorders that could be associated with mutations in histone modifiers and chromatin-remodelling proteins must be highlighted. Most importantly, we are still in the infancy of the understanding of how such epigenetic defects (potentially reversible) could provide a target for therapeutic intervention. Among the 29 people on board there were six crew members in the aircraft which went missing today. It produces many chemicals and hormones, both good and bad, which are circulated through the bloodstream. It produces more harmful hormones and enzymes such as interleukin(IL)-6, and suppresses positive ones such as leptin. A Waist circumference of 35 inches for a woman and 40 inches for a man is considered high risk for developing both conditions. This is unfortunate because with timely detection and proper treatment, serious complications can be avoided. However, having the ideal BMI or a physically active lifestyle is no guarantee against the condition.
Increased urination requires more water, and this is obtained by drawing water from the tissues.
Diabetes also makes people more prone to fungal infections, especially in the genital areas.


An estimated 80 percent of visits to doctor’s offices are for issues relating to chronic disease. Robin Warren turned medical dogma on its head by proving that bacteria – not stress – caused ulcers. Recently, we are hearing that statins’ best asset may be their anti-inflammatory properties. In Rheumatoid Arthritis, the inflammation is systemic, eating away at the entire body, an autoimmune disorder.
If arthritis runs in your family, then you very possibly have a genetic weak link in that regard and you are likely prone to arthritis. Greg Cole, professor of medicine and neurology at UCLA, has found that small doses reduce TNF-alpha and IL-1.
Wheat today is also high in glutamine, an amino acid that has an inflammatory effect on the body. If you are allergic to dairy, as many are, that allergic reaction feeds chronic inflammation. Supermarket beef generally comes from cattle fed an unnatural diet of grain, meaning unwanted residues of hormones, steroids, antibiotics – and meat that is acid. They provide the building blocks for cell membranes and a variety of hormones and hormone-like substances which we need. Dozens of studies have shown that the omega-3s can help prevent heart attacks and sudden cardiac death by preventing arrhythmias, making blood less likely to clot in arteries, improving the balance of good and bad cholesterol and limiting inflammation. As the most studied example, more than 40 de novo recurrent disruptions of several genes encoding components of the epigenetic machineries are typically observed in many tumors [1]. Homozygous mutations affecting epigenetic enzymes are lethal reflecting the vital role of epigenetics in normal development and differentiation. Why this frequency?  There is not clear explanation; however, it could be associated with the overlapping function of histone modifiers in specific residues. The possibilities have only just begun to be explored in human patients, but the basis of this therapy has been confirmed in animal models. Visceral Fat, however, is located in the abdomen underneath the muscle and around vital organs. The pair proved the bacterium Helicobacter pylori causes inflammation, then ulcers.Some 20 years after their discovery, and having endured a storm of criticism from the medical establishment, the pair was awarded the Nobel Prize for Medicine. Immune cells are dispatched to fight the inflammation, and then cholesterol is laid down over the wound like a Band-Aid. Inflammation of kidneys is known as nephritis and may cause kidney failure or high blood pressure. For someone else, the genetic weak link may make them prone to cancer or Crohn’s Disease. Some of the best foods for vitamin C: guava, bell peppers, oranges, grapefruit, strawberries, pineapple, kohlrabi, papayas, lemons, broccoli, kale, brussels sprouts, kidney beans, kiwi, cantaloupe, cauliflower, red cabbage, mangos, and mustard greens. Today’s diets contain a large amount of salad dressings and processed foods made with vegetable oils, and these provide an overdose of omega-6 fatty acids.
However, an increasing number of heterozygous mutations during early development have been identified, especially in diseases affecting intellectual disability [2]. Search operations are on,” a senior IAF official told media persons over telephone from New Delhi.
Unchecked inflammation in the pancreas can cause both pancreatitis, a potentially fatal disease, and type 1 diabetes, in which the pancreatic islet cells that produce insulin are destroyed.
As the level of AGEs buildup, cells start to signal the production of inflammatory cytokines. The nervous system represents an immensely complex structure in which the orchestrated control of gene expression (partially due to epigenetic control) faces its major challenge. As new members of the epigenetic machinery are described, the number of human syndromes associated with epigenetic alterations increases [6].
The understanding of the contribution of epigenetic change to rare disorders and common neurological disorders will hopefully provide us with better molecular tools for an improved diagnosis, prognosis and therapy of these patients in the future.
Inflammation of the small airways that transport air to the lungs may cause an asthma attack or chronic bronchitis. While drugs usually block a single target molecule and reduce its activity dramatically, he says, natural anti-inflammatories gently tweak a broader range of inflammatory compounds.
Some interesting data: 3 of 4 genes are expressed in the brain [3], and it expresses more alternatively spliced transcripts [4] and miRNAs [5] than any other tissue. As recent examples, mutations of histone demethylases and members of the non-coding RNA machinery have recently been associated with Kabuki syndrome (mutations in JMJD3), Claes-Jensen X-linked mental retardation syndrome (JARID1C mutations) or Goiter syndrome (DICER mutations). The complexity of the nervous system makes it especially sensitive to epigenetic disturbances, and consequently, many mental disorders are caused by mutations in the epigenetic machinery.




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