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The American Diabetes Association released statistics in June of 2014 from the National Diabetes Statistics Report.
There are two primary types of diabetes.  Type I is when the body is unable to make enough insulin and insulin injections are the conventional form of medicine used to treat this disease. With this impending doom, what can we do?  We can each take responsibility for our own health, and do what is necessary to change our lifestyle to prevent contracting diabetes.  The most important things research shows us is that with just 30 minutes of physical activity 5 days a week and healthier eating, we could dodge diabetes. Healthcare PolicyAssess the impact of a changing regulatory environment on your business with analysis of the latest changes in policy. Pricing & ReimbursementStay ahead of the ever changing global pricing landscape with in-depth analysis of industry developments and pricing trends. Research & DevelopmentRead about the latest drug trials, releases, and industry developments – and understand how they will affect market pricing and access.
Tresiba, a basal insulin, was recently launched by NovoNordisk in Japan(the drug was approved in Europe in October 2012). In-spite of this hoopla there are many facets of treatment paradigm, often overlooked, within diabetes with patient adherence being at the top. In spite of this aggressive treatment strategy, there are some fundamental challenges which need immediate attention to make the treatment more effective and engaging. Over the years, the evolution of insulin production and administration has been quite astonishing. The evolution of insulin is not only limited to the method of production but also to the mode of delivery. There is no doubt that the overall quality of care has improved in diabetes in the last 50 years, but there is a greater need to increase patient adherence which has remained stubbornly low. Diabetes is a challenging disease to manage and the most difficult challenge for physicians in diabetes management is the regimen adherence, which is extremely crucial for glycemic control.
This multidimensional adherence regimen with different components poses a dilemma for the ongoing clinical practice. According to results of the DAWN study, patients rate the clinical efficacy of insulin as low and would blame themselves if they had to start insulin therapy – an attitudinal factor affecting adherence to overall therapy.


Both attitudinal and behavioural factor poses a unique dilemma in engaging the patient effectively towards therapy. According to a recent study published by The American Journal of Pharmacy Benefits, in US alone, the inflation adjusted per-capita non-adherence cost of diabetes ranges from $4007 to $6100 (approximately).
According to our team’s research with American Diabetes Association, Diabetes has reached epidemic proportion in the US with nearly 26 million adults and children living with the disease.
No wonder that with figures like these, there is global outcry in healthcare systems to reduce the overall cost burden.
In the case of diabetes, there is no doubt that the overall treatment paradigm has greatly evolved in the last decade with better drug delivery systems and genetically enhanced insulin products making patient’s lives better.
Praful Mehta is a senior life sciences analyst for IHS and is responsible for the development of new tools, platforms and capabilities. About the Life Sciences BlogIndustry insights from the IHS Markit Life Sciences team covering market access, pricing and reimbursement, emerging markets, generics strategies, therapeutic development pathways, forecasting and market sizing, and general competitive intelligence. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. The company has hailed the drug as better than existing insulin products, with a lower risk of hypoglycaemia, and as offering the promise of a better quality of life. It is normally used by all patients with type-1 diabetes and when diet and other oral drugs have failed to manage the blood sugar in the body for patients with type-2 diabetes. It has undergone a tremendous change - from multiple injections routines to twice daily regimen to continuous subcutaneous insulin infusion through pumps. According to the research published in the Journal of Clinical Diabetes, it has been shown that diabetes regimen is multidimensional, and adherence to one regimen component may be unrelated to adherence in other regimen areas. However, a closer analysis of therapeutic component reveals interesting insights on patient adherence. However, patients who are not managing their diabetes well (poor perceived control, more complications, and diabetes related distress) are significantly more likely to see insulin therapy as potentially beneficial – a behavioural factor affecting adherence to therapy.
One common factor (acknowledged by both physicians and patients) attributable to the low adherence rates and directly affecting patient engagement is the frequency of administration.


Poor adherence usually leads to lower success rates for treatment to target levels, increased adverse clinical outcomes (especially CV related), and overall mortality. An additional 79 million have prediabetes, placing them at increased risk for developing type 2 diabetes. However, it is ironic that in the advent of reducing overall healthcare cost, governments are so concerned about the benefits coverage, product pricing, and deep budget cuts but are completely ignoring patient adherence.
It ensures a win-win solution to all the stakeholders in the healthcare system - improving quality of life for patients, increasing access to medicines for the pharmaceutical industry, reducing healthcare costs through systemic savings, and ensuring an overall better quality of human life. Praful has been a long-time advisor to senior teams within the pharma industry on issues of market competitiveness, business integration, and commercialization strategies. However, there is a growing trend amongst specialists for adopting the early use of insulin in type-2 diabetes treatment pathways. Then, scientists came up with technological breakthrough to prepare recombinant human insulin in E.coli bacteria--commonly known as synthetic insulin.
Pharmaceutical companies have been very active in inventing better methods of drug delivery, reducing the overall dose frequency and launching re-usable delivery systems, to increase overall adherence. Patients taking a once-daily dose have reported a greater compliance than compared to those taking three or more doses of medication.
Non-adherence also leads to increased utilisation of systemic healthcare resources and greater costs for all the stakeholders.
Moreover, Diabetes caused $245 billion dollars of total healthcare expenditure in 2012, as compared to $174 billion dollars in 2007.
Even slight improvements in adherence could bring substantial systemic cost savings in the long run.



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