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Introduction: Type 2 Diabetes is a lifestyle related disease and a major risk factor for Cardio Vascular Diseases (CVDs).
Objectives: To estimate the prevalence of Type 2 Diabetes and Prediabetes among adults (aged 30 years and above) residing in Neyyattinkara taluk of South Kerala and to identify the diabetes Case Detection Rates across different age groups. Whereas rest of India is still grappling with communicable diseases and malnourishment, the state of Kerala stands out, with non-communicable diseases (NCDs) emerging as a major public health challenge. To estimate the prevalence of Type 2 Diabetes and Prediabetes among adults (aged 30 years and above) residing in Neyyattinkara taluk of South Kerala. To study the fasting plasma glucose levels as an indicator of diabetes control in the community. Data Collection Tools: Structured questionnaire and Blood Sugar examination using Glucometer (DiabeCHECK- Jitron).
Ethical clearance was obtained from Institutional Ethical Committee, Trivandrum Medical College. Diabetes Case Detection Rates across different age groups were examined and was highest (76%) between 60 and 69 years.
81 (18%) persons had blood sugar values above 125 mg%.  Of these 42 were already diagnosed and was on treatment. A national study9 to determine the prevalence of Diabetes and Prediabetes in India done in three states (Tamil Nadu, Maharashtra and Jharkhand) and one union territory (Chandigarh) showed that the weighted prevalence of Diabetes was 10.4% in Tamil Nadu, 8. Studies from Kerala  also emphasized the need for life style modifications and community based programmes for early detection and preventive measures.1, 12  Diabetes Case Detection Rate in the present study was 50% in persons less than 50 years of age and more than 75% above the age of 50 years. Prediabetes is a significant risk factor for the development of type 2 diabetes, micro vascular, and macro vascular disease.
Prevalence of Goiter among Primary School Children of Kulgam District, Jammu & Kashmir, IndiaS. Scientists have discovered that one of the most diabolical proteins implicated in diabetes not only kills insulin-producing cells through one mechanism, but also damages the cells it doesn't kill through a second, novel mechanism.
Reigning in this rogue protein, called TXNIP, could significantly control diabetes, a disease that affects nearly 9 percent of Americans and is rapidly becoming a major cause of death and disability worldwide.
The scientists, from the University of Alabama at Birmingham, identified several never-before-realized routes to target TXNIP with drugs.
Diabetes is a disease characterized by high levels of sugars in the blood, often resulting in cardiovascular disease, kidney disease and nerve damage, and can lead to the loss of limbs.
Type 1, once called juvenile diabetes, is usually diagnosed in children – their pancreatic beta cells die or malfunction for no known reason. The protein TXNIP, short for thioredoxin-interacting protein, is involved in both type 1 and type 2 diabetes. Apoptosis would be good for, say, cancer cells or cells infected with pathogens, which is why the body has such a defense mechanism, but it clearly isn't good for beneficial beta cells. In her most recent research, Shalev along with lead author Guanlan Xu of UAB and colleagues found that TXNIP also can tell the beta cells to make less insulin. However, elevated blood sugar levels are known to cause an increase in TXNIP, and over time, even small increases in blood sugar levels can lead to accumulation of TXNIP and the associated beta cell dysfunction and death that can eventually lead to diabetes, she said. Urano's research has revealed that excessive TXNIP is produced as a result of stress on a cell structure called the endoplasmic reticulum (ER). Health experts say that a diet rich in fiber and complex carbohydrates found in leafy green vegetables, legumes and whole grains can help prevent type 2 diabetes. Of the 26 million people who have diabetes, an estimated 7 million have no idea that they have the disease, according to the American Diabetes Association. A recent study in “The Journal of the American Dental Association” found that one in five cases of total tooth loss in the United States can be linked to diabetes. Regardless of your health status, the ADA recommends everyone practice good oral health habits by brushing twice a day for two minutes with fluoride toothpaste, flossing daily, eating a healthy diet and visiting your dentist regularly. The not-for-profit ADA is the nation's largest dental association, representing 157,000 dentist members.

According to a recent online article For Most, Diet and Exercise Alone Not Sufficient Obesity Treatment Method, Top Journal Says by the American Society for Metabolic and Bariatric Surgery (ASMBS) it says that diet and exercise alone is not sufficient in the treatment of obesity. Aloha SurgeryALOHA Surgery is a comprehensive metabolic surgery program that offers the Gastric Bypass, Vertical Sleeve Gastrectomy, and General Surgery. Hepatic encephalopathy is a serious complication that patients with cirrhosis of the liver can experience. A new study published in the official clinical practice journal of the American Gastroenterological Association specifies that probiotics are an effective preventative measure impacting on gut bacteria. The study consisted of administering probiotics to patients who showed risk factors for hepatic encephalopathy, but had yet to experience an obvious episode, vs a placebo a group who did not receive probiotics. The effectiveness of the current available treatment consisting of lactulose, a nonabsorbable disaccharide, is limited by side effects (diarrhea, bloating and gas) and a narrow therapeutic window.
Manish Kumar Lunia, Barjesh Chander Sharma, Praveen Sharma, Sanjeev Sachdeva, Siddharth Srivastava. Clinical symptoms and biomarkers of chronic distal symmetrical sensory peripheral neuropathy. Figure 1: Clinical symptoms and biomarkers of chronic distal symmetrical sensory peripheral neuropathy. Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA.
All three authors provided substantial contributions to discussions of the content of the manuscript, researched the literature, and participated in writing, editing and revision of the manuscript. A very limited number of published studies indicate high prevalence of Type 2 Diabetes in the state of Kerala.
Ltd).  Calibration was done daily to ensure reliability and new pairs of DC cells were used every day.
All Prediabetic were educated regarding lifestyle modifications for Diabetes prevention and motivated to follow up in local Primary Health Centres.
Lifestyle change in Kerala, India: needs assessment and planning for a community-based diabetes prevention trial. Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Evaluation of non communicable disease control pilot programme of National Rural Health Mission in Thiruvananthapuram district.
High prevalence of type 2 diabetes mellitus and other metabolic disorders in rural Central Kerala. Prevalence and risk factors of diabetes in a community-based study in North India: the Chandigarh Urban Diabetes Study (CUDS). Cluster randomised controlled trial of a peer-led lifestyle intervention program: study protocol for the Kerala diabetes prevention program. Screening Performance of Diabetes Risk Scores Among Asians and Whites in Rural Kerala, India. Normally, the pancreas produces insulin in its beta cells to shuttle sugars, or simple carbohydrates, from the foods we eat into various organs, where it is used for fuel.
Type 2, sometimes called adult-onset diabetes, usually develops during adulthood and is strongly associated with obesity or a diet high in sugars and processed foods, although sedentary lifestyles and hereditary factors are also at play. Anath Shalev, director of the UAB Comprehensive Diabetes Center and senior author on the new paper, discovered nearly a decade ago that TXNIP is activated by sugars and kills beta cells. This is done through a never-before-seen mechanism, she said, in which TXNIP triggers the beta cells to make a snippet of genetic material, called microRNA-204, that interferes with another molecule, called transcription factor MafA, which would otherwise turn on the insulin gene. This leads to an increase in blood sugar and greater levels of TXNIP production – a vicious cycle that results in even less insulin production and more beta cell death.
Once diabetes progresses, however, repairing damaged beta cells remains difficult to impossible. For Live Science, Christopher covers public health, nutrition and biology, and he occasionally opines with a great deal of healthy skepticism.

With those figures in mind, the American Dental Association (ADA) recommends that regular health care checkups may help to identify potential signs of diabetes. That, along with a longer healing process, makes them more susceptible to developing gum disease and developing a more severe form of the disease. The premier source of oral health information, the ADA has advocated for the public's health and promoted the art and science of dentistry since 1859.
Fowler believes that it’s about time we realize that obesity is not a lifestyle choice. The disease is characterized by confusion, altered level of consciousness and possible coma as a result of a liver failure.
The findings of this study revealed that the the incidence of hepatic encephalopathy was lower in patients treated with probiotics and that supplementation with probiotics was not associated with any side effects. Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial.
BennettGary Bennett is Professor and Canada Senior Research Chair in the Department of Anesthesia and the Faculty of Dentistry at McGill University, Montreal, QC, Canada and Adjunct Professor in the Department of Anesthesiology at the University of California, San Diego, CA, USA. This study was done in the Neyyattinkara taluk of south Kerala by including coastal, mid land and high land regions to make it representative of the geographical profile of the state.
She found that TXNIP can unleash a wave of molecules called free radicals that tell the beta cells to commit cellular suicide in a process called apoptosis. The ADA's state-of-the-art research facilities develop and test dental products and materials that have advanced the practice of dentistry and made the patient experience more positive. Sinai Hospital in New York, whose research focuses on obesity prevention and treatment for adolescents said “the average adult with sustained obesity has less than a 1% chance” of returning to and maintaining a healthy body weight without surgery. It is a multifactorial biologic condition independent of the flawed thinking that people just need to exercise more and eat less. It is caused by accumulation in the bloodstream of toxic substances that are normally removed by the liver. Skin punch biopsy often reveals a significant loss of sensory axons from the epidermis (intraepidermal nerve fibres), even in cases where electrodiagnostic studies are normal. He received his PhD in psychology from Virginia Commonwealth University in Richmond, VA, USA, and spent 20 years as a staff scientist at the Neurobiology and Anesthesiology Branch, National Institute of Dental Research, NIH, Bethesda, MD, USA). Christopher has presented this book in more than 20 countries and has inspired the passage of laws to support worker meal programs in numerous countries.
The ADA Seal of Acceptance long has been a valuable and respected guide to consumer dental care products. Bariatric surgery is still underutilized despite significant evidence that it is the most effect treatment in obesity. For the past 35 years his research has focused on neuropathic pain syndromes and the development of new analgesics.Contact Gary J.
Christopher holds a Master of Health degree from Harvard School of Public Health and a degree in journalism from Temple University.
The monthly The Journal of the American Dental Association (JADA) is the ADA's flagship publication and the best-read scientific journal in dentistry.
He received his PhD from Saint Louis University for studying the inflammatory and biochemical mechanisms of septic shock, before his postdoctoral fellowship in the laboratory of Professor Daniela Salvemini researching the mechanisms underlying pain and pain therapeutics. She received her BSc in pharmacology from King's College, London, UK and her PhD in pharmacology under the mentorship of Nobel Laureate Sir John R. Her research focuses on the cellular and molecular changes that underlie chronic pain and opioid-induced analgesic tolerance.

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