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The University of Rhode Island Doctor of Pharmacy program is accredited by the Accreditation Council for Pharmacy Education. Inflammation and the presence of pro-inflammatory cytokines are associated with numerous chronic diseases such as type-2 diabetes mellitus, cardiovascular disease, Alzheimer’s disease, and cancer.
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA. At Sanofi Diabetes, our priorities are focussed on the needs of people with diabetes around the world. We want people to live 'beyond' diabetes, to achieve aspirations and to make the most of everyday!
SEARCH for Diabetes in Youth is a multicenter study funded by CDC and NIH to examine diabetes (type 1 and type 2) among children and adolescents in the United States. Diabetes can be treated and managed by healthful eating, regular physical activity, and medications to lower blood glucose levels. Many people with type 2 diabetes can control their blood glucose by following a healthy meal plan and a program of regular physical activity, losing excess weight, and taking medications. Blood glucose control reduces the risk of developing the eye, nerve, and kidney complications of diabetes. Hypoglycemia or low blood glucose is a complication of diabetes treatment with insulin or certain oral medications that can have serious consequences such as seizures, unconsciousness, or death.
Individual blood glucose targets, with the selection of targets based on the potential risks and benefits to the patient, are encouraged for people with diabetes.
Self-management education or training focuses on self-care behaviors, such as healthy eating, being active, adhering to medications, learning coping skills, and monitoring blood glucose. Many people with diabetes also need to take medications to control their blood pressure and to control their cholesterol.

Diabetes can affect many parts of the body and is associated with serious complications such as heart disease and stroke, blindness, kidney failure, and lower-limb amputation. In 2011, about 282,000 emergency room visits for adults aged 18 years or older had hypoglycemia as the first-listed diagnosis and diabetes as another diagnosis. In 2010, after adjusting for population age differences, hospitalization rates for heart attack were 1.8 times higher among adults aged 20 years or older with diagnosed diabetes than among adults without diagnosed diabetes.
In 2010, after adjusting for population age differences, hospitalization rates for stroke were 1.5 times higher among adults with diagnosed diabetes aged 20 years or older compared to those without diagnosed diabetes.
Diabetes was listed as the primary cause of kidney failure in 44% of all new cases in 2011. In 2011, a total of 228,924 people of all ages with kidney failure due to diabetes were living on chronic dialysis or with a kidney transplant. In 2010, about 73,000 non-traumatic lower-limb amputations were performed in adults aged 20 years or older with diagnosed diabetes. People with diabetes may have or develop other complications or conditions, such as nerve disease, non-alcoholic fatty liver disease, periodontal (gum) disease, hearing loss, erectile dysfunction, depression, and complications of pregnancy, among others. Diabetes was the seventh leading cause of death in the United States in 2010 based on the 69,071 death certificates in which diabetes was listed as the underlying cause of death. After adjusting for population age and sex differences, average medical expenditures among people with diagnosed diabetes were 2.3 times higher than people without diabetes. An overwhelming amount of data indicates that curcumin, a polyphenol obtained from the ground rhizomes of the popular Indian spice turmeric, Curcuma longa L, is a potential therapeutic agent for treating cancer and other chronic inflammatory diseases. Another critical part of diabetes management is reducing cardiovascular disease risk factors, such as high blood pressure, high lipid levels, and tobacco use. Medications for each individual with diabetes will often change during the course of the disease.

Older patients with type 2 diabetes and children with type 1 diabetes are at particularly high risk for adverse outcomes associated with hypoglycemia. Studies have found that only about 35% to 40% of people with diabetes who died had diabetes listed anywhere on the death certificate and about 10% to 15% had it listed as the underlying cause of death.
Patient education and self-care practices also are important aspects of disease management that help people with diabetes stay healthy. Also, early detection and treatment of complications can prevent progression, so monitoring with dilated eye exams, urine tests, and foot exams is essential. Recently, a novel curcumin formulation, a solid lipid curcumin particle (SLCP) (Longvida®) was shown to have increased bioavailability in human volunteers. Because the risk of cardiovascular disease is increased in diabetes and prediabetes, blood pressure and lipid management, along with smoking cessation, are especially important. The NF-kB signaling pathway has been well characterized and is considered to be a predominant signaling pathway in inflammation. The goal of this study is to evaluate the effects of a standardized SLCP preparation against generic curcumin extract on inflammation through NF-kB  pathway.
Diagnosed diabetes was determined by self-report among survey respondents and by diagnostic codes for American Indians and Alaska Natives.
The tests used to diagnose diabetes vary in who they identify as having diabetes or prediabetes. More information is available about the tests that are used to diagnose diabetes and the test limitations.

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