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British-Swedish drugmaker AstraZeneca has been approved by the FDA for its once-a-day Xigduo XR extended-release tablet to treat adults with type 2 diabetes mellitus in the United States. The Xigduo FDA approval gives the two anti-hyperglycaemic agents, dapagliflozin and metformin, a green light to be used as a once-daily oral tablet. SGLT2 inhibitors are a new class of medicines that remove glucose from the body through the kidneys. However, safety worries have thus far limited uptake for the SGLT2 class, as the treatments have been linked to increased rates of genital and urinary tract infections, plus kidney damage and cardiovascular issues.
LGM Pharma provides the two anti-hyperglycaemic agents dapagliflozin and metformin hydrochloride for research and development purposes, and offers clients continued support throughout the R&D process. Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). This entry was posted in Anti-Diabetic, Blood Glucose Regulator, FDA Approved 2014, OTC and Compounding Product, Therapeutic Classification and tagged Australia, type 2 Diabetes by admin.
No one in the world may like to scratch or prickle all the time, but this is one condition, that most of the diabetic patients, have to face throughout their life. But, all thanks to the pharmacy companies and these anti-itching ointments, diabetics can take a deep breath of relief and relax a bit, as these ointments are easily available and can be applied on the affected area, to get instant relief. But, have you ever given a thought, as to what are the causes behind this diabetic itching?
Before we explain these causes, the first thing to be understood is that, diabetes in itself is not responsible for itching, neither is it a side effect of diabetic medications. There are certain bacteria like Staphylococcus that can cause infections on the skin, resulting in swelling, rashes and itching. Although, these bacteria can infect any person exposed to them, but the diabetic patients tend to get infected more, than the normal people.
Fungal infections are generally seen on those areas of the body that remain moist for long time, like foot, toes, armpits etc.
The other most common fungal infections that cause itching in diabetic patients include athlete’s foot, ring worm and jock itch, in addition to the genital infections. Some people are allergic to certain things, like some specific drugs, needles, insect bites, some particular foods, and even to the insulin. Another condition that diabetic patients suffer most often is poor circulation of bloodin their body. Sometimes diabetics face the problem of peripheral nerve damage, in which case, the peripheral nerves, mostly in legs and feet, of the person get damaged.
Atherosclerosis is a condition, wherein the arteries of the person thicken, and is most commonly found in the diabetic patients. The skin conditions like dry or overly moist skin can also cause rashes and itching in the diabetic patients. First and foremost, there are two types of Diabetes, and they are very different from one another. Diabetes is a serious health condition that not only affects your lifestyle, but puts you at risk for other health conditions including high blood pressure, stroke, and nerve damage.  Many Americans are at risk for type 2 diabetes, and the numbers are growing yearly.
One change that I always recommend to my clients when we discuss lifestyle-eating, and healthy living options that can be made, is to give up soda.


People often look at me, horrified.  They would rather I ask them to nibble on a pigs ear!  Here are some facts for you about regular and diet sodas and what they do to your body and your mind. But many people with Diabetes are not aware that uncontrolled blood sugar can lead to problems relating to their oral health. There’s a correlation between high blood glucose levels and an increased risk of gum disease. In addition, the areas around the teeth become populated with bacteria (and subsequent infections) and this in turn leads to an increase in blood sugar.
Fact: Diabetics are more susceptible to bacterial infections and a decreased ability to fight bacteria that enter the gums. This all comes back to our overall Wellness and how we all need to work on every aspect of ourselves…our mind, body and soul.
Insulin is a polypeptide hormone secreted by beta cells of islets of langerhans that play important role in controlling the sugar levels of the body. Numerous types of insulin are available in the market having a difference in onset of action, peek plasma level and duration of action. Short acting insulin is given to the diabetic patient during the 30 to 60 minutes of a meal taken.
This type of insulin can be mixed with short and rapid acting insulin that can cover the need of body for half of a day or overnight. Mixed insulins can be administered by a patient two to three times a day before the time of meal. Enter your email address to subscribe to this blog and receive notifications of new posts by email. AstraZeneca’s once-daily tablet is indicated as an adjunct therapy to diet and exercise to improve glycaemic control. Dapagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2) and metformin hydrochloride is a biguanide, which decreases glucose production and improves the body’s response to insulin. As a result, peak sales estimates for the class of drugs have been erratic, with some pegging their potential north of $5 billion and others expecting cumulative revenue more in line with $2 billion a year.
Type 2 diabetes is the most common form of diabetes affecting patients globally, and the United States alone has over 23 million people suffering from this condition. Itching has become almost synonymous with the symptoms and side effects of diabetes, and there seems to be no respite from it. May be not, but it is necessary to know as well as understand these factors that may result in itching. In fact, as we know, diabetes enhances all other medical conditions, and increases their severity; same is the case with itching.
These bacterial infections are a major cause for itching in diabetics, and can be treated by applying some creams or taking some pills. The most frequently spotted fungus, causing infections and rashes in the diabetic people, is Candida albicans.


So, if you are diabetic and are having any kind of allergies, then these allergies may also surface in the form of itching and you need to immediately rush to the doctor.
This poor circulation often hardens the blood vessels and narrows them down, resulting in insufficient availability of blood to the lower body parts, which may result into severe itching. This results into burning and itching sensation, in the affected areas, and need immediate medical help. This condition leads to poor supply of blood to the skin cell, which results in skin damage, again resulting into severe itching.
Poor blood circulation, and yeast infection may also cause rashes in the skin of such patients, leading to itching. Many people engage in a variety of defenses and excuses when faced with the diagnosis of Type 2 Diabetes.
Whether the patient is diagnosed with Type 1 or Type 2, the health care issues involved are painful and costly.  Peripheral neuropathy is a painful and difficult to treat complication of diabetes.
If your blood sugar levels are not controlled, then this can lead to such systemic disorders as heart disease, stroke and kidney disease. And not only do the gums become infected, but we also tend to lose the bone that is holding onto the roots of the teeth.
Infections lead to an increase in blood sugar and this makes the diabetes harder to control…again…a vicious circle. Sometimes patients may suffer diabetes mellitus type 1 and type 2 due to abnormality in insulin secretion or a reduction in the sensitivity of cells towards insulin. Then after a long battle, Eli Lilly and Boehringer Ingelheim finally won approval for empagliflozin.
Continued research and development of new and innovative treatments to combat this ever growing patient population is not only prudent, but also extremely necessary. This is a fact that, diabetics have to face the problem of itching more, as compared to other people, but these problems can be kept under control, or reduced to quite an extent, by maintaining proper sanitation, hygiene and regular exercising. Unfortunately, ignoring the information isn’t an answer that will help or resolve anything.
Meanwhile, Pfizer and Merck are still working through late-stage trials with the competing ertugliflozin. Also, don’t forget to slip an anti-itching ointment, in your pocket or purse, whenever you go anywhere, to come in handy, at the time of need.



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Comments

  1. Joe_Black

    I've never done this in my life!) and how effectively medications help lower your blood the Atkins.

    19.01.2015

  2. Togrul

    With diabetes, it's higher to eat rely upon further longer-term research.

    19.01.2015