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They found a lower rate of prostate cancer among people with diabetes, German, Swedish and U. The researchers could only speculate about the causes, Study leader Kari Hemminki at Helmholtz Association of German Research Centres in Heidelberg said.
Hemminki and colleagues studied the cancer incidence in 125,126 Swedish citizens hospitalized due to type 2 diabetes complications as well as those of the general population in Sweden.
It was also found by them that they also found higher risks of several cancers in those with type 2 diabetes, very significantly for pancreatic cancer and liver cell cancers. Diabetics also had double risk of cancers of the kidneys, thyroid, esophagus, small intestine and nervous system. Published in The Oncologist, the study also looked at whether the risk was higher in hospitalized diabetic patients because their tumors were found earlier due to routine diagnostics.
I know, being a man, I don’t go to the doctor as much as others would hope including my doctor. A 2004 study in the Journal of the American Medical Association analyzed data on 29,342 men and found that guys who had 21 or more orgasms a month were about 30 percent less likely to develop prostate cancer than those who racked up only four to seven a month.
For the 1,324th time, eat more cooked tomato products to reduce your risk of prostate cancer.
Men with the highest blood levels of trans fats have more than twice the prostate-cancer risk of men with the lowest levels. Androgen deprivation therapy (ADT) with Luteinizing hormone releasing hormone analogues or bilateral subcapsular orchiectomy is the mainstay of treatment in high risk localized and metastatic prostate cancer along with other modalities.
Although its use has resulted in improved survival in some patients, ADT has negative consequences [4]. Studies show that short-term ADT (3–6 months) results in development of hyperinsulinemia without causing hyperglycemia and long term ( 12 months) ADT reveal higher risk of incident diabetes and metabolic syndrome compared with controls [6,7]. The possible mechanism for increased risk of diabetes and cardiovascular diseases in patients on ADT is that ADT results in a decline in lean body mass and an increase in fat mass, subsequently this adiposity via elaboration of adipokines and inflammatory cytokines results in hyperinsulinemia and hyperglycemia [10]. The search criteria for studies had to be either complete articles of prospective, randomized, controlled trials or retrospective if these were well controlled. The patients had to have histologically confirmed adenocarcinoma prostate cancer and have received androgen deprivation therapy either, medical or surgical after the radical prostatectomy or radiotherapy and as monotherapy in metastatic disease.
The outcome measures were risk of incident diabetes, risk of cardiovascular diseases and non prostate cancer mortality. We determined the risk of incident diabetes and cardiovascular diseases based on the follow up period mentioned in each trial.
Publication bias was evaluated using the funnel graph, the Begg-Mazumdar adjusted rank correlation test [14], and the Egger test [15]. The electronic search revealed 344203 relevant citations, among which 752 diabetes and androgen deprivation therapy related studies were selected.
All four studies with population of 1, 15,119 patients, analyzed the cumulative risk of diabetes and cardiovascular diseases as one of the outcomes. The result of the test for heterogeneity was not statistically significant (p=0.14) as shown in Fig. All the included studies with patients number of 1, 15,119, examined the non prostate cancer mortality as one of the outcomes. The increased risk of incident diabetes and cardiovascular diseases and related mortality after ADT has remained controversial; there are no guidelines to prevent these complications.
One criticism of our meta- analysis can be the possibility of type 1 (? error) or false positive results; care was taken to reduce this error by using Hunter-schmidt's approach, in which the effect size error is divided by the square root of the reliability coefficient of the dependent variables. Looking at literature, androgen suppresion therapy (ADT), is beneficial in prostate cancer; the range of its metabolic complications is increasing, especially incident diabetes, cardiovascular morbidity and associated mortality, which warrants the active involvment of diabetologists in cancer care. In view of this meta-analysis and magnitude of the problem of prostate cancer and relatively frequent use of androgen deprivation therapy, it is important for oncologists to be aware of common side effects, prevention, and treatment to improve quality of life and reduce morbidity and mortality in patients with prostate cancer and need for frequent diabetic and cardiac screening as a part of multi-modality discipline. According to the 2014 Cancer Report provided by the Maryland Department of Health and Mental Hygiene, the incidence rate of prostate cancer in Maryland for 2011 (the most recent data available) was approximately 110 per 100,000 white men and 191 per 100,000 black men.  Mortality rates in Maryland due to prostate cancer were approximately 17 per 100,000 white men, and 37 per 100,000 black men. Current screening guidelines for prostate cancer emphasize the importance of making an informed decision.  In May 2012, the United States Preventative Task Force issued a final recommendation statement on the use of the prostate-specific antigen (PSA) screening test for prostate cancer. Men at higher risk of prostate cancer should have a conversation with their health care provider by age 45 to determine what, if any, screening tests are recommended. Although it is not yet known how to prevent prostate cancer, current studies suggest that having a healthy diet, being physically active, not smoking, and maintaining a healthy weight can help lower the risk of many types of cancer, while also reducing the risk of heart disease, diabetes, and stroke. For more information about prostate cancer, visit the Centers for Disease Control and Prevention website.
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The researchers separately analyzed how many cancers occurred in study participants after one and five years, respectively, following their hospital stays. The data were estimated using 1,048 prostate cancer cases and 1,120 controls from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial44, and 1,196 diabetes cases and 1,337 controls from the Health Professionals Follow-up Study45.
Now that we have to have insurance of some kind and the fact that we’re paying for it, I guess we should use it more.
They found that men who drank six or more cups of regular or decaf coffee were 59 percent less likely to develop advanced prostate cancer than those who eschewed the brew. What’s more, among survivors of prostate cancer, those who exercised vigorously (playing tennis, running, swimming, or biking) for 5 hours a week had a 56 percent lower risk of death from the disease. In studies on lab animals, the omega-3 fatty acids DHA and EPA in fish oil inhibited tumors. Trans-fatty acids increase inflammation and insulin resistance, both of which may play a role in prostate cancer. All these things I need to do a lot more of, especially ditching the Doughnuts, and working out. However, due to unavailability of national based cancer registries, its exact incidence or prevalence is not known in our country. A recent population-based study found that men undergoing ADT with luteinizing hormone releasing hormone (LHRH) analogues had a higher risk of incident diabetes, coronary artery disease, myocardial infarction, and sudden death. For the categorical variables, weighted risk ratios and their 95% confidence intervals (95%CI) were calculated using comprehensive meta-analysis software. For heterogeneity we performed the Cochran’s Q test to determine whether the studies are homogenous.
Meta-analysis of four prospective trials in prostate cancer showing increased risk of incident diabetes, cardiovascular diseases with long term androgen deprivation therapy. This was the reason to take up this meta-analysis, with the basic purpose of obtaining a large enough sample size from different studies, to reveal a possible significant difference between long term androgen deprivation therapy (medical or surgical) and no or short term androgen deprivation therapy in terms of incident diabetes, cardiovascular diseases and non prostate cancer mortality in prostate cancer patients. Adibul Hasan Rizvi, Director Sindh Institute of urology & transplantation (SIUT) for his constant support and bestowing us with state of art oncology department offering services to poor patients, free of cost and with dignity.
Virtual simulation and treatment verification–merits and demerits: experience at Sindh Institute of Urology and Transplantation (SIUT), Pakistan. Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer.
Complications of androgen-deprivation therapy in prostate cancer: the other side of the coin.
Prostate cancer survivorship: prevention and treatment of the adverse effects of androgen deprivation therapy.
Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer. Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer. The effect of hormonal therapy for prostate cancer on the electrocardiographic QT interval: phase 3 results following treatment with leuprolide and goserelin, alone or with bicalutamide, and the GnRH antagonist abarelix. Association between androgen-deprivation therapy and incidence of diabetes among males with prostate cancer. Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. Risk of cardiovascular mortality in prostate cancer patients in the Rotterdam randomized screening trial.
The effects of induced hypogonadism on arterial stiffness, body composition and metabolic parameters in males with prostate cancer. Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinemia.
Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy.
A randomized controlled trial of an exercise intervention targeting cardiovascular and metabolic risk factors for prostate cancer patients from the RADAR trial.
The leading risk factor for prostate cancer is age – 97 percent of prostate cancer cases occur in men age 50 or older. It concluded that the expected harms of PSA screening are greater than the potential benefit. It is essential that men communicate with their health care provider about the risks and benefits, as well as their personal values and preferences, to ensure that they are making an informed decision. This revealed a slightly lower risk elevation, but, the researchers concluded, the trend was the same.

Plus, Harvard researchers found that men who ate fish three times a week reduced their risk of aggressive prostate cancer by 25 percent. Avoid commercially baked doughnuts and cookies, as well as packaged baked goods containing hydrogenated oil. We reported that majority of patients in Pakistan present with advanced and metastatic stage (70%); only 30% of cases were localized or locally advanced [2]. Few prospective studies with reasonable longer follow up of ADT have documented the timing of onset of these complications and strategies to prevent those complications [8].
In contrarst surgical castration (orchiectomy) was associated only with a higher risk of diabetes [11].
In this meta-analysis, we selected all well controlled prospective studies with enough sample size and reasonable follow up published till date.
Continuous androgen-deprivation therapy increased risk for diabetes and fragility fractures in older men with prostate cancer.
Mary’s Animal Welfare League (SMAWL) will offer $15 rabies vaccinations for dogs, cats and ferrets from 6 p.m. The dashed line represents an analysis that further assumes that the logarithm of odds of disease is a linear function of the number of risk alleles. I don’t think that will change my habits about going to a doctor unless something seems really wrong.
While protecting your prostate, you can also help your noggin with the right amount of fish oils. Androgen deprivation therapy (ADT) is used along with radiotherapy and surgery in localized or locally advanced cases and as a monotherapy in metastatic cancer [3].
Some centers have adopted a practice of doing the baseline and serial screening for fasting glucose and other cardiac risk factors in prostate cancer patients receiving ADT and in selected cases, glucose tolerance testing and cardiac evaluation [9]. The increased risk of cardiovascular events with LHRH analogues could be partly because of pure drug effect, because these have been shown to possess arrhythmogenic potential [12]. These terms were then combined for search for prospective, retrospective, randomized, controlled, review and meta-analysis. The pooled analysis showed increased risk of diabetes and cardiovascular diseases and associated mortality.
Having a close relative with prostate cancer and being African American, or Caribbean of African descent, increases a man’s risk for prostate cancer. Another retrospective study using a claims-based database showed that prostate cancer patients on ADT were 36% more likely to develop incident diabetes compared to non-ADT patients [13]. But the discrimination of any test based on these genetic profiles is poor, partly because most people in the population have nearly average risk (that is, they carry a mix of risk and protective alleles).Part B shows the receiver operating characteristic (ROC) curves for prostate cancer and type 2 diabetes genetic profiles based on currently known, replicated loci14, 48. Interestingly majority of these incident diabetes and cardiovascular events were self reported.
The ROC curve is a commonly used summary of the discriminatory ability of a continuous biomarker14. Well, if you’re a man their a few things that you can do to help you reduce the risk of prostate cancer.
Each point represents a test defined by a different fixed cut-off number of risk alleles (k): those with more than k risk alleles are defined as high risk and those with k or fewer risk alleles are defined as low risk. For example, the third point from the left on the prostate cancer ROC (Ba) corresponds to a test with k = 8; the rightmost point corresponds to the (trivial) test with k = 0.
Mary’s County Health Department 13 hours ago August is National Immunization Awareness Month, highlighting the importance of vaccinations throughout our lifetime. Immunizations have significantly reduced the incidence of many serious infectious diseases and are considered to be one of the top 10 public health accomplishments of the 20th Century. A profile with C = 0.5 has no discriminatory ability, whereas a test with C = 1 has perfect discriminatory ability. Although the sets of markers we have used do not include all known risk markers for prostate cancer or type 2 diabetes, recent reports on type 2 diabetes have found very similar C statistics for genetic profiles with more loci12. Thus our success in developing genetic profiles that by themselves have good discriminatory ability will be limited by the underlying genetic architecture of the disease and our success in identifying many of the contributing loci. It will be important to test whether new markers provide improvements in discriminatory or predictive accuracy (measured by the C statistic or another metric50, 51) beyond existing risk factors, many of which are relatively inexpensive to measure.

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