Diabetes and its effects on the cardiovascular system,project m installer,should a diabetic drink rum xo - Good Point


In Diabetes Type 1 the body is not producing insulin, while in Diabetes Type 2 the cells are not responding properly to the insulin, and there is not enough insulin being produced. When ever food enter in our body ,Food get converted into the Glucose and because of insulin it enter and adsorb by the our body so the insulin is the main part and factor by which our body can absorb the glucose. Insulin, a hormone, is produced by Beta cells in the Islets of Langerhans, which are in the pancreas. So if you have diabetes then your body or bloodstream will not absorb Glucose properly or not at all absorb so this activity resulted high amount of Glucose and one the amount of glucose got high level than this situation called hyperglycemia.
When the cell of body does not respond to insulin than this situation is called Diabetes Type 2. So when body is not able to get proper energy and continuously increasing the level of Glucose than it a time people to get worry and rush to your doctor. So basically so cannot reduce Diabetes Type 1 through exercise because the beta cell has already destroyed. The major quantity of diabetes patient has Diabetes Type 2 (Approx 85 %) and patient usually seems  over weight and unfit.This kind of diabetes comes late in the life and it is very uncommon to find Diabetes Type 2 in 20s age people. Guys here we have written what we can but if you and your dear one is suffering from diabetes type 1 or diabetes type 2 than you must rush towards doctors and for you later on we will also publish the home remedies to cure diabetes.
At the center of the hemoglobin molecule is a heme group, with an iron atom at the center of it. As it goes through the body, hemoglobin gives up its oxygen to the various cells it comes in contact with. When this wonderful oxygen transport from your lungs, through your heart to the rest of your body is messed up for some reason, you have anemia. I used one of my own prior CBC reports to illustrate white blood cell counts in my last article.
If I were a CLL patient with red blood cell issues, RBC can be much lower than these healthy reference ranges. Anemia is easy to diagnose but not as easy to explain since it can be caused by many different things.
Once again, I cannot over emphasize the importance of not getting fixated on any one number but looking for overall trends. MCHC is the average hemoglobin concentration of packed red cells expressed as a percentage. In CLL patients with sharply lower RBC – perhaps because of AIHA or some of the other reasons discussed below, the bone marrow will register this fact and try to compensate by producing more red blood cells to replace the ones being lost. There are specific reasons for anemia in CLL, over and above the general reasons (poor diet, physical blood loss etc) discussed above. When the problem is too few red blood cells, patients are transfused with “packed red cells” – not whole blood.
The risk of infection using standard issue packed red cells is trace levels of viruses (hepatitis is one of the biggest risk factors) that can hide out in the donor white blood cells. Irradiated and leukoreduced blood products are a tad more expensive than the garden variety blood products, but not prohibitively so, and definitely not as expensive as the complications patients can run into if the wrong products are used.
As with most things, too frequent red blood cell transfusions carry the risk of iron overload. You are right that poikilocytosis is the term given to somewhat mis-shapen red blood cells. There are many different reasons why red blood cells can be misshapen, not all of them well understood. I listed Vitamin B1 deficiency in the table under reasons for low hemoglobin, therefore anemia. About two weeks ago my Hemoglobin went rapidly down to 7, so I needed a transfusion to get a better one.
I read that erythrocyte concentrates are the better the newer they are and that older ones are from a poorer quality and in so far bad for hosts. Blood banks have very strict guidelines on how long they can keep blood products before they are past their shelf life, so I would not worry about it.
LynnS: My maternal grandfather died, like your mother, of complications of aplastic anemia after 6 years or so of blood transfusions. Both my primary care and Oncologist recommended low dose asprin therapy for me as a preventative step to future cardiac events. Low dose aspirin is likely a good thing to do except for those with aspirin allergy, very low platelet counts or problematic coagulopathies such as Von Willebrands disease, hemophilia, etc. I would love to know more about the spleen and liver and how it copes with a huge mount of lymphocytes eg: 200K. You do a great service in guiding us in the art of knowing when to panic and when to wait out the lower or higher than normal numbers on our blood work and what it all means. CLL Topics Updates does not provide medical advice and its contents are for information only.
The following page will help you to learn the basics about coronary artery disease, also known as CAD and Coronary Heart Disease. Coronary artery disease is the leading cause of death in the United States for both men and women. Plaque is made up of fat, cholesterol (ko-LES-ter-ol), calcium, and other substances such a fibrin that circulate in the blood. When your coronary arteries are narrowed or blocked, oxygen-rich blood can’t reach your heart muscle. Heart attack occurs when blood flow to an area of your heart muscle is seriously compromised or completely blocked.
Over time, CAD can weaken the heart muscle and lead to heart failure and arrhythmias (ah-RITH-me-ahs). With the continued rise of artery disease anyone with a functioning brain should be asking WHY because the rise in artery disease would definitely suggest that mainstream medicine strategies simply aren’t working very well. There are quite a few risk factors that come into play in regards to coronary heart disease. The main or most common symptoms of coronary artery disease are angina (chest pain) and shortness of breath.


Coronary artery disease treatment of course depends upon who your doctor is and what he or she thinks is the best approach. Lower Blood Pressure Grape seed extract lowers blood pressure and this is great news for those who wish to lower moderately high blood pressure without toxic heart drugs.
Since anemia is a common side effect of CLL and causes significant loss of quality of life, we need to learn about it. Over the years I have seen many thousands of patient CBC reports, people seem to like sending me stuff and ask me to read the tea-leaves. Take out all the water in the red blood cells and pretty much the only thing left is hemoglobin. We said if you take a tube of fresh blood and spin it around fast in a centrifuge, the red blood cells will settle to the bottom and that this layer is just under half the volume of blood in the tube.
There is a range of sizes in red blood cells, not all of them are exact copies of each other. It is a derived number, you can calculate MCH by dividing the total amount of hemoglobin by the number of RBC, then multiply by ten to make the units work. You can calculate it by dividing the total amount of hemoglobin by the hematocrit, multiply by 100 to get percentage.
Many of the chemotherapy drugs used to treat CLL are “myelosuppressive” – meaning they damage or reduce the production capacity of stem cells to produce more myeloid cells – red blood cells are part of the myeloid line. The only choices at that point are stem cell transplant with healthy stem cells from a willing donor, or a lifetime of blood transfusion dependency. These are chemical messengers that alert the bone marrow to low RBC; marching orders as it were, that tell the marrow to gear up and increase production. One of the most common autoimmune diseases in CLL is AIHA (autoimmune hemolytic anemia), where perfectly good red blood cells are targeted and destroyed by the body’s own immune system gone berserk. The red blood cells are separated from blood plasma and from the other cells such as platelets, white blood cells etc by simple process of centrifugation. So, most blood banks recommend using irradiated and leukoreduced blood products for transplant patients as well as patients with any level of immune dysfunction. I had reason to learn all about this while my husband was going through his stem cell transplant and needed frequent transfusions. Each of those healthy new red blood cells coming into the body carries its own iron atom, and too many transfusions can cause too much accumulation of iron in the body of the patient. The reason for this low Hemoglobin is not yet identified but some reasons like bone marrow infiltration with CLL or autoimmune disease ore some viruses could be excluded. I am in W&W but this seems counter intuitive as asprin thins the blood and would seem to impact platlets. I have been anemic and you explanation of causes and the meanings of the CBC has been very helpful.
When plaque builds up in the arteries, the condition is called Atherosclerosis (ATH-er-o-skler-O-sis). This blockage, most often caused by a clot or plaque rupture, prevents oxygen-rich blood from reaching that area of heart muscle and causes it to die.
Heart failure is a condition in which your heart can’t pump enough blood throughout your body. Some like aging and genetics are without solutions but the majority can be eliminated with lifestyle changes. A family history of heart disease is associated with a higher risk of coronary artery disease, especially if a close relative developed heart disease at an early age. High blood levels of LDL cholesterol can increase the risk of atherosclerosis and plaque formations. Unrelieved stress may damage arteries as well as worsen other risk factors for coronary artery disease. This disorder causes you to repeatedly stop and start breathing while you’re sleeping.
C-reactive protein (CRP) is a normal protein that appears in higher amounts when there’s inflammation in your body.
Homocysteine is an amino acid your body uses to make protein and to build and maintain tissue. This substance forms when a low-density lipoprotein (LDL) particle attaches to a specific protein. Both angina and shortness of breath usually occur during or right after exercise however, your first symptom could be a heart attack. First line of defense is usually life style changes however lifestyle changes could also be coupled with drug therapy. Heck, blood is red because it is full of red blood cells.  Next obvious question, what makes red blood cells red? When hemoglobin comes in contact with oxygen in your lungs, oxygen gets attached to the iron atom.
And as you can see from the reference interval given for healthy individuals, I am doing OK on this front.  Reference ranges are even more important in the case of red blood cells because they are different for men and women.
Remember, just because you have CLL does not give you a pass, a get-out-of-jail-free card from all the other things that go wrong with people as they age. Hematocrit is the volume of red blood cells in a sample of blood, reported as a percentage. For example, newly minted red blood cells are just a bit bigger than older RBC that have been around the block more than a few times.
If there is a robust number of new red blood cells being made, as well as old ones hanging around, RDW will be a high number because the range of sizes of the cells present is broad. If there are so many CLL cells in the bone marrow that the ‘factory’ is packed to the rafters with these cancerous cells, there is no room left for healthy production of other cells to make up for losses due to normal wear and tear. If the damage is temporary in nature, production will gradually recover and RBC counts will head back up gradually. AIHA can be detected by Direct Coombs test and looking for antibodies targeting red blood cells.
While getting any blood product carries some risk of infection, this risk can be minimized by taking proper precautions.


Leukoreduced means they put the packed red blood cells through another step of purification, where the last remnants of white blood cells (“leukocytes”) are removed, since viruses hang out in white blood cells.
You can read the details by visiting “Harvey’s Journal”, the on-line blog we maintained so others can learn from our experience through this difficult period of our lives. But this is not something to worry about unless we are talking of patients who are chronically transfusion dependant. I will pass this on to my family as well.I tell them knowledge is wisdom and we need all the wisdom we can muster with this disease. It has been one of the most useful aids in helping me and my Doctors see trends in the progression of my disease. Coronary artery disease is a condition in which plaque (plak) builds up inside the coronary arteries.
Angina is chest pain or discomfort that occurs when there is NOT enough oxygen-rich blood flowing to an area of your heart muscle. Without quick treatment, a heart attack can lead to serious heart damage that ends up causing more complications such as ventricular tachycardia (V-tach or VT), heart failure and even death. Your risk is highest if your father or a brother was diagnosed with heart disease before age 55, or your mother or a sister developed it before age 65.
Carbon monoxide can damage their inner lining, making them more susceptible to atherosclerosis.
When grouped together, certain risk factors put you at an ever greater risk of coronary artery disease.
Sudden drops in blood oxygen levels that occur during sleep apnea increase blood pressure and strain the cardiovascular system, possibly leading to coronary artery disease.
But too much may increase clumping of platelets, the type of blood cell largely responsible for clotting.
Sometimes doctors skip the lifestyle changes and drugs and go straight to the surgical procedures in advanced cases where the other therapies look to be useless. Answer: because red blood cells have a molecule in them called hemoglobin (also spelled as haemoglobin if you are Brit, and abbreviated to Hb, Hgb or Hg) and hemoglobin is colored a bright cherry red when it is rich in oxygen, but more bluish red in color when it has been stripped of its oxygen. After picking up this precious hitchhiker in the lungs the blood next goes to the heart – the pumping station which circulates blood throughout your body.
In my case, the hemoglobin level is a tad low, below the reference range for my lab and hence it is flagged.
A low hematocrit usually indicates decreased production, excessive loss, or destruction of red blood cells. Cell size can also change depending on dietary issues – B12 and folic acid deficient red blood cells are larger than iron deficient cells.
A small RDW number suggests there is no extraordinary amount of red blood cells being made in the bone marrow. This may suggest that in spite of the obvious and  crying need for increased production of red blood cells, the bone marrow is not able to oblige.
The remedy is to clean out the bone marrow with appropriate therapy to kill the CLL cells there. Treatment options include prednisone, Rituxan, chemotherapy drugs, spleen removal – some or all of the above, as it becomes necessary. It can also be caused by a digestive disease, such as celiac disease, in which case the treatment may be treating the underlying celiac disease. I have used multiple institutions, some of which still log in values by hand on crude charts. Women who smoke at least 20 cigarettes a day have a  six times greater risk than do women who’ve never smoked. For example, metabolic syndrome, a cluster of conditions that includes elevated blood pressure, high triglycerides, elevated insulin levels and excess body fat around the waist, increases the risk of coronary artery disease. High levels of lipoprotein (a) may be associated with an increased risk of cardiovascular disease, including coronary artery disease and heart attack. Then there are those who think outside the box and learn how to not only prevent coronary artery disease but how to reverse it, get rid of it!
Did you know hemoglobin is present to the tune of 95-97% by dry weight of red blood cells (if water is counted, then the weight percentage of hemoglobin is around 35%). This oxygenated version of hemoglobin is bright red – which is why arterial blood leaving the heart is bright red. I am a bit anemic, possibly due to low level of iron in my food (I am a vegetarian) and poor absorption of what iron there is in my diet due to early stage Crohn’s disease. Perhaps the marrow is choke full of CLL cells and with the best of intentions the marrow cannot produce new red blood cells because of the infiltration, or perhaps the bone marrow is just not getting the message.  More about this further down.
I too have a mild case of poikilocytosis, because of underlying Crohn’s disease (a kind of autoimmune ulceration of the GI tract).
The pain also may occur in your shoulders, arms, neck, jaw, or back (between the shoulder blades).
Think of red blood cells as little sacks full of water and hemoglobin and you will be right on the mark. Depleted oxygen supply to the cells is slow suffocation, and that is exactly what it feels like.
Once the hemoglobin has given up its oxygen to the cells it picks up the waste byproduct of cellular breathing, namely carbon dioxide. Venous blood returning to the lungs and heart is bluish red in color because hemoglobin with carbon dioxide attached to it is bluish red in color. None of the hemotologists I see or my primary MD seem concerned and I have not gotten much of an explanation for it.



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