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A foot infection by and large involves extreme biomechanical complexities causing it, and tissue loss contaminated by foreign substances like bacteria, fungus, virus, yeast, or mold. Ingrown toenails problem can turn worse by wearing tight shoes that press against the flesh harder. To treat thrush naturally limit consumption of sugar, milk, starchy vegetables, processed meat, alcohol, nuts, mushrooms and food products containing yeast.
The Lactobacillus strains present in probiotic food products and supplements can fight Candida growth in the mouth and tongue. People on antibiotics or medications that suppress the immune system can reduce their risks of developing oral Candida infection by taking probiotic supplements. To boost your body’s resistance against oral fungus, take vitamins and minerals that help to strengthen the immune system. Vitamins A, C, D and E are especially recommended for improving immune response.
Grapefruit seed extract contains antifungal compounds. It also helps to stimulate the immune system, enhancing its ability to prevent growth of the Candida fungi. There are several causes of cramp among which the most common are dehydration, hyperthyroidism, diabetes, muscle fatigue, flatfeet, overweight, imbalances of electrolytes, etc.
Increase the amount of milk and yogurt intake as muscle cramp may happen due to calcium deficiency.
Boil some raspberry leaf in water and drink the water every day in the morning at empty stomach.
At the center of the hemoglobin molecule is a heme group, with an iron atom at the center of it. As it goes through the body, hemoglobin gives up its oxygen to the various cells it comes in contact with. When this wonderful oxygen transport from your lungs, through your heart to the rest of your body is messed up for some reason, you have anemia.
I used one of my own prior CBC reports to illustrate white blood cell counts in my last article. If I were a CLL patient with red blood cell issues, RBC can be much lower than these healthy reference ranges. Anemia is easy to diagnose but not as easy to explain since it can be caused by many different things. Once again, I cannot over emphasize the importance of not getting fixated on any one number but looking for overall trends. MCHC is the average hemoglobin concentration of packed red cells expressed as a percentage. In CLL patients with sharply lower RBC – perhaps because of AIHA or some of the other reasons discussed below, the bone marrow will register this fact and try to compensate by producing more red blood cells to replace the ones being lost. There are specific reasons for anemia in CLL, over and above the general reasons (poor diet, physical blood loss etc) discussed above. When the problem is too few red blood cells, patients are transfused with “packed red cells” – not whole blood.
The risk of infection using standard issue packed red cells is trace levels of viruses (hepatitis is one of the biggest risk factors) that can hide out in the donor white blood cells.
Irradiated and leukoreduced blood products are a tad more expensive than the garden variety blood products, but not prohibitively so, and definitely not as expensive as the complications patients can run into if the wrong products are used. As with most things, too frequent red blood cell transfusions carry the risk of iron overload. You are right that poikilocytosis is the term given to somewhat mis-shapen red blood cells.
There are many different reasons why red blood cells can be misshapen, not all of them well understood. I listed Vitamin B1 deficiency in the table under reasons for low hemoglobin, therefore anemia. About two weeks ago my Hemoglobin went rapidly down to 7, so I needed a transfusion to get a better one. I read that erythrocyte concentrates are the better the newer they are and that older ones are from a poorer quality and in so far bad for hosts. Blood banks have very strict guidelines on how long they can keep blood products before they are past their shelf life, so I would not worry about it. LynnS: My maternal grandfather died, like your mother, of complications of aplastic anemia after 6 years or so of blood transfusions. Both my primary care and Oncologist recommended low dose asprin therapy for me as a preventative step to future cardiac events. Low dose aspirin is likely a good thing to do except for those with aspirin allergy, very low platelet counts or problematic coagulopathies such as Von Willebrands disease, hemophilia, etc.
I would love to know more about the spleen and liver and how it copes with a huge mount of lymphocytes eg: 200K. You do a great service in guiding us in the art of knowing when to panic and when to wait out the lower or higher than normal numbers on our blood work and what it all means. CLL Topics Updates does not provide medical advice and its contents are for information only. In some cases, this pain can be quite debilitating and may handicap a person for a temporary period. The cool contact on the skin can relieve the pain by dulling the pain signals sent by nerves to the brain.
Diet is an important part of natural treatments. The first step in to switch to anti-inflammatory diet. Vitamin B12 is a necessary compound that should be maintained at optimal levels when you suffer from this condition.
Swimming is a great exercise which not only keeps you fit but also does not hurt your feet.
Cutting the edges of toenails sharp and straight will inhibit them from growing into the skin. The cotton should not be big making it stick out from the toenail at the same time ensure that it is not too small either. You accept that you are following any advice at your own risk and will properly research or consult healthcare professional. Also known as, oral Candida infection, thrush occurs when the balance of the microorganisms in the mouth is disrupted owing to certain diseases, medications or stress. Supplements and herbal remedies are frequently used for strengthening the immune system and inhibiting growth of the fungi.


They work by restoring the normal microbial balance in the mouth and stimulating the immune system. The antifungal property of garlic is attributed to ajoene and other sulfur containing compounds. Both children and adult suffer from muscle cramp and especially at night during their sleep.  Muscle cramp may occur on any part of the body though leg is the most common area of cramp.
Through sweat we lose most of the minerals from our body and imbalance of electrolytes happen.To get rid of it takes a glass of normal water. If you cannot stand the smell at all then take 4-5 cloves of garlic and fry them in mustard oil. Drink chamomile tea at least twice or thrice daily to get the benefit. Follow these tips sincerely and soon get remedy in muscle cramp. Since anemia is a common side effect of CLL and causes significant loss of quality of life, we need to learn about it. Over the years I have seen many thousands of patient CBC reports, people seem to like sending me stuff and ask me to read the tea-leaves. Take out all the water in the red blood cells and pretty much the only thing left is hemoglobin. We said if you take a tube of fresh blood and spin it around fast in a centrifuge, the red blood cells will settle to the bottom and that this layer is just under half the volume of blood in the tube. There is a range of sizes in red blood cells, not all of them are exact copies of each other.
It is a derived number, you can calculate MCH by dividing the total amount of hemoglobin by the number of RBC, then multiply by ten to make the units work.
You can calculate it by dividing the total amount of hemoglobin by the hematocrit, multiply by 100 to get percentage. Many of the chemotherapy drugs used to treat CLL are “myelosuppressive” – meaning they damage or reduce the production capacity of stem cells to produce more myeloid cells – red blood cells are part of the myeloid line. The only choices at that point are stem cell transplant with healthy stem cells from a willing donor, or a lifetime of blood transfusion dependency. These are chemical messengers that alert the bone marrow to low RBC; marching orders as it were, that tell the marrow to gear up and increase production.
One of the most common autoimmune diseases in CLL is AIHA (autoimmune hemolytic anemia), where perfectly good red blood cells are targeted and destroyed by the body’s own immune system gone berserk.
The red blood cells are separated from blood plasma and from the other cells such as platelets, white blood cells etc by simple process of centrifugation. So, most blood banks recommend using irradiated and leukoreduced blood products for transplant patients as well as patients with any level of immune dysfunction.
I had reason to learn all about this while my husband was going through his stem cell transplant and needed frequent transfusions. Each of those healthy new red blood cells coming into the body carries its own iron atom, and too many transfusions can cause too much accumulation of iron in the body of the patient. The reason for this low Hemoglobin is not yet identified but some reasons like bone marrow infiltration with CLL or autoimmune disease ore some viruses could be excluded. I am in W&W but this seems counter intuitive as asprin thins the blood and would seem to impact platlets. I have been anemic and you explanation of causes and the meanings of the CBC has been very helpful.
Food items that are rich in omega 3 fatty acids are considered anti-inflammatory in nature. Fish, fortified soy products, red meat, cheese and eggs are some examples of vitamin B 12 rich food stuff. Exercise also stimulates a healthy flow of blood especially to peripheral regions of the body. People wearing tight shoes, or having poor hygiene of the foot, long toes, short nails, any injury in the toenails, diabetes, abnormal nail growth, excess foot sweating, etc are prone to ingrown-toenails. If infection is severe, you may need to undergo a surgery to prevent death and decay of tissues. This will not only soften the toenails, but will protect ingrown toenails from infections as well.
Often keep checking that the cotton is in place and replace with another piece of cotton if it falls out. People with weakened immune system or diabetes have a higher risk of developing Candida infection in the mouth and tongue. The ideal diet for a person suffering from yeast infection should contain non-starchy fiber-rich vegetables, lean meat, fish and whole grains that do not contain gluten such as brown rice, millet and oat. You can also take supplements containing lactobacillus acidophilus or bifidobacterium to treat thrush. To treat Candida infection, you can eat fresh garlic or garlic supplements and apply garlic oil or paste to the affected areas. Heck, blood is red because it is full of red blood cells.  Next obvious question, what makes red blood cells red?
When hemoglobin comes in contact with oxygen in your lungs, oxygen gets attached to the iron atom. And as you can see from the reference interval given for healthy individuals, I am doing OK on this front.  Reference ranges are even more important in the case of red blood cells because they are different for men and women. Remember, just because you have CLL does not give you a pass, a get-out-of-jail-free card from all the other things that go wrong with people as they age. Hematocrit is the volume of red blood cells in a sample of blood, reported as a percentage. For example, newly minted red blood cells are just a bit bigger than older RBC that have been around the block more than a few times. If there is a robust number of new red blood cells being made, as well as old ones hanging around, RDW will be a high number because the range of sizes of the cells present is broad. If there are so many CLL cells in the bone marrow that the ‘factory’ is packed to the rafters with these cancerous cells, there is no room left for healthy production of other cells to make up for losses due to normal wear and tear. If the damage is temporary in nature, production will gradually recover and RBC counts will head back up gradually.
AIHA can be detected by Direct Coombs test and looking for antibodies targeting red blood cells.
While getting any blood product carries some risk of infection, this risk can be minimized by taking proper precautions.


Leukoreduced means they put the packed red blood cells through another step of purification, where the last remnants of white blood cells (“leukocytes”) are removed, since viruses hang out in white blood cells. You can read the details by visiting “Harvey’s Journal”, the on-line blog we maintained so others can learn from our experience through this difficult period of our lives. But this is not something to worry about unless we are talking of patients who are chronically transfusion dependant.
I will pass this on to my family as well.I tell them knowledge is wisdom and we need all the wisdom we can muster with this disease.
It has been one of the most useful aids in helping me and my Doctors see trends in the progression of my disease. Common causes of this medical condition are repetitive injury or trauma to feet, consumption of certain drugs and sometimes simply due to idiopathic reasons.
Some other medical conditions like kidney diseases, HIV AIDS, nutritional deficiency, multiple myeloma also cause this problem in many people.
Onces you know that it is pure pain due to inflammation or an aftermath of a wound that has healed completely then you can go for massage. Sea cod oil, salmon, mackerel, flax seeds, walnuts, basil, broccoli are some of the easily available food items that are high on omega3 fatty acids. Reducing the sugar content in the diet deprives the Candida fungus of its main energy source, which helps to reduce fungal growth. In addition to taking caprylic acid supplement, consider applying coconut oil to the tongue and mouth. To remove it, keep little amount of cold milk inside your mouth and rinse the mouth with it.
Answer: because red blood cells have a molecule in them called hemoglobin (also spelled as haemoglobin if you are Brit, and abbreviated to Hb, Hgb or Hg) and hemoglobin is colored a bright cherry red when it is rich in oxygen, but more bluish red in color when it has been stripped of its oxygen. After picking up this precious hitchhiker in the lungs the blood next goes to the heart – the pumping station which circulates blood throughout your body.
In my case, the hemoglobin level is a tad low, below the reference range for my lab and hence it is flagged.
A low hematocrit usually indicates decreased production, excessive loss, or destruction of red blood cells.
Cell size can also change depending on dietary issues – B12 and folic acid deficient red blood cells are larger than iron deficient cells.
A small RDW number suggests there is no extraordinary amount of red blood cells being made in the bone marrow. This may suggest that in spite of the obvious and  crying need for increased production of red blood cells, the bone marrow is not able to oblige. The remedy is to clean out the bone marrow with appropriate therapy to kill the CLL cells there.
Treatment options include prednisone, Rituxan, chemotherapy drugs, spleen removal – some or all of the above, as it becomes necessary.
It can also be caused by a digestive disease, such as celiac disease, in which case the treatment may be treating the underlying celiac disease.
I have used multiple institutions, some of which still log in values by hand on crude charts.
You may also take an icepack or frozen golf ball and place it under the feet where the pain emanates. Massage is best done as a follow up of warm water dip as it further soothes the relaxed muscles and alleviates the stiffness in the feet around the bone. However, before getting into an exercise regimen, do consult a physiotherapist who will give you a better idea and suggest various ranges of sitting and standing exercises. There have been several changes in the treatment strategies for a foot infection of late in the wake of pharmacologic and technological advancements; for instance, the introduction of plastic and reconstructive techniques for functional restoration of foot infections, and a subsequent reduction in amputation rates thereon. Did you know hemoglobin is present to the tune of 95-97% by dry weight of red blood cells (if water is counted, then the weight percentage of hemoglobin is around 35%). This oxygenated version of hemoglobin is bright red – which is why arterial blood leaving the heart is bright red.
I am a bit anemic, possibly due to low level of iron in my food (I am a vegetarian) and poor absorption of what iron there is in my diet due to early stage Crohn’s disease.
Perhaps the marrow is choke full of CLL cells and with the best of intentions the marrow cannot produce new red blood cells because of the infiltration, or perhaps the bone marrow is just not getting the message.  More about this further down. I too have a mild case of poikilocytosis, because of underlying Crohn’s disease (a kind of autoimmune ulceration of the GI tract). In most of the cases, doctors recommend nerve relaxers and anti-inflammatory drugs in the interim but these have their own set of side effects when taken over a long period of time. This is why avoid weight exercises and keep away from carrying any heavy weight even while continuing in your usual daily lives. Not only in summer when sweat is maximum, drink adequate water (10 glasses at least) in dry winter season also.
Think of red blood cells as little sacks full of water and hemoglobin and you will be right on the mark. Depleted oxygen supply to the cells is slow suffocation, and that is exactly what it feels like. In this feature we will introduce our readers to various ways of relieving themselves of these neuropathic pains of feet. Also in cases of diabetic patients, they must keep away from this remedy if they have any wounds or infection in the feet. Once the hemoglobin has given up its oxygen to the cells it picks up the waste byproduct of cellular breathing, namely carbon dioxide. Animal meat like liver, kidney and heart are non-vegetarian options of food items rich in lipoic acid.
If you do have some very flat soled shoes then go for insoles, that are easily available in most of the shoe stores. If your pain is occasional and well managed, then you may go for running as an exercise. Venous blood returning to the lungs and heart is bluish red in color because hemoglobin with carbon dioxide attached to it is bluish red in color. None of the hemotologists I see or my primary MD seem concerned and I have not gotten much of an explanation for it.



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