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Whether you’re restocking an entire order or just need a few more, Inkers make the process quick and easy. When Anu Kumar, 70, a chronic diabetic from Del-hi, heard of a trial which could lead to a biological cure for diabetes and make people like her insulin-free, she was hopeful. Most have Type 2 diabetes, where the body gradually loses the ability to process blood sugar, whereas those with Type 1 diabetes, which is hereditary, have their islet cells destroyed by the immune system. DRI’s global network of diabetes res-earchers wants to develop a biological cure for diabetes by restoring natural insulin production and normalizing blood sugar levels for them. In the trial on Wendy Peacock, islet cells from the pancreas were put within a bio-degradable “scaffold”. The donor islets are implanted into the scaffold and combined with the patient’s plasma and thrombin (an enzyme), creating a gel-like material that sticks to the omentum and holds the islets in place (see picture).


According to the DRI website, its researchers are focused on two platforms for a BioHub, a biodegradable scaffold and a bioengineered scaffold. The Transplantation of Human Organs Act, 1994, restricts donation only to first degree relatives of the recipient. Incidentally, it was only with the passing of the Transplantation of Human Organs Act, 1994, that transplants could be done from brain dead donors. The second hurdle, like all transplants, is for the recipient to accept the cells from the donor without the need for immune-suppressants all his life. Immune-suppressants are strong drugs which “suppress” the immune system and expose the patient to infections. Another issue with Type 1 diabetics is that as their immune system had attacked their islet cells, it leads to diabetes in the first place. However, this trail is still a breakthrough in the field of diabetes and India would do well to watch out for it. If you take a moment to read the testimonials below, you'll see how much it means to our customers to have one-of-a-kind custom shirts for their memorial events. On August 18, 2015, Wendy Peacock, a Type 1 diabetic from San Antonio, Texas, underwent a minimally invasive procedure whereby islets cells (insulin-producing cells) from a donor pancreas were transplanted to her body, leading her to produce her own insulin naturally for the first time. It is estimated that every three seconds, at least one patient develops diabetes worldwide. The US trial is being carried out only on those with severe Type 1 diabetes so that they can achieve insulin independence. This is implanted on the surface of the omentum, a tissue covering abdominal organs and which serves as a transplant site.
It is made of 10 percent silicone, while the rest is open space with tiny pores to house the islets. However, islet cells, he said, can also be taken from fetal, stem and animal cells, but these have not met with much success. It is still too early to know how long the implanted cells will continue to produce insulin without the need for these drugs.


Scientists are, therefore, trying to protect these transplanted cells by wrapping them in a tight coating and giving low-dose drugs only at the site of the transplant. This phenomenon is called “auto-immunity” and scientists are trying to see that it doesn’t happen again when the islet cells are transplanted to the omentum.
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This was part of a trial by the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine.
Meanwhile, new blood vessels are formed, which provide oxygen and other nutrients to the cells. It restricts donation of organs only to first degree relatives (immediate family) of the recipient. One of them, the beta cells, sense sugar in the blood and release the right amount of insulin so that normal levels are maintained. Even in the US, organ donation is critically low—about 1,700 pancreases were available in 2014—and would hardly suffice for those with diabetes. This has led to a severe shortage of organs, be it kidneys, liver, heart, lungs or pancreas.
However, in the case of Type 1 diabetes, the immune system attacks these beta cells, destroying them.
The body can no longer produce insulin, causing the patient to rely on those in the market.



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