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This site contains information, news and advice for healthcare professionals.You have informed us that you are not a healthcare professional and therefore we are unable to provide you with access to this site. November 1, 2010 by Emmanuelle Pinjon Leave a Comment Dr Deirdre Blake, consultant endocrinologist and medical advisor to Novo Nordisk, presents a comparison of efficacy and safety in the treatment of type 2 patients, with inadequate control on metformin. The last several years have seen the launch of a number of incretin-based treatments for type 2 diabetes mellitus (T2DM).
A study entitled ‘Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial’1 recently published in The Lancet, sought to compare liraglutide, a GLP-1 receptor agonist, in a head-to-head trial with sitagliptin, a DPP-4 inhibitor.
Individuals with T2DM sub-optimally controlled on metformin were invited to participate in the study. Interestingly, despite liraglutide being an injectable agent, the patient treatment satisfaction levels were significantly better with liraglutide 1.8mg than with sitagliptin. Do you agree that private hospitals should be paid via the NTPF to cut public hospital waiting lists?
With the announcement of Animas Vibe’s FDA approval in the United States and last week’s first shipments of Asante’s new MySnap reaching customers who designed the company’s first customizable pumps (myself included), it’s the perfect time for an insulin pump comparison.
I’ve been using an insulin pump since the year 2000 and in those 14 years, have used 10 different pump models from five different pump companies. Each of the six companies listed below is working hard to provide people with diabetes with innovative devices for pumping insulin. Pros: Integrated Enlite CGM with Low Glucose Suspend puts it on the pathway toward Artificial Pancreas. Takeaway: If you have loved the Medtronic pump for the last two decades, you’ll love and recognize this pump. Cons: Human factor issues (tiny screen, reliance on meter to use advanced features, difficult cartridge changes).
Takeaway: As the only tubeless option on the market, it’s just right for users wary of tubing. I have also experienced a massive decrease in pod failures during the past 6 months compared to my first few years using the pod.
Great review as a PA getting a patient view and comparison is extremely helpful since we have to know about all the equipment our patients. Would be EXCELLENT to also read potential problems with each Pump, Customer Service for each pump, etc.
My husband is diagnosed T2 Diabetes and he is in marketing field, so he has been prescribed to take Healthgenie Insulin Travel Wallet. I have been with Medtronic since I started my pump therapy almost 16 years ago and stick with them because they are the front runners in this market. I am small and slim and not used to carrying around something attached to my body at all times so I hate (yes, a strong word but it is how I feel) the lump in my clothing at all times. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes.
The Tiago looks decent in side profile.It gets a striking belt-line and a discreet crease on its C-Pillar. Even though the Tata kite is a code name but its much better name than Tata Glade,I will suggest go with Tata kite name. The gross outline of the distal aspect is similar to that of the mesial aspect (see Figures 11-9, 11-10, 11-13, and 11-14). Because of the tendency of the crown to taper distally on the buccal surface, most of the buccal surface of the crown may be seen in perspective from the distal aspect. The distal marginal ridge dips sharply in a cervical direction, exposing triangular ridges on the distal portion of the occlusal surface of the crown. The distal surface of the crown is generally convex, with a smoothly rounded surface except for a small area near the distobuccal root at the cervical third. A measurement of the crown buccolingually and mesial to the buccal and lingual grooves is greater than the measurement on that portion of the crown which is distal to these developmental grooves. The four major cusps are well developed, with the small minor, or fifth, cusp appearing on the lingual surface of the mesiolingual cusp near the mesiolingual line angle of the crown. The mesiolingual cusp is the largest cusp; it is followed in size by the mesiobuccal, distolingual, distobuccal, and fifth cusps.
An analysis of the design of the occlusal surfaces of maxillary molars may be summarized here. The triangular arrangement of cusps is reflected in the outline of the root trunks of maxillary molars when the teeth are sectioned in those areas.The distolingual cusp becomes progressively smaller on second and third maxillary molars, often disappearing as a major cusp (see Figure 11-11).
The occlusal surface, or occlusal table as it is sometimes termed, of the maxillary first molar is within the confines of the cusp ridges and marginal ridges. The two minor fossae are the mesial triangular fossa, immediately distal to the mesial marginal ridge, and the distal triangular fossa, immediately mesial to the distal marginal ridge (see Figure 11-l). The mesial marginal ridge and the distal marginal ridge are irregular ridges confluent with the mesial and distal cusp ridges of the mesial and distal major cusps.
The central fossa of the occlusal surface is a concave area bound by the distal slope of the mesiobuccal cusp, the mesial slope of the distobuccal cusp, the crest of the oblique ridge, and the crests of the two triangular ridges of the mesiobuccal and mesiolingual cusps. In the center of the central fossa, the central developmental pit has sulcate developmental grooves radiating from it at obtuse angles to each other. Starting again at the central pit, the central developmental groove is seen to progress in a mesial direction at an obtuse angle to the buccal sulcate groove. The mesial triangular fossa is rather indistinct in outline, but it is generally triangular in shape, with its base at the mesial marginal ridge and its apex at the point where the supplemental grooves join the central groove. An additional short developmental groove radiates from the central pit of the central fossa at an obtuse angulation to the buccal and central developmental grooves.
The distal fossa of the maxillary first molar is roughly linear in form and is located immediately distal to the oblique ridge.


The distolingual cusp is smooth and rounded from the occlusal aspect, and an outline of it, from the distal concavity of the distal marginal ridge to the lingual groove of the crown, describes an arch of an ellipse.
The lingual outline of the distolingual cusp is straight with the lingual outline of the fifth cusp, unless the fifth cusp is unusually large. Generally speaking, the roots of this tooth are as long as, if not somewhat longer than, those of the first molar (Table 11-2).
The crown of the maxillary second molar is 0.5 mm or so shorter cervico-occlusally than that of the first molar, but the measurement of the crown buccolingually is about the same.
Two types of maxillary second molars are found when the occlusal aspect is viewed: (1) The type that is seen most has an occlusal form that resembles that of the first molar, although the rhomboidal outline is more extreme. Sitagliptin for Patients with Type 2 Diabetes Who Did Not Have Adequate Glycaemic Control with MetforminDrawing Comparisons – Liraglutide vs. This trial was performed in centres across Europe and North America and was funded by Novo Nordisk, the manufacturer of liraglutide.
However, adverse events were higher with liraglutide, particularly gastrointestinal symptoms. A low rate of hypoglycaemia was seen with both agents, and liraglutide also led to significantly greater weight loss than sitagliptin.
Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Which you prefer depends on which features matter to you; one man’s pro is another man’s con.
Insulin that has sat adjacent to your natural body temp of 98 degrees is very likely to have denatured, meaning that the insulin has broken down and no longer works. My blood sugars are through the roof all the time with this piece if junk and it should not be on the market. It is my first pump after years of injecting and as I live in the UK it is funded entirely by our National Health Service (good) which means I have no choice of pump (bad). Looking at the dimensions, the smallest option you mention is the OmniPod but it is not very much smaller than the Animas considering the controller is separate. The petrol variant of the upcoming car is powered by a 1.2-litre, three-pot Revotron engine with a maximum power of 84 bhp and a peak torque of 114 Nm.
At this price point, theTiago will rival the likes of Alto K10, Chevrolet Beat, Maruti Wagon R, Maruti Celerio and the last gen Hyundai i10. This is because the buccolingual measurement of the crown mesially is greater than the same measurement distally. This concavity continues on to the distal surface of the distobuccal root, from the cervical line to the area of the root that is on a level with bifurcation separating the distobuccal and lingual roots. An outline of this root, when the tooth is viewed from the distal aspect, starts buccally at a point immediately above the distobuccal cusp, follows a concave path inward for a short distance, then turns outward in a buccal direction, completing a graceful convex arc from the concavity to the rounded apex. An outline following the four major cusp ridges and the marginal ridges is especially so (see Figures 11-1, 11-2, 11-12, 11-13, 11-14, and 11-17). Also, a measurement of the crown immediately lingual to contact areas mesiodistally is greater than the measurement immediately buccal to the contact areas. Developmentally, only three major cusps can be considered as primary, the mesiolingual cusp and the two buccal cusps.
Thus the triangular arrangement of the three important molar cusps is called the maxillary molar primary cusp triangle. The major fossae are the central fossa, which is roughly triangular and mesial to the oblique ridge, and the distal fossa, which is roughly linear and distal to the oblique ridge. The union of the triangular ridge of the distobuccal cusp and the distal ridge of the mesiolingual cusp forms it. The central fossa has connecting sulci within its boundaries, with developmental grooves at the deepest portions of these sulci (sulcate grooves). This pit is located in the approximate center of that portion of the occlusal surface that is circumscribed by cusp ridges and marginal ridges (see Figure 11-1).
The central groove at the bottom of the sulcus of the central fossa usually terminates at the apex of the mesial triangular fossa. Usually, it is considered a projection of one of these, because it is very short and usually fades out before reaching the crest of the oblique ridge. Two terminal branches usually appear, forming two sides of the triangular depression immediately mesial to the distal marginal ridge.
In the latter case the lingual outline of the fifth cusp is more prominent lingually (see Figure 11-17, 9). The distobuccal cusp is not as large or as well developed, and the distolingual cusp is smaller.
Incretin-based therapies are divided into two groups: glucagon like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors.
The results of this study add to the growing literature supporting the use of incretin-based treatments in T2DM. When I approach a pump, I want its rep to be able to explain features beyond the company’s marketing talking points. We are incredibly fortunate to have choices when shopping for a device we’ll depend on for the next four to five years. In my eyes, it is incredibly irresponsible to even suggest that a user violate this protocol. It needs to receive blood sugar readings from the sensor, give insulin, and make my life a little easier and it does just that.
The Tata Tiago seems to be a logical successor to the very successful, but now dated, Indica hatchback. However, one needs to remember that the mileage figures shown above are achieved under controlled conditions and may vary under normal usage.
Overall, the exterior features crisp lines and the Tiago has to be the most handsome car from Tata yet. The front gets a neat-looking bumper with wide air-dam and chrome-plated foglamp enclosures.


All of the decrease in measurement distally is a result of the slant of the buccal side of the crown. Thus it is apparent that the maxillary first molar crown is wider mesially than distally and wider lingually than buccally. At this site, however, traces of developmental lines are nearly always present in the enamel. The distolin-gual cusp is common to all of the maxillary molars; any other additional one, such as the cusp of Carabelli on first molars, must be regarded as secondary. The characteristic triangular figure, made by tracing the cusp outlines of these cusps, the mesial marginal ridge, and the oblique ridge of the occlusal surface, is representative of all maxillary molars. This ridge is reduced in height in the center of the occlusal surface, being about on a level with the marginal ridges of the occlusal surface. In addition, it contains supplemental grooves, short grooves that are disconnected, and also the central developmental pit. From this pit the buccal developmental groove radiates buccally at the bottom of the buccal sulcus of the central fossa, continuing on to the buccal surface of the crown between the buccal cusps. Here it is joined by short, supplemental grooves that radiate from its terminus into the triangular fossa.
When it crosses the oblique ridge transversely, however, as it sometimes does, joining the central and distal fossae with a shallow groove, it is called the transverse groove of the oblique ridge (see Figure 11-17, 3, 4, and 5).
These two sides, in combination with the slope mesial to the distal marginal ridge, form the distal triangular fossa.
The cusp ridge of the distolingual cusp usually extends lingually farther than the cusp ridge of the mesiolingual cusp. In describing this tooth, direct comparisons will be made with the first molar both in form and development.
The mean age of the participants was 55 years, the mean baseline HbA1c was 8.4 per cent, and the mean duration of diabetes was six years. Rates of infections were similar in the three groups and there were no cases of pancreatitis with either drug. Tata Motors took the wraps off the Tiago hatchback at a media event in Goa in December 2015. Thus, the new Tata model is fast catching up with the segment leader! The entry-level Tata Tiago Petrol costs INR 3.2 Lakhs. The diesel variant, on the other hand, gets a new 1.05-litre, three-cylinder Revotorq engine with a maximum power of 69 bhp and peak torque of 140 Nm. The very neatly executed clamshell hood adds some bulk to the car’s front-end design.
Among the highlights here are swept-back taillamps, a neatly sculpted boot-lid and a chunky rear-bumper.
With the Bolt failing to attract small car buyers, it is now the Tiago that can finally push its manufacturer’s sales in the private car market. Also, stay tuned to Car Blog India for more posts like our post on the Tata Tiago price details here. Sometimes it is crossed by a developmental groove that partially joins the two major fossae by means of its shallow sulcate groove. It connects with the lingual developmental groove at the junction of the cusp ridges of the mesiolin-gual and distolingual cusps.
The distolingual cusp is poorly developed and makes the development of the other three cusps predominate. At pharmacological concentrations this results in a relatively potent glucose-lowering effect, as well as other GLP-1 mediated effects such as suppression of glucagon secretion, delayed gastric emptying and decreased food intake.
Both the motors could get an automated manual transmission (AMT) at a later stage, but, for now, make do with a five-speed manual gearbox. Occasionally one or more supplemental grooves cross the mesial marginal ridge of the crown. These two grooves travel in the same oblique direction to the terminus of the lingual groove, which is centered below the lingual root at the approximate center of the crown lingually (see Figure 11-5, LDG).
This results in a heart-shaped form from the occlusal aspect that is more typical of the maxillary third molar (see Figure 11-26, 1 and 7).
DPP-4 inhibitors, on the other hand, are oral agents which act by preventing DPP-4 from breaking down endogenous GLP-1 and lead to more modest, physiological increases in GLP-1. If the fifth cusp development is distinct, a developmental groove outlining it joins the lingual groove near its terminus. Treatment satisfaction was assessed using patient questionnaires while safety assessments were also carried out, including collection of all adverse event data and self-reported hypoglycaemic episodes.
I want to know how fast it scrolls, how large a pack mule I’ll need for the supplies, and where they’ve buried the IOB. There are things that should be upgraded (the screen!) and I hope the enlite CGM is better than the previous system which I found to be worthless. Check out our detailed report below for information on Tata Tiago price details along with specifications, interior & exterior pictures, video review, features list and other details.
This means that there are enough chances of TATA giving some sleepless nights to its Japanese and Korean rivals. Any part of the developmental groove that outlines a fifth cusp is called the fifth cusp groove. If I had an issue, needed a replacement shipped over night, placing an order, asking for a discount on my bill, getting warranty accessories replaced for free, maybe I just talk really nice to them and they appreciate that. And the end result is that the pump wastes insulin by either leaking it from the cartridge or because loads have to be repeated.



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