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There’s no reason to fret though because the nodules associated with EN would just resolve within 6 weeks or so without any medical interventions. Acute – This is the common type of EN in pediatric patients and is usually associated with staphylococcal infections. There may be a series of symptoms involved in erythema nodosum before the tender, red bumps begin to show up. Flu-like manifestations – Initially, one may feel as if suffering from a bout of flu. These symptoms may be felt within a few weeks (or to some within a month) and those tiny, red, bumps would then begin to surface. Appearance of tender bumps – After several weeks of feeling generally unwell, painful nodules would then begin to appear.
Streptococcal infection – This is considered to be the leading cause of erythema nodosum in both children and adults.
Medication – There are medications that would trigger EN and these include the use of oral antibiotics as well as contraceptive pills.
Inflammatory Bowel Disease (IBD) – People with IBD like ulcerative colitis and Crohn’s disease are also at risk for developing EN. Pregnancy – Although this has not been fully understood, getting pregnant has been found to trigger EN. Sarcoidosis – The lymphs and the lungs are primarily affected by an inflammatory condition called sarcoidosis. Cancer – Certain types of cancer including leukemia and lymphoma may also be factors that trigger EN. Chest X-ray – This is primarily done to rule out the possibility of sarcoidosis or tuberculosis.
Biopsy – When all diagnostic procedures seem to be futile, a biopsy may be indicated. Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) – These medications are given to alleviate pain and discomfort. Potassium Iodide – Joint pains may be relieved with this drug though it has not been fully understood how this works. When it comes to diabetes many people are unaware about the risks and symptoms of the disease. Type-2 Diabetes occurs in people of all age groups, and early symptoms are subtle.In fact one out of two people suffering with type-2 diabetes don’t know that they have it. Although symptoms may not be seen in some individuals, it is better to know them and visit doctor if you feel that you are at risk.
Diabetes can cause damage to blood vessels which in turn causes sexual dysfunction in both males and females. In women if they have gestational diabetes when pregnant puts them at higher risk for developing type 2 diabetes later on. In healthy person insulin helps convert carbohydrates from food we eat to energy in an efficient manner. Glucose then enters the bloodstream, which stimulates the pancreas to release insulin in just the right amount. If the person is suffering with type-2 diabetes due to metabolism mishap the cells cannot absorb glucose properly. Simple Blood test reveals whether you have been suffering from diabetes or not.A1C blood test gives an overview of your blood sugar levels in past 2-3 months.
Fortunately diabetes can be managed; one can keep blood sugar levels under control by changing their lifestyle, food habits, keeping stress under control, controlling hypertension (if you have). Diet plays a major role in controlling blood sugar levels in a diabetic, ask your doctor for a diet plan according to your region and food habits.
The third and most important thing to manage is stress, people suffering from type-2 diabetes should manage stress.
When you are undergoing diabetes treatment, testing glucose levels in blood is very important. If we develop some healthy habits, lifestyle and manage medical conditions we can help prevent these odds from developing type-2 diabetes.
Making healthy eating habits,exercising,living a healthy lifestyle is the only way to stay prevented to some extent from diabetes.Thanks for reading.
In the UK there are currently over 3.5 million people who have diabetes, with a growth rate exceeding 280,000 people per year. Retinal image of right eye in type I DM with finger-count visual acuity (VA) and hyperglycemia: demonstrated severe macular oedema, exudates, neovascular, and numerous flame-shaped hemorrhage. There is a growing body of research which has found that diseases such as diabetic retinopathy and macular oedema are driven, in part, by lack of oxygen to the retina (retinal hypoxia). That demand for oxygen becomes even greater at night, rising by around 40% as rod photoreceptors dark-adapt. The body’s natural response to this is to promote new growth of blood vessels to compensate by releasing vascular endothelial growth factor (VEGF) but unfortunately these new vessels are weak and suffer from leakage of fluid which results in diabetic retinopathy and diabetic macular oedema.
It’s only going to get worse as the prevalence of diabetes rises, potentially by as much as 50 percent by 2030 in the UK, with obvious pharmaco- and socioeconomic implications. The current treatments for DR are pan-retinal photocoagulation or intraocular injections of anti-VEGF pharmaceuticals, which are both invasive, uncomfortable for the patient and very expensive, making them treatments of last resort.
Treatment via Laser photocoagulation is a treatment that effectively cauterises the affected and damaged blood vessels in the retina. The other treatment is an intra-ocular injection of anti VEGF drugs, which works against the vascular endothelial growth factor protein produced by retinal cells.


Clinical trial and study data has demonstrated that Noctura 400 has the potential to treat this condition at a fraction of the cost, creating the opportunity to provide an affordable and non-invasive treatment to the millions who are affected across the globe.
The treatment works on the principle of preventing the rods in the eye from dark adaptation, which reduces the oxygen demand of the eye at night, preventing hypoxia and the compromised blood vessel proliferation that can result in the retina. The Noctura 400 Sleep Mask consists of an OLED (Organic Light Emitting Diode) light housed inside a soft cushioned fabric mask, designed to be worn at night, to deliver a precise dose of light therapy during a patient’s normal hours of sleep. At the end of the allocated period (usually 12 weeks), the mask is returned for analysis and a replacement mask is provided. Today, treatment is only available when the DMO becomes clinically significant or shows progression to the fovea. Another treatment option is inhibitors of vascular endothelial growth factor (anti-VEGF) which are injected into the eye. The Noctura 400 Sleep Mask is a Class 2a medical device, which has CE certification, and its design and manufacture meet the standards of ISO13485. Noctura 400 has successfully completed clinical safety and efficacy trials and is currently in trial in over 35 NHS hospital clinics with more than 160,000 hours of recorded use. PolyPhotonix has had excellent support for the development of the Noctura 400, with peer reviewed grants totaling £14 Million over the past 5 years from Innovate UK, NHS, SBRI Healthcare and other sources.
PolyPhotonix, a rapidly growing SME, is committed to developing NE England based manufacturing and has established a significant part of the supply chain in the NE. PPX is also developing high volume manufacturing processes for the manufacture of OLED devices. The Noctura 400 Sleep Mask is currently available to patients privately through approved optometrists as well as through our national provider, The Outside Clinic, who provide a home optician service. On the Noctura web site there are a number of patient testimonials included as well as an OCT scan from a patient who has used Noctura 400, showing the before and after scans (during a 6 month period). With over 15 years’ experience in the field of medical research and printed electronics, Richard is well recognized as a pioneer in material science and its applications. With an early life as a successful artist in based in France, Richard has a thorough understanding of the creative process and a unique view on the development of markets for innovative research.
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It has also been additionally found that the female population is more affected with this condition with a current ratio of 1:4. This type of EN is classified as a septal panniculitis and is sometimes referred to as sub-acute nodular migratory panniculitis of Pinol and Vilanova or erythema nodosum migrans. The red bumps, usually measuring around 2-6 centimeters in diameter, have no defined margins and may be found anywhere in the body.
This is associated with the accumulation of tiny lumps of cells on the previously mentioned organs. Biopsy involves taking a sample coming from the nodules which would then be sent to the lab for further analysis. Potassium iodide is taken orally but is not considered to be a very effective form of treatment for some people. It is highly recommended that you raise your legs so as to decrease swelling and control pain. In this article we bring some insights about type-2 diabetes which is the most common type of the diabetes that occur in almost all the age groups.We also focus on everything you need to know about type 2 diabetes which is common in most people.
Insulin, a hormone, allows glucose to enter cells throughout the body, where it is used as fuel.
Symptoms include numbness, tingling, needles sensation often in fingers, hands, toes or feet.
As one can’t feel things properly due to nerve problems, it becomes to feel the injury that happens to feet. Always keep in mind that eating small meals frequently helps you manage your blood sugar levels under control than three large meals daily. Being active not only helps reduce fat, control sugar levels but also prevents heart disease risk. He is a passionate blogger, entrepreneur, Internet Marketing Expert who lives and breathes it. This condition is characterised by the leakage of fluid from compromised blood vessels within the central retina: 240,000 people (8%) with diabetes in the UK have clinically significant DMO and 100,000 people with DMO have visual impairment. RNIB data for 2015 quotes the number of people with Diabetes in UK as over 4 million, of whom over 1.1 million have background retinopathy and 128,725 have non-proliferative or proliferative retinopathy. The retina uses more oxygen per unit mass than any other tissue in the body due to the fact that photoreceptors have a phenomenally high metabolic rate.
They can only be given at a late stage in the development of these eye complications when patient’s eyesight is being severely threatened. The treatment is not permanent and delays the inevitable progress of the disease and also irreversibly damages photoreceptors. This treatment is provided within secondary care to later stage DR patients currently and costs in excess of £6,500 per eye per year. Noctura 400 has been designed as a preventative care treatment to stop the progression of diabetic macular oedema (DMO) and hence retain visual acuity.
Noctura 400, with its in-built monitoring and compliance functionality, was specifically designed as a monitored home-based therapy that could form the basis of a new care pathway, bridging the gap between primary and secondary care. The mask directs a low intensity light of a specific wavelength into the rod cells during sleep.
The mask is programmed to administer the correct dose of light each night as part of a continuing therapy; the mask also measures patient compliance.


The collected compliance data allows the clinician to compare how regularly the mask has been worn, with changes in vision and the condition of the disease.
Laser photocoagulation treatment is the standard of care when the DMO becomes clinically significant. These treatments are costly and cause significant burden to patients, their care-givers and the healthcare system. CE certification requires proof of efficacy as well as safety and as such is supported by a comprehensive technical file. Clinical trial have shown that it is highly effective when compared to current treatments showing a significant reduction or clearance of cysts in the subfield of maximum pathology. Much of the early safety & efficacy research and trials was undertaken at Liverpool University through Innovate UK*, KTP and KTN funding. They are actively preparing for Innovate 2015, the annual innovation conference showcasing other promising healthcare companies such as PolyPhotonix. PPX research, develop and manufacture photonic devices for various applications, including healthcare and we have a number of research programs underway in the UK, unfortunately we cannot discuss them publicly. He is a regular keynote speaker internationally and sits on a number of industrial and government advisory boards.
The prevalence of EN actually varies according to geographical location with 2.4 cases per 10,000 in England alone. Though this is oftentimes considered to be an isolated case, there are certain instances that this can be triggered by certain factors which may generally involve hypersensitivity of the immune system.
People suffering from diabetes have plague formation in their arteries which leads to blood clots and hardening of blood vessels further increasing the risk of stroke. Diabetic should be food conscious and carefully monitor intake of carbohydrates, fats, protein in their diet. Walking is a simple activity that anyone can do hence most doctors suggests people to walk 45 minutes daily.
So keep your stress under control, learn some stress reducing tips, we have posted earlier. They work either by increasing the insulin production or blocking the digestion of starches or both. Checking sugar levels often lets you know how controlled your sugar levels are and also helps you to speak with your doctor in your treatment. With the incidence of Diabetes set to increase by 50% between 2010 and 2030, there is a tsunami of costs facing both health and social care services.
People with diabetes commonly have microvascular damage, which can start to compromise retinal blood circulation and oxygen transport and once circulation is sufficiently compromised, the result is retinal hypoxia. The device is also a treatment for later stage at a much reduced cost to current treatments. Future adoption of the PPX technology for the preventative care of early stage DR patients offers a route to significantly reducing numbers of patients referred into the hospital eye service. It restores the rods to their daytime state, reducing the need for oxygen, avoiding the hypoxic responses and therefore preventing the progression of DR and DMO. Although laser treatment reduces the risk of moderate visual loss by 50% at this stage, it is not effective in restoring best corrected visual acuity (BCVA) and has significant side effects that impact on the patient’s quality of life. Phase III (CLEOPATRA) trials are underway in a number of other NHS hospitals (15+) as is the CANDLE (NICE MTEP) in another 15 NHS hospitals.
Richard and his company have won many international and national awards for innovation, research and business.
The nodules would typically resolve within a week but would also sooner be replaced with new ones. In this condition the body makes excess insulin but the muscles, cells, fat cells, liver don’t use the insulin properly. Your doctor may order to take random glucose and glucose test after 2 hrs of eating food also to determine the diabetes correctly. This results in severe damage to feet even for a small injury, if left undiagnosed small injury can lead to amputation. Strength training and aerobics also helps in your exercise routine, always talk to your doctor before starting any exercise. Relaxation techniques like meditation and breathing exercises are helpful and instantly bring down blood pressure to normal levels. Controlling the blood sugar levels in early stages is the only way to prevent oneself from reaching to such a condition.
This is also an idiopathic condition whose cause yet remains unknown but more recently linked to staphylococcal infections and sarcoidosis. And lastly, taking enough rest would greatly improve one’s condition by speeding the healing process. As soon as the nodules begin to heal, these would seem to appear like bruises turning their color from blue to yellow. One should not worry though because most people who previously suffered from erythema nodosum eventually recovered from it without having any complications.



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