Can diabetes be cured by stem cell therapy,ways to cure diabetes naturally food,diabetes food list spanish,herbs for diabetic ulcers quickly - PDF 2016


The proposal alone of using human embryonic stem cells for the purpose of medicinal research has caused intense debate among many political and religious groups. Embryonic Stem cells differ from other variances of stem cells due to their capability to replicate themselves in a laboratory indefinitely. In order to understand and analyse the results and progress of research into this field, it is imperative to understand why embryonic stem cells are being focused on a solution as opposed to other forms of stem cells.
Somatic (Adult) stem cells have been leading stem cell research in the past as it never necessarily conflicted with the majority of ethical or religious groups and their beliefs. In the placement of a culture, (Growth of cells in vitro in an artificial medium for research or medical treatment (The National Institutes of Health resource for stem cell research, 2009)), embryonic stem cells are able to divide infinitely and with relative ease in comparison to somatic cells.
From an outside perspective, it would appear that the possibilities are endless, and that embryonic stem cells could well become the 21st century penicillin. Regardless of the fact that research is in its premature stage, there have been encouraging reports.
Albeit, it may only be in mice but the results are very promising in particular because there were no tumours formed and with the brain cells releasing the vital catecholamine dopamine. On the other hand, there has been no embryonic stem cell research successfully tested on humans. Dr Ron McKay of the Laboratory of Molecular Biology and his colleagues described a series of experiments in which they induced mouse embryonic cells to differentiate into insulin-secreting structures that resembled pancreatic islets. Research conducted during the last decade has also provided more evidence that human embryonic cells can develop into cells that can and do produce insulin.
Possibly the most important finding in the last couple of years is that of Novocell who report that they managed to convert human embryonic stem cells into insulin-producing cells. Hair regrowth is a famous word often heard or seen in advertisements in television or paper. The idea seems to be working because many of know that stem cell is related to growth of new cells replacing the damaged ones. Researchers associated with the University of Pennsylvania School of Medicine successfully isolated stem cells that were required for hair growth.
These stem cells were transplanted into the adult mice and within a time period of 4 weeks the transplanted stem cells gave rise to new follicles which helped in the growth of new hair.
Although the actual treatment for human is still 10 years away, but it is for sure that those days are not far off when people aspiring for new hair growth will not have to depend on the impractical solution like oil, shampoos and even sprays and will have an actual treatment available for hair loss. The birth of a new baby brings happiness in the family as well as it also brings new responsibilities for the parents. In recent years, umbilical cords have become very important, as it has been revealed that they are a rich source of stem cells. According to CELS (2007), MSC can “differentiate into connective tissue cells such as bone, muscle, fat and tendon, gives them great potential in tissue engineering. This recommends a degree of uncertainty over the usage of MSC and therefore the importance of storing it in cord blood.
HSC are more immediately useful and there have been over 20,000 cord blood transplants treatments done. To collect cord blood, the method most commonly used is much like the procedure done when blood is donated. An estimated eighty types of diseases can be cured with the help of the stem cells in cord blood.
A lot of people are now considering various cord blood banks for storing their newborn’s cord blood because of cord blood’s extremely vital role in the treatment of failing and aging organ systems. Current treatments for diabetes seek above all to be individualized and must be modified when the patient’s circumstances do not allow the risk of occurrence of hypoglycemia. This applies, for example, patients with short life expectancy or those with cardiac or cerebrovascular disease. To ensure the effectiveness of the treatment prescribed, it is essential to educate patient properly, in addition to diet and exercise, so that it can correctly identify the signs that require immediate medical attention and to promote proper foot care. So far, the prognosis of patients with diabetes mellitus remains under the control of blood sugar through diet or drug therapy or insulin replacement.
However, there are some glimmers of hope, positive results from the transplantation of islets of Langerhans in diabetic patients has increased interest in use of cells capable of producing insulin. In experimental animal series has been able to differentiate from embryonic stem cells, insulin-secreting cells. But unfortunately not everything is said in the differentiation of stem cells for diabetes.
Research into this field, requires one to analyse the priorities of medical research alongside the prosperous future it could provide. They are unique in that they are unspecialized and thus retain the ability to develop into any of the wide spectrum of cells possible (in theory) within the human body (pluripotency). They are rare undifferentiated cells that can be found in differentiated tissues with a capacity for self renewal in addition to differentiation, although this ability is limited.
The number of cell types that they can develop into are restricted which hinders its versatility and its application to cure a variety of diseases. Having said the above, adult stem cells have a superiority in that the cells are the patient’s own cells, and there is no chance of their body rejecting the cells as they are compatible. The points that have been made as of yet, are to provide a basic knowledge and all will be explained further within the article alongside a more detailed analysis of the points made. However in reality, the human body is a complex being and there are an enormous number of complications to overcome e.g. In the United States of America, researchers used embryonic stem cells to cure mice who were bred to suffer from a Parkinson’s-like condition. Both control body chemistry using similar hormones, both have nervous systems that work in the same way, both react similarly to infection and injury.
Even the latest breakthrough by Geron Corporation, the first group to ever obtain the approval of the FDA to conduct clinical trials, has been delayed. Dr McKay and his colleagues began with embryonic stem cells and let them form an aggregate of cells containing all three embryonic germ layers (known as embryoid bodies).
Dr Melton, Nissim Benvinisty of the Hebrew University in Jerusalem, and Josef Itskovitz-Eldor of the Technion in Haifa, Israel, reported that human embryonic stem cells could be manipulated in culture to express the PDX-1 gene; a gene that controls insulin transcription.
The researchers found that when they injected these human cells into diabetic mice, the treatment alleviated diabetes in the rodents.
There are several complications to overcome before this becomes a working and viable solution.
After all, those with baldness cannot think anything beyond hair regrowth therefore, such advertisement gain so much popularity.


So, one can expect that if somehow the damaged hair cells could be replaced with stem cell it would bring wonders. In support of stem cell research, many groups have pointed to this as a ready source of stem cells that do not need aborted fetuses.
It is the blood that remains in the umbilical cord and placenta following birth and after the cutting cord. But, according to CELS (2007), “The small volume of cord blood (typically 75-100ml) means that the number of HSCs is low and the use of cord blood HSC is therefore limited to children under 40kg. In response to the potential for cord blood transplants to treat diseases of the blood and immune systems, both the private cord blood bank and the public one have developed since the mid to late 1990s. A technician utilizes a needle to withdraw the blood from the cord, and it is then stored in a blood bag. The incidence of diabetes mellitus is increasing to epidemic figures are seen all over the world. Hypoglycemia is a plasma glucose level that is abnormally low leading to symptoms of sympathetic nervous system stimulation or central nervous system dysfunction. The diet to achieve weight reduction is of great importance in overweight patients with type II diabetes mellitus. At each visit you make to your doctor, looking for signs or symptoms of complications, examine the peripheral pulses, sensation in the feet and legs, and probably perform a test of albuminoidal.
When patient characteristics make the use of insulin, is often preferred because human insulin is less antigenic varieties derived from animals. The low number of islet cells in patients, coupled with the inability to multiply these cells in vitro, has led to consider the possibility of using stem cells with capacity to differentiate into insulin-producing cells. When these stemcells are implanted into the spleens of mice, with induced diabetes can induce a normalization of glucose levels. In these techniques, as well as insulin-producing cells are generated in other cell types differ. The lack of tissue specific structures enables stem cells to form specialised cells in a process known as differentiation.
Other types of stem cells, such as Adult stem cells, are limited to what type of cells they can form and this has resulted in their use being very limited.
In rare circumstances, it has been caused by inflammation of the pancreas but this cause has only affected a miniscule proportion of sufferers. At present, the current treatment to ensure a patient stays healthy, is for them to take insulin injections 2-4 times a day for the rest of their lives. There is a tiny amount of somatic stem cells within each tissue and upon these being removed, their capacity to divide and multiply dwindles leading to difficulty in obtaining large amounts of somatic stem cells.
Somatic cells also have an increased chance of carrying mutations of the DNA compared to its human embryonic stem cell counterpart.
There is no need for immune suppressing drugs which would otherwise occur with embryonic stem cells making the patient vulnerable to other diseases. In the experiments, researchers cultured human embryonic stem cells and allowed them to spontaneously form embryoid bodies.
The new technique used will provide doctors with a bulk supply of clean, uncontaminated insulin-secreting cells for use in diabetes patients. As far as embryonic stem cell research is considered, we have come to a stage where what was one of the biggest concerns, the production of tumours, no longer occurs (in most cases) immediately after the transplant of the embryonic differentiated islet cells is completed. No, matter which oil, shampoo or herbal medicine they advocate the results are still not satisfactory. It has been noticed that those suffering from hair loss possess abnormal hair follicles that remains in the rest period for longer period of time thus hindering the regrowth stage. Parents are frequently turning to freezing their child’s umbilical cord blood stem cells, so they can use them later in life. Regenerative medicine incorporates the replacement or repair of a damaged organ which has been damaged because of aging, disease or some other congenital problems. Latest research proves that it can also be used to cure diseases such as; different types of cancers, metabolic disorders, blood disorders including thalassemia, bone marrow failure syndromes for example aplastic anemia and other immune system deficiencies.
Also, the studies have also shown positive effect on cardiovascular injuries and in the treatment of brain injury.
Actually, it is estimated that around one in every three Americans can benefit from regenerative medicine. Failure to achieve an improvement of hyperglycemia by diet then you must initiate a treatment with oral drugs and evaluate the patient. Periodic evaluation laboratory includes a lipid profile, serum creatinine levels, ECG and a complete ophthalmologic evaluation yearly.
However, most patients on insulin therapy, including those on human insulin preparations, there are measurable levels of antibodies to insulin, usually very low, but may have consequences in time as resistance to of insulin. Using stem cells for diabetes is seen as a much more viable and completely eliminate the problems of immune rejection. In addition, other stem cells research suggests that cells obtained from various sources such as pancreatic ducts, islets of Langerhans cells or bone marrows are able to produce insulin-secreting cells.
This mechanism, which is of vital importance at the time of its use in individuals, has not been controlled safely. The reason being the adult cells could have mutated over the respective person’s lifetime in a cell division process known as mitosis. They were then transplanted into a rat with Parkinson’s disease (PD), and the isolated cells formed functional connections and reduced disease symptoms.
Nonetheless, there is no guarantee that it will work on humans and it would be naive to believe it would be directly transferable to humans from rats without flaw. Using a sophisticated five-stage culturing technique, the researchers were able to induce the cells to form islet-like clusters that resembled those found in native pancreatic islets.
The embryoid bodies were then treated with various growth factors, including nerve growth factor.
It is a controlled process where the quality of the cell being implanted remains the same every time an implant is done. The researchers identified that the stem cells, which are located in the hair follicle bulge, could result into hair growth.
The importance of cord blood is new breakthrough in medical science and many people are unaware about this. Placenta prevents many harmful substances from entering and it acts as a store of energy and blood transfer for the developing embryo or fetus. Umbilical cord blood of your baby is a valuable source of stem cells and these stem cells are genetically unique to your baby and family.


After the collection of cord blood, it is and stored in a public or private cord blood bank in case of future need.
The other members of the family can also get benefits of cord blood storage, as organ transplants by close relatives tend to be more successful compared to unrelated donor transplants. In contrast, type II diabetes mellitus is usually diagnosed in asymptomatic patients during a routine medical examination or so later when the patient has clinical manifestations of a late complication, so it is recommended to make periodic checks on people who have a family history of this disease. Since diabetics are at increased risk of acute renal failure, radiological examinations requiring intravenous injection media contrast should be undertaken only if absolutely necessary and only if the patient is well hydrated. If research is successful on stem cells, the duo diabetes and stem cells would mark an unprecedented revolution in scientific research. Neither has been able to reproduce large quantities of insulin-producing cells, which would translate into higher costs for patients and clear therapeutic limitations.
There are numerous serious problems associated with diabetes if not treated ranging from Atheroma to Blindness. Embryonic stem cells have had less exposure to this process and thus regenerate at a pace that is much greater than that of adult stem cells. The researchers found that the grafted cells established functional connections with surrounding brain cells and began to release dopamine.
Until, an organisation has perfected testing on animals, it is only sensible to postpone the testing of humans, but the results are promising. The cells responded to normal glucose concentrations by secreting insulin, although insulin amounts were lower than those secreted by normal islet cells. PDX-1 is associated with the formation of beta islet cells and thus these results suggest that beta islet cells may be one of the cell types that spontaneously differentiate in the embryoid bodies.
Unfortunately, much of the science behind this new method remains behind closed doors and is difficult to access but a Dr Curt Freed, director of Neurotransplantation from the University of Colorado School of medicine was quoted saying “This is an extraordinary breakthrough by scientists at Novocell, this discovery holds promise for everyone with insulin-requiring diabetes. Cord blood is the blood found inside the placenta and the umbilical cord after the birth of a baby.
The blood that passed to fetus through placenta is highly charged with oxygen to keep the fetus alive and well without a direct air source. For personal use, the cost to collect and store this blood in a private bank is typically rather expensive and it is about $2,000 US Dollars (USD) for collection and $125 USD annually to store it privately. Regenerative medicine also permits the scientists to grow artificial organs in the laboratory and then place them inside the body of the patient. Nowadays, you will be able to find several cord blood banks, which offer easy cord blood collection options to you. We must await the results of further studies to verify whether the interaction of diabetes and stem cells could be the beginning of a new era of treatment for chronic diseases.
In the UK alone, 1 in 250 develops type one diabetes but it can increase to 15 in 250 if a first degree relative has been diagnosed with it. The rats that received the differentiated cells showed significant improvements in symptoms during behavioural tests. With most if not all medication being first tested on animals, it shows that results from animal testing are relevant and valid to use in relation to embryonic stem cells potential human use as has been the practice for several decades now in pharmaceuticals and medicine.
Quoted by Dr McKay “This system is unique in that the embryonic cells form a functioning pancreatic islet, complete with all the major cell types.
Researchers now think that nerve growth factor may be one of the key signals for inducing the differentiation of beta islet cells and can be exploited to direct differentiation in the laboratory. While outcomes of clinical trials are unpredictable, these cells are likely to be tested in patients soon. Cold blood is an extremely important component in stem cell research as cord blood stem cells are used for treatment of many diseases. After the birth of baby, the umbilical cord is severed and either removed or falls off, leaving a small scar which is properly known as the umbilicus. In the stem cell therapy, a person’s own stem cells are a very important part as their own stem cells can be absorbed back into their bodies without the risk of rejection. For patients who need organ replacement and are unable to find one due to acute shortage of organ donors, this treatment can be prove very beneficial. Since undifferentiated embryonic stem cells sometimes multiply out of control and form tumours, the researchers measured the number of cells in the grafts at several time points after the transplants. It would be reasonable to conclude that embryonic stem cells do in fact have the potential to cure diseases, but maybe not in the immediate future.
The cells assemble into islet-like structures that contain another layer, which contains neurons and is similar to intact islets from the pancreas. Therefore that leads to a scenario where immunosuppressive drugs must be taken in order for the immune system to not destroy the new cells. The blood is collected from the umbilical cord mainly for the presence of stem cells and other hematopoietic cells, which are vital for the treatment of blood and other genetic disorders. Also, they have a higher chance of matching family members than stem cells from bone marrow. Cord blood banking is very important for regenerative medicine because it contains stem cells, which can be used to treat diseases for example; brain injury, diabetes and in the treatment of cardiovascular problems. The number of cells in the grafted areas stabilized by four weeks after the transplants, and none of the rats developed tumours. A more thorough conclusion can only be made with some evidence of human testing but with none being conducted; only time will give a concrete conclusion but at present, the results are looking highly promising. With the backing of a neutral head researcher of another organisation, Dr Freed, also meriting Novocell on their discovery alongside ABC News Medical unit, it is a huge advancement in the race to find a cure. That in turn leads to a very dangerous situation where the respective person is left with a very vulnerable body where they are susceptible to a variety of diseases. Although the levels of insulin produced were not the same as that of healthy islet cells, it is significant progress and with some alterations and tweaking, the future is looking hopeful to cure diabetes type one, albeit in mice. Another key factor to consider is for what period of time will the cells remain fully differentiated?
That said, a cure in mice and rats is often not far from that of humans as explained in paragraph three and four on page four. If this is not answered, then the potential for cells to become carcinogenic and for tumours to form is always a risk.



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