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Several therapeutic modalities, including grid laser photocoagulation, [1] vitrectomy, [2] intravitreal injection of ranibizumab, [3] or triamcinolone acetonide [4] have been investigated. Vitrectomy for diabetic macular traction and edema associated with posterior hyaloidal traction. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study): A 12-month, randomized, controlled, double-masked, multicenter phase II study.
Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. The predictive value of patient and eye characteristics on the course of subclinical diabetic macular edema.
Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy. Correlation of visual acuity and macular thickness measured by optical coherence tomography in patients with persistent macular edema.

The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema. The efficacies of these therapies have been evaluated by best-corrected visual acuity (BCVA) and macular thickness measurement using optical coherence tomography (OCT). Association of the extent of diabetic macular edema as assessed by optical coherence tomography with visual acuity and retinal outcome variables. Association of outer retinal layer morphology with visual acuity in patients with retinal vein occlusion: SCORE Study Report 13. A correlation between BCVA and the OCT-measured macular thickness has been reported but its significance was variable.
Several articles have described association between the integrity of the foveal photoreceptor layer and the BCVA in macular diseases. Patients were recruited from the outpatient clinic of Kasr El-Aini Hospital - Cairo University in the period from June 2011 to January 2012. This study included diabetic patients with clinically significant DME diagnosed by slit-lamp biomicroscopy, defined according to the ETDRS.

We measured the central subfield foveal thickness, defined as the average retinal thickness (RT) of 1-mm central scanned area, using macular map (MM5) that is 5 × 5 mm square grid centered on fixation. OCT was done to all patients before treatment, at 1 and 6 months of treatment.Statistical analysisData management and analysis were performed using Statistical Analysis Systems. Comparisons between the two groups with respect to numeric variables were done by Mann-Whitney test, a nonparametric test equivalent to the Student's t test.
Kruskal-Wallis test followed by the post hoc Dunn test for nonparametric data was performed to compare more than two groups with respect to numeric variables. The chi-square test was used to compare between the groups with respect to categorical data.
The Spearman correlation for nonparametric data was used (Dawson and Trapp, 2001) to assess the degree of association between the numeric variables All P-values are two-sided.

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