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Statin as we know is a component used in drugs that help to reduce the blood level of cholesterol in order to reduce the risk of diabetes and heart attack.
On January 31, 2014 FDA updated their report about the use of drugs containing Statins advising millions of Americans who use Statins based drugs as well as health professionals to take caution. Among the warnings are those that are related to damages to the liver, memory loss and a host of other side effects. If you take careful note you will know that all those drugs that are based on Statins are synthetic drugs and there is nothing natural in them.
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If you happen to be using any drugs containing Statins, we advise you to consult your doctor ASAP.
Jaideep Patel,Seth S Martin,Maciej Banach Expert Opinion on Pharmacotherapy. Soumya Patnaik,Amar Narayan Patnaik Journal of Indian College of Cardiology. Those who have a financial interest in the outcome manipulate the results, Major study finds that all 37 journal articles positive effects over stated; the average was 32%. Biaxin is a medical preparation that is referred to the drug family of macrolide antibiotics. People with advanced AIDS forms also choose to use this medication for preventing serious bacterial infections. This medical preparation is commonly produced by Abbot Laboratories and is referred to the class of medications known as macrolides. The main component of Biaxin - Clarithromycin - can be easily recognized - it is a crystalline powder of white color, soluble in acetone, partly soluble in acetonitrile, methanol and ethanol and insoluble in water.
You can buy Biaxin in different forms: as IR tabs (instant-release), ER pills (extended-release) and as granules for oral suspension (taken as a liquid). Every oval film-coated IR pill of yellow color printed with BIAXIN has at least 250 mg (up to 500 mg) of Clarithromycin and other non-active components. Clarithromycin as a major component of Biaxin stands for an antibiotic that is applied for curing a wide range of bacterial infections. This medicine was also tested and allowed for curing these enumerated infections only on the terms they were triggered by certain types of bacteria. In addition, it is significant to point out that Clarithromycin turns to be inefficient when it comes to treatment of viral infections like flu or cold. Trust your healthcare provider if he asks you to go through certain tests before starting to take Biaxin tabs.
Please, consider the fact, manufacturers advise to prevent giving this drug to infants younger than 6 months. In certain cases you therapist may recommend using this drug for treating some infections not mentioned in the list of FDA-approved indications for Clarithromycin. There are many situations when Clarithromycin (Biaxin) can be recommended as monotherapy and as a part of a combinatory treatment and that is why there is no a standard dosage for this medication. Not under any circumstances, you are to change dosage unless your doctor recommends adjusting it.
Also keep in mind that you have to finish prescription even if you feel better than before using Biaxin. Patients who were diagnosed with severe kidney insufficiency or a kidney disease have to tell their therapists about this in order to lower the dose of Clarithromycin. The dosage rules on different forms of Biaxin - IR, XR, XL pills or oral suspension - are different.
It is up to you whether to use pills or liquid suspension on an empty stomach or with meals.
If you have any doubts or concerns how to use these pills for treating an infection, please consult a therapist. In order to provide the best conditions for efficient treatment with Biaxin you need to remember about precautions and warning referred to this medication. For instance, people who suffer from liver or kidney disorder or who are using some strong medication may require special treatment when it comes to this medication.
In addition, inform your therapist if you are currently breast-feeding, pregnant or have plans to become pregnant any time soon. Also discuss with your doctor all medications, vitamins, suspensions and supplements even herbal ones you are currently taking or was taking during some time not long time ago.
If during or after using Biaxin you started to experience bloody or watery diarrhea, immediately appeal to a therapist. Avoid overdosing and overusing of Biaxin pills since in such way you increase the risk for the development of antibiotic-resistant bacteria. During administration of Biaxin you may develop yeast infections (certain mouth or vaginal infections) that can be a reaction to the use of this preparation.
Please do not skip prescribed doses and do not cease taking this drug sooner than was recommended.
Biaxin cannot be applied during pregnancy or lactation since FDA pregnancy rated this medical preparation with category C. Interaction of Biaxin with certain medical preparations may also lead to negative reactions and decreased efficiency. Immediately call an ambulance or appeal to a doctor if you have noticed the sings of an allergic reaction to Clarithromycin.
Bear in mind that there are possible other adverse reactions this medical preparation may trigger. The prevention of bacterial growth and multiplication is the main effect provided by Clarithromycin that can interfere with the bacterial synthesis.
The researchers working for the Japanese company Taisho Pharmaceutical invented Clarithromycin in the 70's.
As it has mentioned earlier, Biaxin is a trademark medication based on Clarithromycin that is produced by Abbot Laboratories. All 1000 mg ER tabs of generic Clarithromycin do not technically belong to generic versions of Biaxin XL pills since initially Biaxin XL medicine wasn't offered in such strength. All generic versions of popular brand medication pass through a row of tests in order to compare their efficiency with their brand forerunners.
Biaxin is a medication with the active ingredient clarithromycin in its composition, used to treat ent and skin infections.
When the two types of medications are taken together, the levels of benzodiazepines may increase, causing excessive drowsiness, that's why it's important to coordinate the dosage of the mentioned drugs with your healthcare professional. First of all, you must avoid the combination of Biaxin with such statins as lovastatin or simvastatin. Digoxin is a medication, supporting the heart contractions with an active ingredient of natural origin. Carbamazepine isn't processed properly in the patient's organism when the two medications are taken together. Though being a natural product for the treatment of gout, this remedy is highly toxic, and Biaxin can increase its toxicity, which is generally dangerous and can be fatal, especially for the patients with the impaired kidney or liver function. When the two drugs are administered at the same time, their dosage must be regulated by a physician.
The combination of Biaxin with these migraine-treating medications belong to the moderate degree of interaction. Theophylline intreaction with Biaxin may increase serum theophylline concentrations in blood if these medications are combined.
Combining Biaxin with Warfarin may cause bleeding, that's why the dosage and the possibility to take them together must be coordinated with your doctor.
Anti-cholesterol drugs known as statins may help impotent men have stronger erections, a new evidence review suggests. But typical effects appear to be much smaller than those caused by Viagra-like drugs, and it may be barely noticeable to many men, an expert said. Statins, which include well-known medications such as Lipitor and Zocor, are immensely popular in the United States.
However, statins appeared to improve erections by only about a third or half as much as previously reported for impotency drugs like Viagra. If you happen to be on statin drug therapy for a supposed heart attack risk and have suffered acute pancreatitis you may want to re-think why you are on those drugs to begin with since cholesterol may not be THE major player in atherosclerotic heart disease.
Like all synthetic creations that come out of big pharma labratories statin drugs cause unwated side effect, some of which can be deadly.
The above side effects from Crestor were reported by actual users and can be verified here.
If you are on statin therapy for high blood fat levels to decrease you risk of recurrent acute pancreatitis you should consider supplementing CoQ10 because eating a boat load of salmon each week may not be the smart answer due to the high fat content of salmon.



The good news about plant sterols is that they do seem to lower cholesterol like statin drugs and they also fight inflammation [11],[12].
In March 2012, Scripps Research Institute cardiologist Eric Topol wrote an op-ed for The New York Times, arguing that statin medications (such as Lipitor, Crestor, and Zocor) should be avoided due to the increased risk of diabetes.
The Journal of Diabetes study analyzed the medical histories of patients in the United States who were over 39 years old and had been diagnosed with peripheral neuropathy (PN). Needless to say, patients who have suffered from the deleterious consequences of prescription medication are unlikely to want to treat PN with additional medication. A drug that can help to bring down the effects of factors that lead to impotence is now a potential cause on itself. Statins cause significant reductions in LH-stimulated testosterone production by rat Leydig cells; possible human relevance.
Statin induced inhibition in testosterone production was bypassed by providing pregnenolone or progesterone. Bypassing the site of action with pregnenolone resulted in greater LH stimulated testosterone production than progesterone. LH responsiveness of Leydig cells was only maintained when progesterone was used to bypass the site of action. The good news however is that the effects are reversible as soon as the patient stops taking the drugs.
The inclusion of Bioperine helps easier and faster absorption of the natural ingredients for quicker effects. Though they have confirmed safety and efficacy profile, statins have reportedly been associated with several adverse effects forcing abrupt discontinuation without consulting their physician. Discontinuation of lipid modifying drugs among commercially insured United States patients in recent clinical practice. Diagnosis, prevention, and management of statin adverse effects and intolerance: Proceedings of a canadian working group consensus conference. Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients.
Monday, wednesday and friday dosing of rosuvastatin in patients intolerant to statin therapy.
Efficacy of rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins. Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).
Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.
Treatment of statin adverse effects with supplementation of Coenzyme Q 10 and statin drug discontinuation. This medication is a trademark for Clarithromycin that was invented for fighting bacteria in a patient's body. Biaxin is also recommended when there is need to decrease bacteria's functions to produce protein, in such way this drug stops bacteria's growth. This medication is based on Clarithromycin that can bind to bacterial ribosomes and interfere with their production of proteins responsible for bacterial multiplication and growth. It is offered as a trademark Biaxin in suspensions (liquid for oral intakes) and short-acting pills. These tests may show if certain bacteria in your body causing infection are resistant or not to Clarithromycin treatment.
Cessation of Biaxin until the end of prescription may lead to the repetitive development of antibiotic resistant bacteria. IR and XR tabs as well as oral suspension are to be applied at least twice per day (sometimes thrice per day). These warnings are also referred to people with some food or drug allergies and for pregnant or breast-feeding women. This risk may increase especially if a person already has this defect, the certain type of arrhythmia or simultaneously takes any medications that can cause this defect as well. If you feel unwell go to a healthcare provider and he will prescribe the necessary amount of Clarithromycin for treating certain bacterial infection. Discuss with your healthcare provider Biaxin use if you are currently breast-feeding or going to become pregnant soon. Or if you had before an allergy reaction to any other macrolide antibiotics as Ery-Tabs (Erythromycin). These symptoms are difficulties in breathing, hives, facial swelling (lips, mouth, throat or tongue). This drug can bind to 50S subunit of ribosomes in bacteria and in such way, it provides the inhibition of peptides' translation. They were trying to make an analogue of the popular macrolide antibiotic Erythromycin without its known side effects like upset stomach, nausea and stomach pain.
Since all patents of brand Biaxin have already expired there is legally available generic version of Clarithromycin.
If you intend to take Biaxin, you need to pay close attention to its possible interaction with other drugs, which may increase the possibility of side effects and cause serious health problems. Generally, when Biaxin is taken with statins, their level in blood rises and so do the risks of side effects. When taking together, the drugs may lead towards harmful effects: Digoxin action may provoke too slow or irregular heartbeat. If blood levels of carbamazepine rise, that's fraught with a toxic effect, potentially manifested in such symptoms as dizziness, drowsiness, or loss of coordination.
In this case usually the dosage of PDE5 inhibitor is decreased or its usage is postponed until a patient finishes the course of Biaxin. That means you may take this combination but you need to consult with your physician about it first. The combination of the two drugs may be potentially dangerous as their effect increases, as well as the possibility of risk factors.
Many people fail to consistently take the cholesterol-lowering medications, which can cause side effects such as joint pain.
John Kostis, director of the Cardiovascular Institute of New Jersey at Rutgers University’s Robert Wood Johnson Medical School.
Statin therapy, when one has severely high lipids, seems to actually be a good thing in this case.
In fact, Lipitor, before it went off patent, averaged over 5 BILLION PROFIT (not gross revenue, profit!) each year. Since CoQ10 is found in every cell of the body with the largest amounts found in the heart (it strengthens the heart wall muscle so it pumps good and strong) this could be the very reason some patients using statin drugs such as Crestor find themselves diagnosed with cardiomyopathy [10]. For those who suffer recurrent AP or now have CP high fat foods (no matter how good the fat) are not your friend. Like most natural plant source alternative remedies plant sterols or phytosterols do not seem to kill people with dangerous side effects. The fact that they can also lower inflammation may be an added benefit if they in fact lower pancreas inflammation.
IF you have been diagnosed with CP my whole blog is full of information (what I did, what I still do, etc to handle CP). Also in 2012, the Journal of Diabetes exposed the compelling connection between peripheral neuropathy and statin drugs. In fact, studies have linked this class of drugs with more than 300 adverse conditions (including memory loss), building a strong case that statins may do more harm than good for many patients.
By checking which of those patients had been prescribed statins, researchers were able to determine if the risk of neuropathy pain was higher for the statin population. Healthcare education resource GreenMedInfo has compiled a collection of hundreds of side-effects from clinical studies and other medical literature. Although the research and tests were carried out on rats yet the scientists claim there is an indication that it can affect humans too.
This medication is commonly applied for curing multiple types of various bacterial infections that may affect skin and respiratory system of a human.
As it was mentioned, Clarithromycin is widely applied for treatment of bacterial infections.
Diverse bacteria may have various resistant patterns to Biaxin in different regions of the same country.
To these non-approved uses of Biaxin are referred infections caused by bacteria susceptible to Clarithromycin. Only the type and severity of an infection in your case affect the length of your Biaxin treatment. If you need to use pills twice per day, make sure the intervals between doses at least last no less than 12 hours.


Clarithromycin is very close by mechanism of action to another macrolide Erythromycin but it turns out that it is more efficient in fighting with Gram-negative bacteria like Legionella pneumophila. In 1980 the company Taisho filed for patent protection for their new medication and started to release it on the Japanese pharmaceutical market under the trademark Clarith in 1991. Food and Drug Administration) checks thoroughly if generics can be called cheaper equivalents to brand medications they were derived from. Biaxin may slow down the process of the ergot breakdown by the liver and cause side effects.
When combined with another drug, the effect of either may be decreased, increased or changed. However, he cautioned that men with normal cholesterol levels shouldn’t take statins, and should rely on existing drugs for erectile dysfunction if needed. This is probably especially exciting for those who may be on statin drugs for genetically predisposed HIGH blood fat level condition that has been diagnosed as the cause of your problems. I know just enough about Hep C to be dangerous, very, very little about Interferon which I thought was used mainly for certain cancers.
The study linking the drugs with neuropathy pain is of particular interest to those with chronic pain who take prescription medication to manage cholesterol levels. A three-year analysis of statin users was outlined in a 2011 Neuro Endocrinology Letters article. According to the site, one of the primary dangers of statins is neurotoxicity – nerve damage that can eventually take the form of PN. Methods such as spinal manipulation, electro analgesia, and laser therapy are core strategies of our integrated plans. Statins were shown to adversely affect fatty acid oxidation, decrease sarcolemal cholesterol, deplete isoprenoid, disturb calcium homeostasis and lipid metabolism, cause autoimmune phenomena, increase intracellular lipids, and cause mitochondrial dysfunction due to inhibition of ubiquinone or coenzyme Q10 production, leading to emergence of statin-induced adverse effects [Table 1]. Phan Alternative and Complementary Therapies. If applied along with other preparations Biaxin can be used as treatment of stomach ulcers triggered by such bacteria as Helicobacter pylori. Some bacterial infections will demand using this drug only few days in a row while the others may require much longer oral administration. In addition to this beneficial bacteriostatic effect Clarithromycin can cope with the growth of such bacteria as Streptococcus pneumonia, Neisseria gonorrhoeae and Haemophilus influenza.
Since 1985 Taisho collaborates with Abbot Laboratories that produces this medication under brand name Biaxin. Be attentive, when considering any drug combinations with Biaxin and seek for qualfied medical recommendations before you start taking them. It is ALL risk vs benefit yet it some cases it seems your choices are a rock or a hard spot. How many companies can you name that have achieved “Billion dollar” status let alone make billions from just one product? Yet even though Crestor was taken off the market due to serious side effects [5] by the FDA obviously the formula was either changed or AstraZeneca greased the FDA’s palm with enough cash to look the other way because it was back on the market in short order [6],[7]. So in the case of those who have recurrent pancreatitis due to high blood fat levels one would need to do more research before subjecting themselves to another possible acute pancreatitis attack by switching to natural plant sterols that may not do an effective job if they are currently doing well on stain drugs. The study suggested that patients were suffering from underlying consequences of statins, even when symptoms were “clinically silent.” The authors of that study called the ill-effects of statins on a patient’s peripheral nerves “definite” when they are taken for more than 24 months. You could, for example, have read about this on my Swedish blog three years ago and in my Swedish book The Food rEvolution, 2011. Fatal incidence of rhabdomyolysis was considered as the major reason of cerivastatin withdrawal in 2001. But if you treat your normal cholesterol number with statins you risk getting diabetes for no good reason.
In addition, patients with muscle weakness or bilateral proximal muscle pain, excluding other known causes have also been recommended to have their CK assessed. Patients with CK level >10 times the ULN most likely suffer from myopathy and have brown discoloration of urine, which serves as an indicator of overall elevation of myoglobin in the blood.
These patients with myopathy have elevated levels of transaminases which normalise on improvement of myopathy.
I'd urge anyone with high cholesterol not to take them and to find out why it's high instead. Roberts has written a book called “The Truth About Statins” that was released in April last year. If ALT or AST levels are >3 times the ULN in an asymptomatic patient with other liver abnormalities, the liver function test should be done within a week and statins must be stopped temporarily if ALT level did not fall to the normal level.
Roberts is a cardiologist, associate clinical professor at the Alpert Medical School of Brown University as well as director of the Women?s Cardiac Center at the Miriam Hospital in Rhode Island. The panel did not recommend routine evaluation but suggested repetition of the test in case the transaminases are >3 times ULN and further evaluation if it remains elevated. Roberts discusses the benefits and health risks of statin therapy in a very professional way. She discusses the role of cholesterol in the body and explains the role of cardiovascular risk factors.
I recommend everyone interested in cardiovascular disease and modern-day health care to read Dr Roberts?s book. It is a strong reminder of our lack of knowledge of the long-term effects of drugs that are being prescribed to millions of people worldwide. Atorvastatin with a mean half-life of 14 hrs is metabolised into two active metabolites-orthohydroxy and parahydroxy forms. Both these active metabolites contribute to 70% activity of atorvastatin and have a half-life of 20 to 30 hrs. Two patients who developed intolerance to daily atorvastatin therapy, due to myalgia, were subsequently treated with rosuvastatin (at a dosage of 2.5 mg and 5 mg) on 1 st , 3 rd , and 5 th days of the week, respectively. At both the doses, the level of LDL-C decreased by 38% and 20%, respectively with the resolution of adverse effects after six weeks of treatment. In another study, eight patients who were intolerant to daily statin responded well with once-weekly dosage of rosuvastatin (5-20 mg) and reported a mean LDL-C reduction of 29%. First, alternate day statin dose administration causes a lower LDL-C reduction (up to 10-15% less) compared to daily dose regimen in high-risk patients. However, this LDL-C reduction was much lower than the ideal LDL-C target set for each high-risk patient. Thus alternate day dosing strategy should be used only as a secondary option in specific high-risk patients who are intolerant to lower statin dosage.Non statin lipid-lowering drugsNon-statin lipid lowering drugs include a bile acid sequestrant (colesevelam), an intestinal cholesterol absorption inhibitor (ezetimibe), fibrates, and niacin which may be either used alone or in combination.
Hannah Yoseph and James Yoseph.5Nan CMarch 15 2013 1For years, my previous primary care doctors have pushed statins on me because my cholesterol was borderline high.
Co-administration of ezetimibe and bile acid sequestrants (colesevelam, colestipol, or cholestyramine) yields additional reduction of LDL-C levels without any adverse effects in comparison to stable bile acid sequestrant regimen alone. Addition of ezetimibe to nicotinic acid lowers LDL-C levels without modifying nicotinic acid-induced increase of HDL-C. Functional food containing phytosterols or plant sterol containing tablets have been reported to reduce LDL-C levels up to 5-10% in patients taking a stable dose of a statin.
This combination of plant sterol and statins was have been reported as well tolerated and safe. The efficacy of these dietary interventions was further strengthened by addition of nutraceuticals such as red yeast. But due to its limitation of palatability, dietary supplements were used as an alternative option. Monascus yeast produces a family of substances called monacolins capable of inhibiting the enzyme HMG-CoA reductase and also contains unsaturated fatty acids and phytosterols. Red yeast rice offers only modest LDL-C lowering (up to 20%) and has been prescribed to only low-risk individuals or in whom LDL-C level is not far from the target.
Various studies have reported significant improvement in statin-induced adverse effects-myopathy, myalgia, peripheral neuropathy, fatigue, dyspnoea, and memory loss if coenzyme Q10 was given as a co-therapy with statins.
A recent trial has shown that 92% of patients become myalgia free after three months of vitamin D supplementation.
Furthermore, several studies have reported negative consequences of acute statin withdrawal on cardiac patients, especially the patients with ACS and stroke.
Increased understanding of statin-induced adverse-effects and awareness of clinical implications of acute statin withdrawal has discouraged patients from abrupt discontinuation of statin therapy. Statin intolerance has been effectively managed either by the use of alternate-day statin regimen with longer half lives like atorvastatin and rosuvastatin, combination of statins with non-statins, dietary interventions, or by specific pharmacotherapies.
This only lasted a few seconds,but it happened several other times out in the yard.Needless to say I've stopped statins against Dr's orders and refuse to take them again.



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