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Presentation on theme: "Health with usFIRST MEDICAL CENTER1 Practical Update on Hypertension Dr.
First Medical Center health with us1 An unusual cause of Hypertension Adrenal Glands Disorders Dr.
HYPERTENSION Detection, Evaluation and Non-pharmacologic Intervention Misbah Keen, MD, FAAFP Act. Identify differential diagnosis of a case presented with the symptoms of lower limb oedema. It is important for women to talk to their nurse or doctor about the health of their heart and blood vessels It is important for women to talk to their. Hypertension is one of the most important preventable causes of premature morbidity and mortality.
Your Institution Here Your Institution Here 2011 American Heart Association Guidelines for Cardiovascular Disease Prevention in Women: For Obstetrician-Gynecologists. SYSTEMIC HYPERTENSION Definitions of hypertension Elevated arterial blood pressure is a major cause of premature vascular disease leading to cerebrovascular. The Pharmacists Role in Treating Hypertension Thomas Owens, MD Saint Francis University CERMUSA. In English, Nigella sativa seed is variously called, among the most used names are black cumin and blackseed because of the dark colour of the seeds.
Most of the therapeutic properties of this plant are due to the presence of thymoquinone (TQ) which is the major bioactive component of the essential oil (30%-48%). TQ exhibited a significant bactericidal activity against various human pathogenic bacteria especially Gram positive cocci preventing cell adhesion to glass slides surface. Two novel antifungal defensins, named Ns-D1 and Ns-D2, were isolated from the seeds; their high antifungal activity makes them promising candidates for engineering pathogen-resistant plants.
Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. The results indicate that black seed might be a beneficial adjuvant to oral hypoglycemic agents in type 2 diabetic patients. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Moreover, studies showed that the extract of Nigella sativa significantly reduced plasma triglycerides while increasing HDL-cholesterol via a reduction in HMG-CoA reductase activity, and an increase in arylesterase activity. It has also been reported a strong analgesic effect through indirect activation of the superspinal ?1 and ? receptors. Some results indicate that the potent antioxidant effects of NSO reduce excitability and induction of seizures in epileptic animals and improve some of the adverse effects of antiepileptic drugs.
Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig.
The mechanism of the hepatoprotective action of thymoquinone is not certain, but may be related to the preservation of intracellular glutathione, inhibition of thromboxane B2 production and lipid peroxidation. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. TQ diminished nuclear translocation and DNA binding of nuclear factor-kappaB (NF-?B), attenuates the phosphorylation of Akt, c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase.
Together with its ability to induce the expression of cytoprotective proteins, this provides a mechanistic basis of anti-inflammatory and antioxidative effects of TQ. Oral administration resulted in significantly reduced levels of pro-inflammatory mediators [IL-1?, IL-6, TNF-?, IFN-? and PGE~2~], increase in IL-10, attenuate expression of cyclooxygenase-2 (preventing eicosanoid generation) and inhibits HDAC activity. These effects were tested on experimental autoimmune encephalomyelitis (EAE), an animal model that mimic human multiple sclerosis. Studies on myeloblastic leukemia shows that TQ -induced apoptosis is associated with upregulation of Bax, downregulation of Bcl2 proteins and activation of caspases 3, 9 and 8; these effect on Bcl2 is linked to and dependent on p53.
TQ also down-regulates the expression of NF-kappa B antiapoptotic gene products (IAP1, IAP2, XIAP Bcl-2, Bcl-xL, and survivin). Studies on APC- mice fed with TQ have obtained the following results: decreased number of large polyps in small intestine and induced apoptosis in neoplastic tissue but not in normal mucosa. Researchers found that TQ inhibits DNA synthesis, proliferation, and viability of cancerous prostate epithelial cells by down-regulating AR (androgen receptor) and E2F-1 (a transcription factor ); it prevents tumor angiogenesis in xenograft human prostate cancer (PC3) models, and inhibits human prostate tumor growth at low dosage with almost no chemotoxic side effects.
TQ also inhibits VEGF-induced extracellular signal-regulated kinase activation but showed no inhibitory effects on VEGFR2 activation. Other studies inquired the anticancer effects of TQ on breast cancer cells, and its potential effect on the PPAR-? activation pathway .



Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-? pathway. The effects of thymoquinone on human gene expression has been investigated using DNA microarray technology: analysis revealed a downregulated expression of CYP1A1 and UGT1A8 (by 43- and 11fold, respectively), genes involved in the estrogen metabolic pathway. Finally, other studies revealed a mitochondrial dysfunction in TQ treated cells, by examining the phosphorylation status of PDK1, PTEN, Akt, c-raf, GSK-3? and Bad.
Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. The inhibition of migration of melanoma cells by thymoquinone was accompanied by a decreased expression of NLRP3 (constitutively activated in tumor cells) , partly due to ROS reduction, which resulted in inactivation of caspase-1 and in the consequent secretion of IL-1? and IL-18.
Using cervical squamous carcinoma cells the citotoxicity of TQ was compared to cisplatin: TQ was found more ciytotoxic towards tumor cells, but the toxicity was less towards the normal cells. Failure to reach goal BP in patients who are adhering to full doses of an appropriate three drug regimen that includes a diuretic Note: This is very common and less tried by clinicians and paramedics.
Essmat Gemeay Outline: Interdiction Definition Causes Complication Risk facture Sings and symptoms Diagnostic study management Nursing.
Hypertension, or high blood pressure, is a common condition that will catch up with most people who live into older age.
Kauser Usman (MD) Associate Professor Department of Medicine King George’s Medical University, Lucknow. 2 Leading Risks For Death (World Health Organization 2002) 3 5 4 2 1 Cholesterol Alcohol HYPERTENSION Tobacco use Overweight. WHAT IS BLOOD PRESSURE C o n t e n t s [ h i d e ] 1 M e a s u r e m e n t 1 M e a s u r e m e n t 1.
HUSSEIN SAAD (MRCP) ASSISTANT PROFESSOR CONSULTANT FAMILY MEDICINE COLLEGE OF MEDICINE KING SAUD UNIVERSITY MANAGEMENT OF HYPERTENSION. 2 3 Review Of Management Of Hypertension By Professor Dr Intekhab Alam Department of Medicine Lady Reading Hospital, Peshawar.
The compounds also blocked the production of highly atherogenic sd-LDL thus reducing cardiovascular risk. Besides the antioxidant property, TQ inhibits proton pump, pepsin secretion and neutrophil infiltration, while enhancing mucin secretion, prostaglandine activity and nitric oxide production. TQ was found to be almost 90% preventive and 50% curative in chronic relapsing EAE due to its antioxidant and immunomodulating effects. First of all, studies found that TQ suppressed TNF-induced NF-kappa B activation in a dose- and time-dependent manner. It was found that, apart from the activation of caspases 8, 9 and 7 and the downregulation of Bcl-2, Bcl-xL and survivin , TQ reduces migration and invasive properties of cancer cells. After 24h incubation with TQ, cells showed a G1 phase arrest and then the shift to subG1 phase, indicating apoptosis, supported by suppression of cyclin D1, cyclin E and cyclin dependent kinase inhibitor p27 expression. Thus, the results indicate that thymoquinone can be a potential immunotherapeutic agent not only as an adjuvant therapy for melanoma, but also, in the control and prevention of metastatic melanoma.
The flowers are delicate, and usually coloured pale blue and white, with five to ten petals. This was related to its ability of inducing an oxidative stress which could in turn render the parasite vulnerable to damage by the host.
The hypoglycemic effect observed were due to amelioration of ?-cell ultrastructure through decreased oxidative stress, increased insulin secretion and reduced sodium-dependent glucose transport across jejunum. Part of these effetcs is mediated centrally via direct and indirect interaction with tryptaminergic and cholinergic systems. This significantly improved asma symptoms severity and frequency, together with PFT values. This is correlated with sequential inhibition of IKK (IkB kinase), IkB phosphorylation and degradation, p65 nuclear translocation. Interestingly, TQ was found to increase PPAR-? activity: this increase was prevented in presence of PPAR-? specific inhibitor and PPAR-? dominant negative plasmid, suggesting that TQ may act as a ligand of PPAR-?. There is a posibility that Nigella may interact with other co-administrated drugs, modulating their pharmacological effect.
The fruit is a large and inflated capsule composed of three to seven united follicles, each containing numerous seeds. Main pressure reduction was 22%, compared with that of the calcium channel blocker nifedipine which caused an 18% decrease in arterial blood pressure.



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