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Each kidney contains around a million units called nephrons, each of which is a microscopic filter for blood. Pyelonephritis (infection of kidney pelvis): Bacteria may infect the kidney, usually causing back pain and fever. Glomerulonephritis: An overactive immune system may attack the kidney, causing inflammation and some damage.
Kidney stones (nephrolithiasis): Minerals in urine form crystals (stones), which may grow large enough to block urine flow. Nephrotic syndrome: Damage to the kidneys causes them to spill large amounts of protein into the urine.
Polycystic kidney disease: A genetic condition resulting in large cysts in both kidneys that impair their function. End stage renal disease (ESRD): Complete loss of kidney function, usually due to progressive chronic kidney disease. Papillary necrosis: Severe damage to the kidneys can cause chunks of kidney tissue to break off internally and clog the kidneys.

Diabetic nephropathy: High blood sugar from diabetes progressively damages the kidneys, eventually causing chronic kidney disease. Interstitial nephritis: Inflammation of the connective tissue inside the kidney, often causing acute renal failure.
Minimal change disease: A form of nephrotic syndrome in which kidney cells look almost normal under the microscope. Nephrogenic diabetes insipidus: The kidneys lose the ability to concentrate the urine, usually due to a drug reaction. The tracer dose divided by Cp at time zero provides us with the intravascular plasma volume.
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It's possible to lose as much as 90% of kidney function without experiencing any symptoms or problems. A spread of bacteria from an untreated bladder infection is the most common cause of pyelonephritis.

Dehydration, a blockage in the urinary tract, or kidney damage can cause acute renal failure, which may be reversible. Although it's rarely dangerous, diabetes insipidus causes constant thirst and frequent urination. The kidneys remove wastes, control the body's fluid balance, and regulate the balance of electrolytes.
As the kidneys filter blood, they create urine, which collects in the kidneys' pelvis -- funnel-shaped structures that drain down tubes called ureters to the bladder.

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