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Androgen deficiency or hypogonadism is the most common opioid induced endocrinopathy seen in long-term opioid treatment. Opioid syndrome is characterized as low levels of gonadotropins in male and female patients.
One of the side effects of opioid is low testosterone level in male.2 Researches suggests long acting opioids more often causes opioid induced hypogonadism.
Low testosterone level is more often seen in long acting opioids than short acting opioids.
Erectile dysfunction in male and infertility in female is less common when short acting opioids are taken for short period of time.
The study published in the Journal of Pain by Daniel H.W in the year 2006 suggests testosterone patch was effective in treating opioid induced testosterone deficiency.
Opioid induced androgen deficiency syndrome (OPIAD Syndrome) is diagnosed after multiple blood biochemical studies and treatment is androgen replacement therapy. Testosterone is available as topical, oral buccal absorption pills and as a liquid for injection. Opioid analgesics suppress male gonadal function but opioid use in males and females does not correlate with symptoms of sexual dysfunction. Opioid endocrinopathy in women consuming prescribed sustained-action opioids for control of nonmalignant pain. Department of Family Practice, University of California Davis Medical School, Redding, California, USA. Open-label pilot study of testosterone patch therapy in men with opioid-induced androgen deficiency. Men who regularly take pain relievers such as ibuprofen and aspirin may be at increased risk for erectile dysfunction, new research suggests. Men who use non-steroidal anti-inflammatory drugs (NSAIDs) three times a day for more than three months are at a 22% increased risk of erectile dysfunction, reports Steve Jacobsen, director of research for Kaiser Permanente Southern California, in this week’s Journal of Urology.



More than 30 million people a day take these prescription and over-the-counter pain relievers. The observational study, which began in 2002, included 80,966 men ages 45 to 69 who were members of Kaiser managed care plans in California. A previous smaller study suggested a similar link, but Jacobsen says it’s too early to conclude that ibuprofen is the reason for erectile dysfunction. The results raise more questions than they answer, says Stephen Kraus, professor and vice chairman of urology at the University of Texas Health Science Center at San Antonio. He says NSAIDs have been shown to reduce risk of heart disease, so the same should be true of erectile dysfunction, which can be linked to circulation problems. The study authors suggest several theories, including that while treating someone to improve blood flow may potentially make erections better, it could also hinder other pathways involved in healthy erectile function.
Psychotherapy can often help to sort these terrible contributors out and clarify the true source of dysfunction. Exercises That Cause Back PainExercises that cause back pain is a controversial topic that always creates heated debate among patients and doctors alike.
Diagnosis of Pinched NervesThe diagnosis of pinched nerves is not always a certain science and many compressive neuropathies are misdiagnosed. Overcoming Back SpasmsOvercoming back spasms story, sent in by Cyrus, details a long history of muscular issues and an eventual all-natural solution. Opioids are regularly used by 4.3 million Americans for treatment of chronic cancer and non-cancer pain. Opioid induced androgen deficiency hypogonadism syndrome is also known as OPIAD syndrome.1 In male or female, hypogonadism or OPIAD syndrome causes low testosterone or low female ovarian sex hormone. Long-acting opioid preparation suppresses hypothalamic-pituitary-gonadal axis in male patients and produces a symptomatic state of opioid-induced androgen deficiency (OPIAD).
Hypogonadism is seen in 74% of the men taking long-acting opioids and 34% of the men using short-acting opioids.


Deficiency of gonadotropins like follicle stimulating hormone and luteinizing hormone causes inadequate production of testosterone sex hormones in men. Long acting opioids and prolonged treatment with either short or long acting opioid causes more often hypogonadism leading to erectile dysfunction in men and infertility in female patents. Opioid induced androgen deficiency (OPIAD) is becoming increasingly prevalent among chronic opioid consumers but often goes unrecognized. Options of treatment include testosterone preparations for males and dehydroepiandrosterone (DHEA) supplementation for females. Erectile dysfunction was assessed by questionnaire and NSAID use was determined using pharmacy records and self-reported data. Even when the scientists controlled for age, race and ethnicity, smoking, diabetes, hypertension, high cholesterol, and coronary artery disease among other health problems, a link between NSAID use and erection problems still existed, said Jacobsen.
He says that the drugs have many proven benefits, and that men whose doctors have prescribed NSAIDs for other reasons shouldn’t cut them short. Low testosterone is also known as male hypogonadism, which causes male erectile dysfunction.
Opioid analgesia impairs gonadal function in men leading to erectile deficiency and in women causes menstrual abnormalities and infertility.
Testosterone level was significantly lower in patients taking higher dosage of longer acting opioids.



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