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Delecluse expects that his findings will be a major step toward preventing virus-induced cancers in the future.
Ming-Han Tsai, Ana Raykova, Olaf Klinke, Katharina Bernhardt, Kathrin Gärtner, Carol S.
The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. Could the Epstein-Barr Virus - Autoimmunity Hypothesis Help Explain Chronic Fatigue Syndrome? Simmaron ResearchPathogensCould the Epstein-Barr Virus – Autoimmunity Hypothesis Help Explain Chronic Fatigue Syndrome? Those findings made sense given anecdotal evidence from doctors and study evidence from Dr. About a decade ago Michael Prender proposed being exposed to EBV is a prerequisite for having autoimmune disorder. EBV infections in the body are usually tightly controlled by killer or cytotoxic T-cells (CD8+ T-cells). Pender believes reduced cytotoxic T-cell functioning plays a key role in EBV triggered autoimmunity.
Pender and other researchers believe an inherited defect in cytotoxic T-cells that prevents them from controlling EBV may be behind a lot of autoimmunity.
In what is essentially a numbers game, Pender believes that poorly functioning cytotoxic T-cells allow more EBV infected B-cells to proliferate.
In fact, given the similarity in the killing systems in cytotoxic T-cells and NK cells, it wouldn’t be surprising to find the same dysfunction in both NK cells and CD8+ T-cells.
If that’s true, your cytotoxic T-cells may not be taking out as many EBV infected B-cells as normal. By age sixteen, however, those cytotoxic T-cell levels are a third of what they were at age two. Being exposed to EBV later in life greatly increases the difficulty the body has in fighting it off. It appears that the Western fanaticism with cleanliness is pushing the date most children are exposed to EBV further and further forward. As many as 50% of these children may come down with a symptomatic, infectious mononucleosis-like illness and during that illness as many as half of B-cells in their blood may become infected with EBV  –  producing a huge reservoir of highly active EBV infected B-cells.
Pender ties in other autoimmune factors, many of which are found in Chronic Fatigue Syndrome as well. Autoimmune disorders are have a higher degree of heritability than most disorders – an intriguing factor given that cytotoxic T-cell functioning is largely governed by heredity.
Living further from the equator also increases the risk of autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. Reduced sunlight and vitamin D3 could aggravate  cytotoxic T-cell problems thus imperiling control of EBV.
Cytotoxic T-cells are believed to be hormonally regulated (with increasing estrogen reducing Tc levels) and women tend to have fewer cytotoxic T-cells than men. Pender’s treatment recommendations for EBV triggered autoimmune disorders are enticing given what we know about Chronic Fatigue Syndrome. Michael Pender, has proposedthat exposure  to Epstein-Barr virus, a virus that takes up residence in the B-cells, is required for autoimmunity.
All B-cells produce autoantibodies that would, if the immune system didn’t filter them out, attack the body. EBV prompts B-cells to produce EBV infected B-cells which live longer and produce more B-cells than usual. Pender believes high numbers of autoantibodies produced  by these B-cells overwhelm the immune system causing an autoimmune disorder.
The key problem in autoimmunity Pender believes, then, is large numbers of EBV-infected B-cells. Since cytotoxic T-cells kill EBV-infected B-cells, a poor cytotoxic T-cell response may be the key, and indeed reduced cytotoxic T-cell responses appear to be common  in autoimmune disorders. Because cytotoxic T-cell responses decline over time, someone exposed to EBV as an adolescent typically has a much more difficult time fighting off EBV than a young child does. An allergic reaction that was never treated caused my throat to hurt so that I couldn’t sleep unless I sat up at night.
I was diagnosed with CFS in the 1980s because as the time, chronic EBV was synonymous with CFS.
In NYC AIDS was taken pretty seriously, and btw, AIDS appeared in the same group of gay man that had recently been vaccinated with an experimental Hep B vaccine.
I use a different olive leaf extract for viruses, but Anthony’s suggestion was the one by the American company ( also highly reputable) called Allergy Research and was their standard olive leaf extract and was also used at the strength suggested by the manufacturer for the alternating 6 weeks. This is anecdotal evidence and it took a long course of supplementation and clear the virus BUT it is also very low risk so possibly worth a try. As a person who responds well to antivirals, and one who has a history of mono as a teenager, the EBV reactivation hypothesis resonates with me intuitively. This is the intermolecular binding between viral capsid proteins and receptors on the outer membrane of the host cell. Replication is the actual synthesis of the virus messenger RNA, except for the case of positive sense RNA. Entamoeba histolytica is an anaerobic parasitic protozoan that is part of the genus Entamoeba. Halobacterium salinarum is an extremely halophilic marni Gram-negative obligate aerobic archaeon. Bacteria were first absorbed by a Dutch microscopist, Antonie van Leeuwenhoek back in 1676. All protozoan species are assigned to the kingdom Protista in the Whittaker classification.
The official cause of Chronic Fatigue Syndrome (CFS) is still undecided by doctors and scientists, even though it was first diagnosed and named more than two decades ago.



Poor digestion, unhealthy food choices, and the inability to handle life’s stresses can be considered root causes of CFS, although the causes and symptoms are so intertwined, it can be difficult to get to the bottom of things. It is so important to stay away from junk food – caffeine, alcohol, refined sugars, and other nutrition-stripped foods may aggravate (and will certainly not help) the depressed immune system that goes along with CFS. The blood type diet (Eat Right 4 Your Type by D’Adamo) can give you a guideline on foods that will help or harm your efforts (don’t know your blood type?
Wheat sensitivity, and gluten in particular, seem to be very common among persons with Chronic Fatigue Syndrome. My favorite stress-reducing remedy is Rescue Remedy® from the collection of Bach Flower Essences.
Empowering your immune system is the best possible way of avoiding infection, and is also many times the best treatment. Kidney StonesMost kidney stones are made up of calcium and calcium salts, including oxalates. If you appreciate these shared insights and knowledge, I would most certainly appreciate any contributions you are led to make. Sherri Stockman ND is a medical intuitive, a transformational specialist, an empath, and is also the top Personal Wellness Consultant online. She uses her knowledge and experience as a practicing Naturopath and her skills as an Intuitive and an Energy Healer to help people like you heal themselves.
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In most cases, an infection causes no harm, but sometimes the outcome is a serious disease. Now scientists from a team headed by Henri-Jacques Delecluse at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have found out that Epstein-Barr viruses come in various strains that differ in terms of their aggressiveness. In Africa, simultaneous infection with the parasite that causes malaria may induce Burkitt’s lymphoma. The DKFZ scientists discovered that the two virus strains had important differences: The virus from the Chinese cancer patient is particularly efficient in infecting epithelial cells of the mucous membranes, while that of the American patient suffering from infectious mononucleosis infects only B cells of the immune system. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer.
Also referred to as Human Herpes Virus 4 (HHV-4), the EBV has been identified as one of the commonest viruses among humans and also leads to infectious mononucleosis, the symptoms of which includes fever, sore throat and inflamed lymph glands.
It’s possible, even probable,  that most researchers outside this field including Dr. In doing so he tossed aside the usual EBV mimicry hypothesis; that proteins found in EBV confused the immune system into attacking the body and put forth a much encompassing idea. As we learned in the Rose autoimmune talk, the production of autoantibodies primed to attack the body is a natural outcome of an immune system that must defend the body against microbes containing proteins that are very similar to those found in humans. Every time the B-cell replicates EBV hijacks its reproductive machinery to produce more EBV virions.
One way EBV does this is by tricking the immune system to believe an pathogen is present, thereby causing it to ramp up B-cell production.
Because EBV induces these B-cells to proliferate at a higher than normal rate the outcome of a less controlled EBV infection is simply more and more B-cells. In the developing world most children are exposed to EBV by age three, and almost 100% are exposed by age ten, but some studies suggest about half the children in the developed world  have not been exposed to EBV by the time they’re ten. It turns out that cytotoxic T cells contain more vitamin D3 receptors than any other immune cell.
Their longer lifespan and higher productivity means EBV infected B-cells also produce more autoantibodies than normal B-cells. Even if we are looking at the most carefully screened and thoroughly tested patients asked to be prototypes from the Incline Village epidemic, not all were EBV+. However my personal feeling is that it has less to do with any particular virus and and more to do with a level of infection. A way that you could use a lot of these ideas is that you come up with an adequate case definition. I feel like concentrating on one virus like this is the research equivalent of treading water. I have high positive IGG EBV VCA and EBV Nuclear AG (EBNA) AB IGG, but negative on every other EBV test.
But how many people had to die before that disease was taken seriously and the HIV virus was identified?
Discovering which comes first, the cart, the horse, the chicken or the egg and whether any (or all) of them is irrelevant, is a difficult conundrum. I have just been to a nutrition seminar by British nutritionist Antony Hayes ofBritish company Nutri-Link. The details of the binding process will determine the host species and cell types that are receptive to viral infection.
An example would be that in the case of HIV, this process takes place once the virus has escaped out of the host cell.
Some people are able to carry this chronic fatigue virus and feel fine, while others can be almost completely debilitated. So to treat Chronic Fatigue will usually involve a number of lifestyle changes in addition to any nutritional supplements required.
Of course, the long term answer to stress has to be a change in your lifestyle, but the Flower Remedies are extremely helpful in the meantime. It uses a fiber optic thread which is inserted directly into the vein and the treatment lasts for an hour, so all the blood is treated. EBV may lead to infectious mononucleosis (Pfeiffera€™s disease), which is common in Germany; in other parts of the world it even causes cancer.


These findings are extremely important both in finding strategies to fight the diseases caused by EBV and for developing vaccines against infections with the virus.
The age of an initial infection is believed to play a role in infectious mononucleosis, and in China, substances in people’s diet seemed to promote nasopharyngeal cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. It is also related to some particular cancer types, such as Burkitt’s lymphoma, Hodgkin’s lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas linked with HIV. The immune system has ways to deal with these autoantibodies and in most cases it succeeds. If it’s on high alert the risk of a catastrophic mistake  increases greatly, and here is where Pender and his hypothesis comes in. It turns out that infants have very high levels of cytotoxic T-cells that allow them to stop the virus in its tracks.
This would simply require determining which adolescents have not been exposed to EBV and vaccinating them.
A trigger of some description, Virus, Bacteria or any other sets the immune system off and it refuses to calm down. His first most successful treatment is Famvir 500mg twice a day with Celebrex 200mg twice a day. He had a patient with strange unexplained symptoms,with autonimmune issues which did not, however, fit the usual CFS pattern. Keep this up for six weeks and then switch to the Olive Leaf extract for 6 weeks and keep it up this six weeks alternately for about for a year. This mechanism is believed to have evolved to discriminate in favor of those viruses that only infect cells in which they are capable of replication.
It then exposes the viral genome to the interior of the host cell’s chemical factory. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Apparently, this virus infection is linked with a higher risk of some of the autoimmune diseases, particularly dermatomyositis, rheumatoid arthritis, systemic lupus erythematosus, Sjogren’s syndrome, and multiple sclerosis. Somehow B-cells have managed to thrive survive in the  very cells that are designed to attack them.
Given that Jason expects perhaps as many as 10 percent of college freshman to come down with some form of infectious mononucleosis this would seem to be a really good idea.
Lyme disease is so similar to CFS, post polio syndrome all of these things are similar with different initial enemies triggering the response which is autoimmune. You start by identifying true cases and matched controls, and you can go through and create hypotheses. Lerner commonly finds EBV reactivation in his patients (other researchers do not agree on what constitutes reactivation).
As in a forest fire, the triggering illness is simply the spark that set the forest ablaze – at that point the blazing inferno is the problem not the spark which has long since dissipated. Please note that certain plant viruses can pass from cell to cell through plasmodesmata, or pore structures.  Bacteria have significantly strong cell walls. It only becomes active come to life at a later time when the activated virus subsequently lyses. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. Lets not forget that Glandular Fever, cold sores in embarrassing places or on the faces of schoolkids and certain childhood illnesses are all viruses in the Herpes family.
How can all of these viruses be “Past Infection” when you were never diagnosed with an Active infection in the past? In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. This showed some occult virus activation so he went with the idea she might have chronic EP infection. Attachment to the outer host cell membrane may cause the viral-envelope protein to undergo changes that result in the fusion of virus and host cell membranes. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients.
He treated with 6 weeks of Olive Leaf extract ( form American supply Allergy Research) alternated with 6 weeks of orangano oil (also from Allergy research I think) . DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Württemberg.
Peterson to be prototypes for the illness they were studying) would not be at the top of the list of those who qualify. You had this collection of individuals who had Kaposi’s sarcoma and pneumocystis, but you had no idea what caused it.
After 18 months she had no side effects from the treatment and total freedom from symptoms.
They sat down and had this clear case definition that you can try to tease apart from there. It’s surprising to me, and I guess it’s because it’s such a nebulous thing, that no one’s ever sat down and done this.



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