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Epidermolysis Bullosa (EB) is a genetic skin disorder characterized by blister formation from mechanical trauma. It has been estimated that 1 out of every 20,000 live births in the United States are affected with some type of EB. This entry was posted in Disease, Skin and tagged butterfly children, Epidermolysis bullosa, photo, photograph.
For over 2000 years artists have illustrated the intricate structure of the human body, creating images to elucidate medical procedures and record the pathologies of the body. There are 4 main types: EB Simplex, Junctional EB, Dystophic EB, and Kindler Syndrome, with additional sub-types identified with in each type of EB. Simply swallowing food or wearing clothing with seams can result in agonizing wounds in the more severe forms of EB.



The current standard of care is supportive which includes daily wound care, specialized atraumatic dressings and pain management. The disorder occurs in every racial and ethnic group throughout the world and affects both sexes equally. Minor mechanical friction or trauma will separate the layers of the skin and form blisters.
In the most severe forms any epithelial tissue may form a blister secondary to minor trauma. It is caused by a mutation in the integrin ?6?4 cell adhesion molecule on either the alpha or beta subunit. People with this condition have an increased risk of cancers of the skin, and many will eventually be diagnosed with it as a complication of the chronic damage done to the skin.


There is a spectrum of severity, and within each type, one may be either mildly or severely affected.
EB ranges from being a minor inconvenience requiring modification of some daily activities to being completely disabling and, in some cases, fatal.



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