Unified parkinson disease rating scale updrs part iii,stage 3 lung cancer survival statistics,best healthy food to eat when hungover - New On 2016

admin | Category: What Cause Ed | 10.04.2014
Key words: 6-minute walk distance, ambulatory function, disease severity, endurance, motor function, Parkinson disease, self-selected walking speed, UPDRS, VO2 peak, walking.
Abbreviations: 6MW = 6-minute walk distance, H-Y = Hoehn and Yahr scale, PD = Parkinson disease, SE = standard error, SSWS = self-selected walking speed, UPDRS = Unified Parkinson’s Disease Rating Scale, VA = Department of Veterans Affairs, VO2 peak = peak aerobic capacity.
The Unified Parkinson’s Disease Rating Scale (UPDRS) is the most widely applied rating instrument for Parkinson disease (PD) [1–2].
The UPDRS includes an examination of extrapyramidal motor function and has been shown to predict physical performance measures with a strong balance component, such as Berg Balance and the functional reach tests [3–4]. Recruits for this cross-sectional study came from the University of Maryland Parkinson’s Disease Center and the Baltimore Department of Veterans Affairs (VA) Medical Center. All tests of VO2 peak and ambulatory function were conducted on separate days to avoid the confounding effects of fatigue. The UPDRS scale was scored by a single neurologist to avoid the confounding effects of interrater variability. Treadmill testing was always conducted during the early afternoon hours when subjects were “on” soon after taking medication. Both the treadmill testing (VO2 peak) and over-ground ambulatory function testing (SSWS and 6MW) protocols have been previously described for this study population in articles by Katzel et al.
Separate multiple regressions were used to evaluate UPDRS as a predictor of each of the three performance measures (VO2 peak, SSWS, and 6MW). SD = standard deviation, UPDRS = Unified Parkinson’s Disease Rating Scale, VO2 peak = peak aerobic capacity. Relationship between Unified Parkinson’s Disease Rating Scale (UPDRS) (Total and Motor scales) and peak aerobic capacity (VO2 peak) with and without (bold) Hoehn-Yahr scale entered in model. It was originally published in 1967 in the journal Neurology by Melvin Yahr and Margaret Hoehn and included stages 1 through 5.
Much has been written about sleep issues associated with Parkinson’s disease (PD), including excessive daytime sleepiness (EDS). The term, EDS, refers to the inappropriate propensity for, as well as the actual inappropriate occurrence of, sleep during normal waking hours. References1.Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N, Movement Disorder Society UPDRS Revision Task Force.
Protocolo de Investigacion Cientifica Se investiga si una dieta baja en aluminio y fluoruro puede revertir los sintomas de la enfermedad de Parkinson?s. Una joven paciente con Parkinson Juvenil Paciente con Parkinson Juvenil Su historia en SlideShare Guia Parkinson Juvenil.
The Movement Disorder Society-UPDRS (MDS-UPDRS) was published in 2008, showing satisfactory clinimetric results and has been proposed as the official benchmark scale for Parkinson’s disease.
References1.Chaudhuri KR, Healy D, Schapira AHV (2006) The non-motor symptoms of Parkinson’s disease. CrossRef23.Eisen M, Ware JE Jr, Donald CA, Brook RH (1979) Measuring components of children’s health status. 25.Hobart J, Lamping D, Fitzpatrick R, Riazi A, Thompson A (2001) The Multiple Sclerosis Impact Scale (MSIS-29). JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Our objective was to assess the utility of UPDRS for predicting peak aerobic capacity (VO2 peak) and ambulatory function. Further, previous studies have shown that the UPDRS associates with daily function [3–5] and is sensitive to change over time [1] and across rehabilitation interventions [5–6].
All had volunteered to participate in a randomized exercise intervention trial designed specifically for PD patients. The evaluator is a board-certified neurologist and specialist in PD who is certified in the administration of the UPDRS.
Exercise tests were terminated according to American College of Sports Medicine guidelines [10].
The Hoehn and Yahr scale is a commonly used system for describing how the symptoms of Parkinson's disease progress.
This chapter enumerates these issues related to the disease itself, whether directly or indirectly. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.
La enfermedad de Parkinson es una enfermedad degenerativa que tiene una ocurrencia en Mexico de 50 casos por cada 100,000 habitantes de la poblacion en general. Objetivos del estudio Por estudio comparativo de grupos de cohortes de todas las edades con la enfermedad de Parkinson, usando como variable independiente una dieta baja en aluminio y fluoruro (Trabajo de investigacion aun no publicado ?Dieta sin aluminio? escrito por la Dra Andrea Langhorne Shriver-se anexa al fin de este trabajo) que se le dara a la mitad de los pacientes y la otra mitad comeran su dieta normal. Antecedentes Cientificos En 1817 el doctor ingles, James Parkinson publico un trabajo en lo cual describio 6 pacientes afectados por una postura flexionada, movimientos despacios, tendencia de caminar con pasos chiquitos y rapidos y temblor de una o mas extremidades. Antecedentes Cientificos La enfermedad de Parkinson es el primer ejemplo de una enfermedad causada por la falta de un solo neurotransmisor. Antecedentes Cientificos Parkinson?s por uso de MPTP- Un grupo de adictos a drogas contrataron Parkinson?s por accidente cuando se injectaron con el compuesto MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine). Antecedentes Cientificos Parkinson?s por uso de MPTP- continuacion Este transportador de dopamina recoge el neurotoxico MPP plus (quimicamente similar a la dopamina) y lo lleva a la celula dopaminergica (celula que libera dopamina). Antecedentes Cientificos Diferentes partes de una celula humana- de izquierda a derecha: 1.
Antecedentes Cientificos RESPIRACION CELULAR La produccion de ATP en el mitochondrio: Protones son bombeados afuera del mitocondrio por complejos I, III, y IV de la cadena de electrones (complejo II es mobil). Antecedentes Cientificos AlF3 (una molecula de aluminio mas 3 de fluoruro), tambien se acumula en el mitocondrio donde inhibe el complejo V (cinco), tambien llamada: ATPase o F1F0- ATPase de la respiracion celular. Antecedentes Cientificos El complejo V de la cadena de respiracion celular, tambien conocido como ATPase-F1F0. Antecedentes Cientificos La parte F1 de ATPase-F1F0 es inactivado por el complejo AlF3 (una molecula de aluminio mas 3 moleculas de fluoruro). Antecedentes Cientificos Aluminio es absorbido por el intestino delgado y entra la sangre(12). Antecedendetes Cientificos En los 1960 aparecio esta sal en Mexico y hoy en dia esta en casi todo hogar. Antecedentes Cientificos Cocinando con ollas de alumino y los cubiertos para que no se pegue la comida tienen la posibilidad de contaminar la comida(17). Antecedentes Cientificos Las cajitas forradas con aluminio tienen la posibilidad de contaminar su contenido, especialmente por su larga duracion de caducidad.
Planteamiento del problema ?Si la enfermedad de Parkinson?s puede ser causada por MTPT intravenosa, la cual inhibe el complejo I de la cadena de respiracion celular del mitocondrio de la celula que produce dopamina, pudiera causar la misma enfermedad, la ingesta de aluminio y fluoruro en sal, lo cual inhibe el complejo V (cinco) de la cadena de respiracion celular del mitocondrio de la misma celula? Definicion operacional de las variables Variable independiente (una dieta baja en aluminio y fluoruro) va a prevenir la muerte de la celula dopaminergica del paciente con Parkinson?s. Indicacion de los variables Variable independiete (dieta sin aluminio ni fluoruro) basicamente consiste en sustituir la sal que contiene aluminio y fluoruro con sal pura de mar. Indicacion de los variables Variable independiete : medicamentos usados en el tratamiento de Parkinson Las estrategias usadas en el tratamiento de Parkinson tiene como meta incrementar la actividad dopaminergica y disminuir la actividad cerebral colinergica muscarinica, porque en esta enfermedad hay una disminucion de dopamina y un aumento en la actividad colinergica por la misma falta de dopamina que naturalmente regula a la actividad colinergica del cerebro.
The present study, based on the official MDS-UPDRS Spanish version, performed the first independent testing of the scale and adds information on its clinimetric properties. In: Fahn S, Marsden CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson’s disease, vol 2.


McGraw-Hill, New York7.Gibb WRG, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease.
In: Grandas F, Obeso JA, Tolosa E (eds) Tratado sobre la Enfermedad de Parkinson, 3? Edicion. In: Jenkinson C, Fitzpatrick R, Jenkinson D (eds) Health status measurement in neurological disorders. Participants (n = 70) underwent evaluation for UPDRS (Total and Motor ratings), VO2 peak, 6-minute walk distance (6MW), and 30-foot self-selected walking speed (SSWS).
The UPDRS does not assess general cardiovascular fitness and provides only limited information on functional performance relevant to daily activities, although this information would facilitate clinical decision-making. However, uncertainty remains regarding the extent to which UPDRS predicts important aspects of function associated with ambulatory function, considering that prior investigations have failed to observe associations between UPDRS and 6-minute walk distance (6MW) [7] or between UPRDS and submaximal oxygen consumption during treadmill walking [8]. The treadmill VO2 peak test was done 1 wk after assessment of ambulatory function (self-selected walking speed [SSWS] and 6MW).
Gait belts and other safety precautions protected against falls resulting from loss of balance. Participants were predominantly Caucasian (90%) and male (71%) and had a mean age of 65 yr (Table 1). This rating system has been largely supplanted by the Unified Parkinson's Disease Rating Scale, which assesses limitation of daily activities and non-motor symptoms in more detail. This program allows participants to learn about the use of this scale, see examples of a rater administering the test to patients, and to view examples of the rating items for the Motor Examination (Part III). Since the recognition of EDS years ago there have been a plethora of articles, research, and observations on sleep in patients with PD and sleep issues have been incorporated into the rubric of what constitutes PD. 1950?s Avid Carlson nos ensena que 80% de la dopamina cerebral se encuentra en la Basal Ganglia.
Medicamentos usados en el tratamiento de Parkinson disminuyen los sintomas de Parkinson pero tienen efectos secundarios y un limite por cuanto tiempo son efectivos.
Por una ley mexicana se agrega fluoruro a la sal (15) y por eso se propone usar sal de mar del mediterraneo; marca Roland(18). The cross-culturally adapted MDS-UPDRS Spanish version showed a comparative fit index ?0.90 for each part (I–IV) relative to the English-language version and was accepted as the Official MDS-UPDRS Spanish version. Wiley, Chichester, pp 45–7127.Wyrwich KW, Bullinger M, Aaronson N, Hays RD, Patrick DL, Symonds T, The Clinical Significance Consensus Meeting Group (2005) Estimating clinically significant differences in quality of life outcomes.
Using regression, we determined the extent to which the Total and Motor UPDRS scores predicted each functional capacity measure after adjusting for age and sex. Therefore, there is value in determining the predictive power of the UPDRS for more time-consuming and resource-intensive measures such as peak aerobic capacity (VO2 peak) and ambulatory function. Importantly, no studies have evaluated whether the UPDRS predicts VO2 peak, a gold standard objective physical performance measure of cardiovascular fitness.
There were no falls during the treadmill VO2 peak tests or assessments of ambulatory function. The models were then rerun after adding a simpler measure of disease progression (Hoehn and Yahr scale [H-Y]) to determine whether the predictive strength of the UPDRS remained. The mean H-Y score of 2.2 was indicative of a mild to moderately impaired population of PD participants. Neither H-Y alone nor H-Y combined with the UPDRS measures was a significant predictor of VO2 peak.
Parkinson se caracteriza por tremor, movimientos despacios, rigidez, falta de expresion facial, depresion y demencia.
Al fin del estudio se compararan los sintomas de los dos grupos usando las siguientes escalas de medicion de la Enfermedad de Parkinson: 1) Estadios de Hoehn y Yahr, 2) Unified Parkinson Disease Rating Scale (UPDRS) y 3) Actividades de la Vida Diaria de Schwab y England (4). Hay leyes que permiten el uso de aluminio en la comida.(16) Cianuro como saben es un veneno para el ser humano. Variable dependiente (sintomas de Parkinson?s) los sintomas de Parkinson deben de mejorar al reducir la muerte de celulas productoras de dopamina. Porque la sal de mar no contiene bastante yodo, se agrega pescado a la dieta, una o dos veces por semana (una fuente natural de yodo).
Como hemos dicho antes el MTPT un producto encontrado en la ilicita atentado de sintesis de la meperidina, mata a la celula productora de dopamina en el cerebro. Data from this scale, applied with other assessments to Spanish-speaking Parkinson’s disease patients in five countries, were analyzed for an independent and complementary clinimetric evaluation. We also tested whether adding the Hoehn and Yahr scale (H-Y) to the model changed predictive power of the UPDRS.
Hence, the current study sought to enhance understanding about whether UPDRS predicts VO2 peak and ambulatory function by examining the relationship of Total and Motor UPDRS with VO2 peak, 6MW, and floor walking speed. Subjects were instructed to use as little handrail support as possible during the treadmill tests.
The means for SSWS, 6MW, and VO2 peak were also consistent with mild to moderate disability. More telling perhaps, the revised Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) includes questions regarding nocturnal and daytime sleep. 0.51Angstrom, bastante pequeno para facilmente entrar por los poros de la membrana nuclear. El cuerpo no puede distinguir entre aluminio y hierro y mete aluminio a la hemoglobina de celulas rojas causando anemia(13). Catechol-O-Methytransferase (COMT) inhibidores a veces mejoran la respuesta del paciente hacia Levodopa. Adjusted for age and sex, both the Total UPDRS and Motor UPDRS subscale failed to predict VO2 peak. Based on limited prior work, we hypothesized that UPDRS would fall short of predicting VO2 peak and ambulatory function, both of which have an endurance requirement.
Therefore, addition of H-Y to the model answers an important question related to whether UPDRS adds anything to the functional information obtained from the more routine H-Y scale.
Se reduce la cantidad de carne y productos lacteos porque estos animales consumen agua municipal que contiene aluminio y fluoruro(19, 20) y acumulan el mismo(12). Toxicidad de Levodopa: casi todas las sintomas adversas se relacionan con que tan alta es la dosis. Aplicandolo a Parkinsons, su interferencia con ATPase-F1F0 de la respiracion celular del mitocondrio(11) de las celulas productoras de dopamina infiere que quitandolo de la dieta debe de disminuir los sintomas de Parkinson. After adding H-Y to the model, Total UPDRS was no longer an independent predictor of 6MW but remained a predictor of SSWS. We conclude that Total and Motor UPDRS rating scales do not predict VO2 peak, but that a weak relationship exists between Total UPDRS and measures of ambulatory function. The intraclass correlation coefficient was higher than 0.85 for the total score of each part. Efectos de comportamiento: anciedad, agitacion, confusion, deluciones, alucinaciones y depresion. Correlation of the MDS-UPDRS parts with other measures for related constructs was high (?0.60) and the standard error of measurement lower than one-third baseline standard deviation for all subscales. Results confirm those of the original study and add information on scale reliability, construct validity, and precision. Hallucination, dreaming and frequent dozing in Parkinson’s disease: impact of right hemisphere neural networks.


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