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15.10.2015
The identification of the mechanism that causes white fat cells to become brown fat cells could lead to new treatments for obesity and type-2 diabetes (Photo: Shutterstock). Earlier this year, a team from UC San Francisco reported on the discovery that a class of commonly prescribed type-2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of energy-storing white fat cells into energy-burning brown fat cells. While it was known that TZDs have the ability to change white fat cells to brown fat cells by activating a cell receptor called peroxisome proliferator-activated receptor–gamma (ppar-gamma), the exact mechanism behind this transformation was unclear. Having previously shown that increasing the activity of a group of enzymes called sirtuins (or Sir2) in mice resulted in increased metabolic activity, the CUMC team has now shown that this boost in metabolism is a result of promoting the browning of white fat. Knowing that sirtuins work by severing the chemical bonds between acetyl groups and proteins in a process known as deacetylation, the researchers wanted to uncover whether sirtuins remove acetyl groups from ppar-gamma and if this deacetylation of ppar-gamma is crucial to the browning of white fat.
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Recently, however, a blend of two herbal ingredients—Sphaeranthus indicus extract (from a plant widely used in Ayurvedic medicine) and Garcinia mangostana (from the rinds of mangosteen fruits)—has actually been shown to help people shed both pounds and inches, according to research at both the University of California, Davis and a hospital in Vijayawada, India. Top 7 Diseases That Can Take Your Life New Drugs Not the Only Answer to Ebola Epidemic Obesity Hypoventilation Syndrome Bacterial skin infections – Causes, Types and Treatments Healthy Drinks to Stay Fit and Healthy Pfizer profit down 15% from generic competition Childhood obesity prevention programs Is there a Generic Viagra? Now researchers at Columbia University Medical Center (CUMC) have identified the mechanism that causes this change to take place, potentially leading to new treatments for obesity and type-2 diabetes.


Because TZDs have numerous adverse side effects, including liver toxicity, bone loss and, surprisingly enough, weight gain, the CUMC researchers, led by Domenico Accili, MD, professor of Medicine and the Russell Berrie Foundation Professor at CUMC, were attempting to find a safer way to change white fat to brown fat. They confirmed this is the case by creating a mutant gene of ppar-gamma that, in effect, mimicked the actions of sirtuins and promoted the development of brown fat-like qualities in white fat cells in both mice and human fat tissue. Most popular weight-management programs are ineffective at helping people lose weight and maintain their lower body mass, a new study reveals. Hemoglobin is the oxygen carrying pigment in the blood which is also responsible for its red color. The study authors concluded that the blend, along with lifestyle changes, may change pathways involved in metabolizing sugar and fat. The fact is that anemia is a manifestation or complication of some other disease and not a diagnosis in itself. For instance, the people who took the herbal combo showed an increase in levels of adiponectin, a protein that breaks down fat.
Various infections, inflammations and malignancies show anemia as one of its complications. And they weren’t just slimmer—they were healthier too: Their total cholesterol and triglycerides improved, as did their fasting blood-glucose levels. Anemia is also associated with conditions such as hemorrhage, ulcers, menstrual problems or cancers. It can also be accompanied by headache and temporary blurring of vision.One of most common complains of children is decreased concentration.
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Causes of Anemia There are various causes of Anemia that can range from family history to infections. Men are not that easily affected though they too have a tendency to develop it in the form of a disorder.
Some of the most common forms of anemia are thalassemia, hemoglobinopathies, Rh null disease, enzyme abnormalities of the glycolytic pathways and hereditary xerocytosis.Nutritional- people who do not have a balanced diet are more prone to such diseases as they could be suffering from deficiency in their daily intake.
The most common forms of nutritional anemia are iron deficiency, Vitamin B-12 deficiency, folate deficiency and malnutrition due to starvation.Hemorrhage- this is the term that is used to describe the loss of blood in from the body due to some form of cuts or injury. Hemorrhage is one of the most common causes of anemia in men.Immunologic- this is one of the rare forms of anemia in which the body tends produce antibody mediated abnormalities.
These can affect production and circulation of red blood cells in the body, ultimately leading to anemia.Physical trauma- certain physical traumas and weather conditions can lead to this form of injury due to which the body my lose blood and become anemic.
Among these, the most common are burns, frostbite and prosthetic calves and surfaces.Medications- consuming certain medications for a long time can also lead to anemia.
Some of the most common forms of anemia that occurs as a reaction to drugs is aplastic anemia and megaloblastic anemia.Chronic diseases and cancer- certain chronic diseases can result in loss of blood or hamper the rate at which red blood cells are produced. The most common among them are renal diseases, hepatic diseases, neoplasia and collagen vascular diseases.Infections- microbial infections can also destroy red blood cells, thus causing anemia. Hepatitis, gram-negative sepsis, malaria, toxoplasmosis, clostridia and cytomegalovirus are some of the most common infections.Conditions- certain medical conditions such as thrombotic thrombocytopenic purpura and hemolytic uremic syndrome can also cause anemia.



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